Genetic Basis of Biological Growth

  • Renato Baserga
Conference paper
Part of the Lecture Notes in Biomathematics book series (LNBM, volume 38)


An increase in the number of cells is one of the fundamental characteristics of biological growth. An increase in cell number depends on cell division and this, in turn, on the ability of the cell to replicate its genetic material. We have therefore studied the Go → S transition in the cell cycle, which is the phase of the cell cycle that determines whether or not a cell will replicate DNA and its chromosomal proteins. We have assumed that the key to our understanding of cell proliferation lies in the identification of genes and gene products that control it. Using cell cycle-specific temperature sensitive mutants and virally-coded proteins from DNA oncogenic viruses, we have tentatively identified five genes that control the Go → S transition of mammalian cells in culture. The experiments demonstrating that ribosomal RNA genes are one set of controlling genes are discussed in detail.


G5554 Cell Nonpermissive Temperature Hybrid Cell Line Biological Growth rRNA Synthesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • Renato Baserga
    • 1
  1. 1.Fels Research Institute and Department of PathologyTemple University Medical SchoolPhiladelphiaUSA

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