Migration of Donor Passenger Cells During Rat Cardiac and Intestinal Allograft Rejection
Many studies have shown that passenger leukocytes in the donor organ play an important role in the sensitization leading to allograft rejection (Lafferty et al. 1975; Snell 1957; Steinmuller 1967; Summerlin 1973; Talmage et a1. 1976). Depletion of passenger leukocytes, prior to transplantation, from endocrine organs by culture techniques (Lacy et a1.1979; Lafferty et a1. 1976; Sollinger et a1. 1977) and treatments of the donor animal or organ with cytotoxic agents (Freeman et al. 1971; Kyger and Salyer 1973; Steinmuller et al. 1971) have resulted in prolonged allograft survival. Guttmann et al. (1973) and Zincke et al. (1978) have demonstrated that cadaver donor pretreatment with methylprednisolone and cyclophosphamide can lead to improved human renal allograft survival. These results were explained by the hypothesis that the number of passenger leukocytes in the graft (Oluwole et al. 1980) was reduced or that the immunogenicity of the donor cells was altered (Van der Linden et al. 1981). Despite these findings, the relationship between the homing patterns of donor passenger leukocytes in the host and the subsequent host immune response is not clearly defined.
KeywordsMesenteric Lymph Node Allograft Rejection Cardiac Allograft Intestinal Transplantation Cardiac Graft
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