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Relevance to Humans of Experimentally Induced Pulmonary Tumors in Rats and Hamsters

  • U. Mohr
  • D. L. Dungworth
Part of the ILSI Monographs book series (ILSI MONOGRAPHS)

Abstract

Extrapolation of data from animal experiments to the human situation is a necessary part of risk assessment. Because both qualitative and quantitative results of carcinogenicity studies vary widely from one animal species to another, it is well recognized that there is a need to use data from several species in extrapolating to possible human effects. Accurate extrapolation requires an understanding of why there are large interspecies differences, and this understanding is beginning to be developed. Two important aspects, namely, interspecies differences in dosimetry of inhaled materials and in epithelial cell biology, are covered elsewhere in this book, and only a few specific examples will be considered here. This article concentrates on lesions observed in lungs of rats and hamsters during in vivo carcinogenicity trials (1) and on comparative information being derived from in vitro studies.

Keywords

Diesel Exhaust Pulmonary Tumor Tracheal Epithelial Cell Hamster Tracheal Epithelium Squamous Cell Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York Inc. 1988

Authors and Affiliations

  • U. Mohr
    • 1
  • D. L. Dungworth
    • 2
  1. 1.Institut für Experimentelle PathologieMedizinische Hochschule HannoverHannover 61Germany
  2. 2.Department of Veterinary PathologyUniversity of CaliforniaDavisUSA

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