Abstract
Partial constriction of one renal artery of the rat without touching the contralateral kidney induces sodium retention for a period of two to three weeks (Möhring, Näumann, Möhring, Philippi, and Gross, 1971). Subsequently, sodium balance is re-established. However, in those animals in which blood pressure exceeds a critical level, salt and water loss occur (Gross, Dauda, Kazda, Kyncl, Möhring, and Orth, 1972; Möhring et al. 1971); the activity of the renin-angiotensin system is further elevated, plasma aldosterone production is markedly stimulated, and malignant nephrosclerosis of the contralateral kidney may be found (Dauda, Möhring, Hofbauer, Homsy, Miksche, Orth, and Gross, 1973; Möhring et al. 1971; Möhring, Dauda, Haack, Hofbauer, Homsy, Näuman, Orth, and Gross, 1972; Vecsei and Monter, 1973).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
BARRACLOUGH, M. A.: Sodium an water depletion with acute malignant hypertension. Am. J. Med. 40, 265–272 (1966).
BROWN, J. J., CURTIS, J. R., LEVER, A. F., ROBERTSON, J. I. S., DE WARDENER, H. E., WING, A. J.: Plasma renin concentration and the control of blood pressure in patients on maintenance haemodialysis. Nephron 6, 329–349 (1969).
BRUNNER, H. R., LARAGH, J. H., BAER, L., NEWTON, M. A., GOODWIN, F. T., KRAKOFF, L. R., BARD, R. H., BüHLER, F. R.: Essential hypertension: renin, aldosterone, heart attack and stroke. New Engl. J. Med. 286, 441–449 (1972).
DAUDA, G., MÆHRING, J., HOFBAUER, K. G., HOMSY, E., MIKSCHE, U., ORTH, H., GROSS, F.: The vicious circle in acute malignant hypertension of rats. Clin. Sci. 45, 251s-255s (1973).
Dietz, R., Mast, G. J., Gless, K. H., Vecsei, P., Möhring, J., Oster, P., Hackenthal, E., Gross, E.: Aldosterone and corticosterone secretion in rats with benign and malignant hypertension. Advance abstracts, VI Meeting International Study group for Steroid Hormones, Rome 1973.
FITZSIMONS, J.: Thirst. Physiol. Rev. 52, 468–561 (1972).
GROSS, F., DAUDA, G., KAZDA, S., KYNCL, J., MöHRING, J., and ORTH, H.: Increased fluid turnover and the activity of the renin-angiotensin system under various experimental conditions. Circulation Res. 31, 173–181 (1972).
KRAMER, P., OCHWADT, B.: Wasserhaushalt und Elektrolytstoffwechsel bei Ratten mit experimentellem und spontanem Hochdruck. Pflügers Arch, ges. Physiol. 332, 56–72 (1972).
LEENEN, F. H. H., DEJONG, W., DE WIED, D.: Water intake schedules and development of experimental renal hypertension in the rat. Abstract No. 587, Advance abstracts, IV Int. Congr. Endocr., Excerpta Medica Int. Congr. Ser. No. 256, Amsterdam 1972.
MöHRING, J., NAUMANN, H. J., MöHRING, B., PHILIPPI, A., GROSS, F.: Sodium balance and plasma renin activity in renal hypertensive rats. Europ. J. Clin. Invest. 1, 384–389 (1971).
MöHRING, J., DAUDA, G., HAACK, D., HOFBAUER, K.E., HOMSY, E., NAUMANN, H. J., ORTH, H., GROSS, F.: Malignant phase of renal hypertension in rats. Europ. J. Clin. Invest. 2, 297 (1972).
MöHRING, J., MöHRING, B.: Réévaluation of DOCA escape phenomenon. Am. J. Physiol. 223, 1237–1245 (1972a).
——— Evaluation of sodium and potassium balance in rats. J. appl. Physiol. 33, 688–692 (1972b).
Mouw, D., BONJOUR, J.-P., MALVIN, R. L., VANDER, A.: Central action of angiotensin in stimulating ADH release. Am. J. Physiol. 220, 239–242 (1971).
OSTER, P., HACKENTHAL, E., HEPP, R.: Radio-immunoassay of angiotensin II in rat plasma. Experientia 29, 353 (1973).
ROBINSON, M.: Salt in pregnancy. Lancet 274, 178–181 (1958).
STUMPE, K. O., LOWITZ, H. D., OCHWADT, B.: Fluid reabsorption in Henle’s loop and urinary excretion of sodium and water in normal rats and rats with chronic hypertension. J. Clin. Invest. 49, 1200–1212 (1970).
Vecsei, P., Munter, R.: Conversion of precursors to aldosterone in vivo. IV Int. Endocr., Excerpta Medica Int. Congr. Ser. 790–794 (1974).
WANG, L.: Plasma volume, cell volume, total blood volume and Fceils factor in the normal and splenectomized Sherman rat. Am. J. Physiol. 196, 188–192 (1959).
WOLF, G.: Effect of deoxycorticosterone on sodium appetite of intact and adrenalectomized rats. Am. J. Physiol. 208, 1281–1285 (1965).
WOLF, G., HANDAL, P. J.: Aldosterone-induced sodium appetite: dose-response and specificity. Endocrinology 78, 1120–1124 (1966).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1975 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Möhring, J. et al. (1975). Thirst and Salt Appetite in Experimental Renal Hypertension of Rats. In: Peters, G., Fitzsimons, J.T., Peters-Haefeli, L. (eds) Control Mechanisms of Drinking. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61907-6_25
Download citation
DOI: https://doi.org/10.1007/978-3-642-61907-6_25
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-61909-0
Online ISBN: 978-3-642-61907-6
eBook Packages: Springer Book Archive