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Inhalation Toxicology pp 25–40Cite as

Cell Populations of the Respiratory System: Interspecies Diversity in Composition, Distribution, and Morphology

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Part of the book series: ILSI Monographs ((ILSI MONOGRAPHS))

Abstract

A major site for pulmonary injury resulting from exposure to environmental toxicants is the epithelial lining of respiratory airways. This appears to be the case for a wide range of compounds that have been tested for their toxicity to the respiratory system, whether these compounds are administered by inhalation or other systemic means. The extrapolation to humans of inhalation toxicology studies using animal models assumes comparability in the structure and function of the respiratory system of these model species and humans. The underlying assumption is that data obtained in model species can be extrapolated to humans. The primary consideration of this study is that the tracheobronchial epithelium of most mammalian species commonly used as models may not adequately reflect the condition in human conducting airways. This study focuses on the epithelial population lining the tracheobronchial airways (trachea, bronchi, and bronchioles) of the mammalian respiratory system.

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Author information

Authors and Affiliations

  1. California Primate Research Center, University of California, Davis, CA, 95616, USA

    C. G. Plopper, A. Weir, J. St. George, N. Tyler, D. Wilson & D. Hyde

  2. Department of Anatomy, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA

    C. G. Plopper, A. Weir, J. St. George, S. Nishio, D. Cranz, J. Heidsiek & D. Hyde

  3. Department of Veterinary Pathology, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA

    A. Mariassy & D. Wilson

Authors
  1. C. G. Plopper
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  2. A. Weir
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  3. J. St. George
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  4. N. Tyler
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  5. A. Mariassy
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  6. D. Wilson
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  7. S. Nishio
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  8. D. Cranz
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  9. J. Heidsiek
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  10. D. Hyde
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Editor information

Editors and Affiliations

  1. Department of Veterinary Pathology, University of California, Davis, CA, 95616, USA

    Donald L. Dungworth Ph.D. M.R.C.V.S

  2. Bayer AG, Institute for Toxicology, 5600, Wuppertal-Elberfeld, Germany

    Georg Kimmerle Dr.med.

  3. Abbott Laboratories, Abbott Park, IL, 60064, USA

    James Lewkowski M.D.

  4. Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute, P.O. Box 5890, Albuquerque, NM, 87185, USA

    Roger O. McClellan D.V.M.

  5. Fraunhofer Institute of Toxicology and Aerosol Research, Nikolai-Fuchs-Strasse 1, 3000, Hannover 61, Germany

    Werner Stöber Dr.rer.nat.

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© 1988 Springer-Verlag New York Inc.

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Plopper, C.G. et al. (1988). Cell Populations of the Respiratory System: Interspecies Diversity in Composition, Distribution, and Morphology. In: Dungworth, D.L., Kimmerle, G., Lewkowski, J., McClellan, R.O., Stöber, W. (eds) Inhalation Toxicology. ILSI Monographs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61355-5_3

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  • DOI: https://doi.org/10.1007/978-3-642-61355-5_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64806-9

  • Online ISBN: 978-3-642-61355-5

  • eBook Packages: Springer Book Archive

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