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Intracellular Transport of Brush-Border and Lysosomal Enzymes in the Human Enterocyte

  • Chapter
Biomembranes

Abstract

The mechanisms underlying the biosynthesis, intracellular transport, and sorting of proteins destined for extra- and intracellular use have been extensively studied in polarized epithelial cells during the last few years. Much of our understanding about these mechanisms arose from studies on the intracellular pathways taken by newly synthesized viral membrane glycoproteins in cultured epithelial cells (K. Simons and Fuller 1985, N.L. Simons et al. 1985). However, little information is available about the synthesis and transport of endogenous glycoproteins (Danielsen et al. 1984). To study these processes the intestinal epithelial cell (enterocyte) is an attractive model for a number of reasons.

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Author information

Authors and Affiliations

  1. Laboratory for Electron Microscopy, University of Leiden, Rijnsburgerweg 10, 2333 AA, Leiden, The Netherlands

    L. A. Ginsel, J. A. M. Fransen & J. Klumperman

  2. Department of Pharmacology, Biocenter of the University of Basel, CH-4056, Basel, Switzerland

    H. P. Hauri

  3. Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands

    J. Hilgers

  4. Laboratory for Biochemistry, University of Amsterdam, P.O. Box 20151, 1000 HD, Amsterdam, The Netherlands

    R. P. J. Oude Elferink & J. M. Tager

Authors
  1. L. A. Ginsel
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  2. J. A. M. Fransen
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  3. J. Klumperman
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  4. H. P. Hauri
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  5. J. Hilgers
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  6. R. P. J. Oude Elferink
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  7. J. M. Tager
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Editor information

Editors and Affiliations

  1. Department of Cellular Biology Faculty of Medicine, Medical and Pharmaceutical Institute, 3400, Cluj-Napoca, Roumania

    Gheorghe Benga

  2. Laboratory of Biochemistry, University of Amsterdam, 1000 HD, Amsterdam, The Netherlands

    Joseph M. Tager

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© 1988 Springer-Verlag Berlin Heidelberg

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Ginsel, L.A. et al. (1988). Intracellular Transport of Brush-Border and Lysosomal Enzymes in the Human Enterocyte. In: Benga, G., Tager, J.M. (eds) Biomembranes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61374-6_4

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  • DOI: https://doi.org/10.1007/978-3-642-61374-6_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64815-1

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