Advertisement

Noradrenergic and Dopaminergic Influences on Thirst

  • P. E. Setler

Abstract

Two opposing roles have been proposed for central adrenergic neurones in the control of drinking, facilitatory and inhibitory. Although neither role has been established firmly, experimental evidence exists in support of each. Various pharmacological alterations of adrenergic function and different experimental conditions tend to differentially emphasize one or the other role.

Keywords

Water Intake Water Deprivation Preoptic Area Ingestive Behaviour Brain Catecholamine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. ANDEN, N. E., ATACK. C. V., SVENSSON, T. H.: Release of dopamine from central noradrenaline and dopamine nerves induced by a dopamine-β-hydroxylase inhibitor. J. neural Tr. 34, 93–100 (1973).CrossRefGoogle Scholar
  2. BLOOM, F. E., ALGERI, S., GROPPETTI, A., REVUELTA, A., COSTA, E.: Lesions of central norepinephrine terminals with 6-OH-dopamine: biochemistry and fine structure. Science 166, 1284–1286 (1969).PubMedCrossRefGoogle Scholar
  3. CORRODI, H., FUXE, K., HAMBERGER, B., LJUNGDAHL, A.: Studies on central and peripheral noradrenaline neurons using a new dopamine-β-hydroxylase inhibitor. Europ. J. Pharmacol. 12, 145–155 (1970).CrossRefGoogle Scholar
  4. COSTA, E., SPANO, P.F., GROPPETTI, A., ALGERI, S. NEFF, N.: Simultaneous determination of tryptophan, tyrosine, catecholamine and serotonin specific activity in rat brain. Atti. Accad. Med. Lombarda 23, 1100–1104 (1968).Google Scholar
  5. FITZSIMONS, J. T.: Drinking by rats depleted of body fluid without increase in osmotic pressure. J. Physiol. Lond. 159, 297–309 (1961).PubMedGoogle Scholar
  6. ——— The role of a renal thirst factor in drinking induced by extracellular stimuli. J. Physiol. Lond. 201, 349–368 (1969).PubMedGoogle Scholar
  7. FITZSIMONS, J. T., SETLER, P. E.: Catecholaminergic mechanisms in angiotensin-induced drinking. J. Physiol. Lond. 218, 43P–44P (1971).PubMedGoogle Scholar
  8. GIARDINA, A. R., FISHER, A. E.: Effects of atropine on drinking induced by carbachol, angiotensin and isoproterenol. Physiol, Behav. 7, 653–655 (1971).CrossRefGoogle Scholar
  9. GROSSMAN, S. P.: Direct adrenergic and cholinergic stimulation of hypothalamic mechanisms. Am. J. Physiol. 202, 872–882 (1962).PubMedGoogle Scholar
  10. HOUPT, K. A., EPSTEIN, A. N.: The complete dependence of beta-adrenergic drinking on the renal dipsogen. Physiol. Behav. 7, 897–902 (1971).PubMedCrossRefGoogle Scholar
  11. SETLER, P. E.: The role of catecholamines in thirst. In: Neuropsychology of thirst (Eds. A. N. EPSTEIN, H. R. KISSILEFF, E. STELLAR), pp. 279–291. Washington, D.C.: Winston and Sons 1973.Google Scholar
  12. SMITH, G. P.: Introduction to neuropharmacology of thirst. In: Neuropsychology of thirst (Eds. A. N. EPSTEIN, H. R. KISSILEFF, and E. STELLAR), pp. 231–241. Washington, D.C.: V. H. Winston and Sons 1973.Google Scholar
  13. SMITH, G. P., STROHMAYER, A. J., REIS, D. J.: Effect of lateral hypothalamic injections of 6-hydroxydopamine on food and water intake in rats. Nature New Biology 235, 27–29 (1972).PubMedCrossRefGoogle Scholar
  14. SVENSSON, H., WALDECK, B.: On the significance of central noradrenaline for motor acitivity: Experiments with a new dopamine-β-hydroxylase inhibitor. Europ. J. Pharmacol. 7, 278–282 (1969).CrossRefGoogle Scholar
  15. THOENEN, H., TRANZER, J. P.: Chemical sympathectomy by selective destruction of adrenergic nerve endings with 6-hydroxydopamine. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 261, 271–288 (1968).Google Scholar
  16. Ungerstedt, U.: Postsynaptic supersensitivity after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system. Acta physiol. Scand. Suppl. 367, 69–95 (1971a).Google Scholar
  17. ——— Adipsia and aphagia after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system. Acta physiol. Scand. Suppl. 367, 95–122 (1971b).Google Scholar
  18. URETSKY, N. J., IVERSEN, L. L.: Effects of 6-hydroxy-dopamine on catecholamine containing neurons in the rat brain. J. Neurochem. 17, 269–278 (1970).PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1975

Authors and Affiliations

  • P. E. Setler

There are no affiliations available

Personalised recommendations