Cell Populations of the Respiratory System: Interspecies Diversity in Composition, Distribution, and Morphology
A major site for pulmonary injury resulting from exposure to environmental toxicants is the epithelial lining of respiratory airways. This appears to be the case for a wide range of compounds that have been tested for their toxicity to the respiratory system, whether these compounds are administered by inhalation or other systemic means. The extrapolation to humans of inhalation toxicology studies using animal models assumes comparability in the structure and function of the respiratory system of these model species and humans. The underlying assumption is that data obtained in model species can be extrapolated to humans. The primary consideration of this study is that the tracheobronchial epithelium of most mammalian species commonly used as models may not adequately reflect the condition in human conducting airways. This study focuses on the epithelial population lining the tracheobronchial airways (trachea, bronchi, and bronchioles) of the mammalian respiratory system.
KeywordsClara Cell Epithelial Cell Type Submucosal Gland Granular Endoplasmic Reticulum Respiratory Bronchiole
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- 1.Breeze RG, Wheeldon EB (1977) The cells of the pulmonary airways. Am Rev Respir Dis 161:705–777Google Scholar
- 7.Jeffery PK (1977) Structure and function of mucus-secreting cells of cat and goose airway epithelium. Ciba Found Symp 5–19Google Scholar
- 14.Heidsiek JG, Hyde DM, Plopper CG, St George JA (1985) Computerized quantitation of mucosubstances in pulmonary airways of rhesus monkeys. Am Rev Respir Dis 131:A386Google Scholar
- 23.Clara M (1937) Zur histobiologie des bronchial Epithels. Z Mikrosk Anat Forsch 41:321–347Google Scholar
- 24.Hayak H. von (1960) The human lung. Hafner, New YorkGoogle Scholar
- 29.Hyde DM, CG Plopper: Cell and organellar volumes of nonciliated bronchiolar cells of rabbits, cats and monkeys. Anat Ree 208:77AGoogle Scholar
- 32.Marsan C, Cava E, Lougnon J, Roujeau J (1978) Cytochemical and histochemical characterization of epithelial mucins in human bronchi. Acta Cytol (Baltimore) 22:562–565Google Scholar
- 36.Emura M, Mohr U (1975) Morphological studies on the development of tracheal epithelium in the Syrian golden hamster. I. Light microscopy. Versuchstierk 17:14Google Scholar
- 38.McCarthy C, Reid L (1964) Acid mucopolysaccharide in the bronchial tree in mouse and rat (sialomucin and sulphate). Q J Exp Physiol 49:81–84Google Scholar