Investigations of Glucose Tolerance Following Pancreatic Transplantation in Rats with Streptozotocin-Induced Diabetes

  • R. Meister
  • K. Paul
Conference paper


In addition to problems of immune tolerance and the technique of transplantation one must pose the question of how a transplanted pancreas will function under conditions of daily life. In order to investigate this problem we initiated a trial in an animal model. Two questions were of particular interest:
  1. 1.

    Would pancreas transplantation in diabetic recipient animals normalize fasting and stimulated hyperglycemia, the probable cause of vascular damage in diabetics?

  2. 2.

    What are the basal values for insulin, glucagon, and glucose and the secretion kinetics of insulin following various stimulation tests.



Beta Cell Oral Glucose Tolerance Test Diabetic Control Basal Insulin Pancreas Transplantation 
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Copyright information

© Springer-Verlag Berlin, Heidelberg 1985

Authors and Affiliations

  • R. Meister
  • K. Paul

There are no affiliations available

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