Abstract
Isoprenaline has been found to be a potent dipsogenic agent in the rat (Zamboni and Siro-Brigiani, 1966; Lehr, Mallow, and Krukowski, 1967). This effect appears to result from β-receptor stimulation, because it is entirely abolished by the β-adrenergic antagonist propranolol (Lehr, Mallow, and Krukowski, 1967; Peskar, Leodolter, and Hertting, 1970). It would appear that, in the rat, the dipsogenic action of isoprenaline is mediated by the renin-angiotensin system because firstly, the response is abolished by bilateral nephrectomy but not by ureteric ligation (Houpt and Epstein, 1971), and secondly, isoprenaline causes an increase in plasma renin level also abolished by propranolol (Meyer, Rauscher, Peskar, and Hertting, 1973).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Assaykeen, T. A., Ganong, W. F.: The sympathetic nervous system and renin secretion. In: Frontiers in Neuroendocrinology (Eds. L. Martini, W. F. Ganong), pp. 67–102. New York: Oxford University Press 1971.
Bunag, R. D., Page, I. H., Mccubbin, J. W.: Neural stimulation of release of renin. Circulation Res. 19, 851–858 (1966).
Fitzsimons, J. T.: Hypovolaemic drinking and renin. J. Physiol. Lond. 186, 130–131P (1966).
Fitzsimons, J. T., Simons, B. J.: The effect on drinking in the rat of intravenous infusion of angiotensin, given alone or in combination with other stimuli of thirst. J. Physiol. Lond. 203, 43–57 (1969).
Gutmann, F. D., Tagawa, H., Haber, E., Barger, G. C.: Renal arterial pressure, renin secretion, and blood pressure control in trained dogs. Am. J. Physiol. 224, 66–72 (1973).
Houpt, K. A., Epstein, A. N.: The complete dependence of beta-adrenergic drinking on the renal dipsogen. Physiol. Behav. 7, 897–902 (1971).
Kozlowski, S., Drzewiecki, K., Zurawski, W.: Zaleznosc reaktywnosci osmotycznej mechanizmu pragnienia od poziomu angiotensyny i aldosteronu we krwi u psów. Acta Physiol. Pol. XXIII (3) (1972).
Kozlowski, S., Szczepanska, E., Drzewiecki, K.: Hormonal influences on osmotic reactivity of the thirst mechanism in dogs. Regional Congress of The International Union of Physiological Sciences. Bra§ov, Rumania, Abstract No 491 (1970).
Lehr, D., Mallow, J., Krukowski, M.: Copious drinking and simultaneous inhibition of urine flow elicited by beta-adrenergic stimulation. J. Pharmac. Exp. Ther. 158, 150–163 (1967).
Meyer, D. K., Rauscher, W., Peskar, B., Hertting, G.: The mechanism of the drinking response to some hypotensive drugs: activation of the renin-angiotensin system by direct or reflex-mediated stimulation of β-receptors. Naunyn-Schmiedeberg’s Arch. Pharmacol. 276, 13–24 (1973).
Peskar, B., Leodolter, S., Hertting, G.: Die Wirkung verschiedener blutdrucksenkender Pharmaca auf Wasseraufnahme und -abgabe bei Ratten. Naunyn-Schmiedeberg’s Arch. Pharmak. 265, 335–346 (1970).
Schaechtelin, G., Baechtold, N., Haefeli, L., Regoli, D., Gaudry-Paredes, A., Peters, G.: A renin inactivating system in rat plasma. Am. J. Physiol. 215, 632–636 (1968).
Seldinger, S. I.: Catheter replacement of the needle in percutaneous arteriography. Acta Radiol. 39, 368–376 (1953).
Zamboni, P., Siro-Brigiani, G.: Effetto delle catecholamine sulla sete e la diuresi nel ratto. Boi. Soc. Ital. Biol. Sper. 42, 1657–1659 (1966).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1975 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Szczepanska-Sadowska, E., Fitzsimons, J.T. (1975). The Effects of Angiotensin II, Renin and Isoprenaline on Drinking in the Dog. In: Peters, G., Fitzsimons, J.T., Peters-Haefeli, L. (eds) Control Mechanisms of Drinking. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61907-6_11
Download citation
DOI: https://doi.org/10.1007/978-3-642-61907-6_11
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-61909-0
Online ISBN: 978-3-642-61907-6
eBook Packages: Springer Book Archive