Abstract
The idea of transplanting islets of Langerhans as free grafts has long been attractive because such a procedure should be free of the major complications of whole organ pancreatic transplantation. The introduction of reproducible techniques for isolation of islets in large numbers from the rodent pancreas led to experiments reporting the ease with which islet isografts could be transplanted with reversal of diabetes (Ballinger et al. 1972). Initially it was hoped that islet tissue and other endocrine tissues would be less immunogenic than organs such as the kidney and heart (Lillehei et al. 1970).
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References
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© 1985 Springer-Verlag Berlin, Heidelberg
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Gray, D.W.R., Reece-Smith, H., McShane, P., Morris, P.J. (1985). The Immunogenicity of Pancreatic Islets. In: Thiede, A., Deltz, E., Engemann, R., Hamelmann, H. (eds) Microsurgical Models in Rats for Transplantation Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61657-0_33
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DOI: https://doi.org/10.1007/978-3-642-61657-0_33
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