Abstract
In animal toxicity studies it is standard practice to monitor food and water consumption. Changes in these parameters are not only sensitive indicators of general toxicity but may also uncover interesting pharmacological qualities of the test drugs. For example, in chronic toxicity studies on chlordiazepoxide an appetite stimulating effect was discovered which proved to be characteristic of a particular type of antianxiety agents (Zbinden and Randall, 1961). Chlordiazepoxide also stimulated drinking, an effect known to occur with compounds of various pharmacological classes, e. g. levorphanol, hypnotic barbiturates (Schmidt, 1964), antithyroid drugs (Fregly and Taylor, 1964), atropine (Soulairac, 1969), isoprenaline (Lehr, Mallow, and Krukowski, 1967) and serotonin (Goldman, Krukowski, and Lehr, 1968). In this paper increased water consumption by rats treated with isoniazid (INH) is reported. It was accidentally observed during a subacute toxicity study and differed from the effect of the above named drugs in that drinking was not stimulated until 24 hours after withdrawal.
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© 1975 Springer-Verlag Berlin Heidelberg
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Alder, S., Zbinden, G. (1975). Increased Drinking in Rats after Isoniazid Withdrawal. In: Peters, G., Fitzsimons, J.T., Peters-Haefeli, L. (eds) Control Mechanisms of Drinking. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61907-6_28
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DOI: https://doi.org/10.1007/978-3-642-61907-6_28
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