Effect of Cyclosporin on the Function of the Proximal Tubule and Loop of Henle in the Rat Kidney

  • H.-U. Gutsche
  • M. Lüneburg
  • K. H. Gnutzmann
  • E. Deltz
  • W. Niedermayer
Conference paper


Renal toxicity is one of the major side effects of immunosuppression with cyclosporine. Apart from an almost regularly observed decrease in glomerular filtration rate (GFR), toxic alterations prevail within the proximal tubule and Henle’s loop. Although detailed descriptions of morphological defect have been published, including vacuolization of the proximal tubular cells, microcalcifications, formations of giant mitochondria together with pathologic vascular and interstitial alterations (Marbet et al. 1980; Shulman et al. 1981; Mihatsch et al. 1981, 1983), little is known about functional characteristics of the nephron segments involved (Thiel et al. 1981, 1982).


Proximal Tubule Kidney Transplant Patient Nephron Segment Tubular Fluid Cyclosporin Treatment 
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Copyright information

© Springer-Verlag Berlin, Heidelberg 1985

Authors and Affiliations

  • H.-U. Gutsche
  • M. Lüneburg
  • K. H. Gnutzmann
  • E. Deltz
  • W. Niedermayer

There are no affiliations available

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