Accelerated But Not Hyperacute Rejection of Liver Allografts in Hypersensitized Rats
The privileged status of liver allografts compared with other organ allografts is illustrated by the spontaneous tolerance of liver allografts in pigs (Calne 1973) and in several combinations of inbred rats (Houssin et al. 1979; Zimmermann et al. 1979). Another remarkable peculiarity of liver transplantation is the absence of hyperacute rejection of liver allografts in man in case of an ABO-incompatible transplantation or when preformed lymphocytotoxic antibodies directed toward the donor are present in the recipient (Starzl et al. 1982). The reason for the relative resistance of the liver to cytotoxic antibodies is still unclear. In order to study further the effect of cytotoxic antibodies on the liver, the fate of donor-specific liver allografts was compared with that of donor-specific heart allografts in hypersensitized rats.
KeywordsLiver Transplantation Liver Allograft Hyperacute Rejection Heart Allograft Cytotoxic Antibody
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