Abstract
Haemopoietic tissue is widely scattered around the body, residing primarily in the marrow of the skeletal bones. It consists of a large variety of cell types which, in any one site, appear, by the classical techniques of morphology, to be mixed in a totally random manner. There is no obvious geometrical or spatial organisation of these cells. Much is now known about the dynamic behaviour of the cells, their interrelationships and capacities to respond to stress situations. Many reviews on various aspects of the subject have been published and a recent “Clinics in Haematology” (see Lajtha, 1979) represents an excellent, up to date, overview. A number of attempts to model the tissue mathematically has, due to the rapid accumulation of experimental data over the past twenty years, been singularly unsuccessful and though the most recent of them (Wichmann and Loeffler, 1979) has come extremely close to describing most of these data, it, too, has so far been unable to point the way ahead for the experimentalist. In this paper we shall first describe our current understanding of the structure of haemopoiesis, the spatial distribution of the various cell types within the tissue and the regulation of cell proliferation.
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Lord, B.I., Schofield, R. (1980). Some Observations on the Kinetics of Haehomoietic Stem Cells and their Relationship to the Spatial Cellular Organisation of the Tissue. In: Jäger, W., Rost, H., Tautu, P. (eds) Biological Growth and Spread. Lecture Notes in Biomathematics, vol 38. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61850-5_2
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DOI: https://doi.org/10.1007/978-3-642-61850-5_2
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