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Respiratory Tract Clearance of Particles and Substances Dissociated from Particles

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Inhalation Toxicology

Part of the book series: ILSI Monographs ((ILSI MONOGRAPHS))

Abstract

This report describes the clearance of particles and substances associated with particles deposited in the respiratory tract. It complements the report by Heyder (this volume) on inhaled particle deposition and the reports by Miller (this volume) and Andersen (1) on the deposition of inhaled reactive and nonreactive gases. Most of the information reported here was derived from studies using human subjects. Results of studies using laboratory animals are also described because some measurements cannot be made using human subjects and because it is necessary to compare respiratory tract clearance in people and animals for the purposes of toxicology and human health risk assessment.

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References

  1. Andersen ME (1987) Toxicokinetics of non-reactive gases. Paper delivered at an international symposium on inhalation toxicology, the design and interpretation of inhalation studies and their use in risk assessment, held in Hanover, Federal Republic of Germany, March 1987

    Google Scholar 

  2. Task Group on Lung Dynamics (1966) Deposition and retention models for internal dosimetry of the human respiratory tract. Health Phys 12:173–207

    Google Scholar 

  3. Stradling GN, Ham GJ, Smith H, Cooper J, Breadmore SE (1978) Factors affecting the mobility of plutonium-238 dioxide in the rat. Int J Radiât Biol 34:37–47

    Article  CAS  Google Scholar 

  4. Gearhart JM, Diel JH, McClellan RO (1980) Intrahepatic distribution of plutonium in beagles. Radiat Res 84:343–352

    Article  PubMed  CAS  Google Scholar 

  5. Gore DM, Patrick G (1978) The distribution and clearance of inhaled UO2 particles on the first bifurcation and trachea of rats. Phys Med Biol 23:730–737

    Article  PubMed  CAS  Google Scholar 

  6. Watson MS, Brain SD (1979) Uptake of iron oxide aerosols by mouse airway epithelium. Lab Invest 40:450–459

    PubMed  CAS  Google Scholar 

  7. Benjamin SA, Boecker BB, Cuddihy RG, McClellan RO (1979) Nasal carcinomas in beagles after inhalation of relatively soluble forms of beta-emitting radionuclides. J Nat Cancer Inst 63:133–139

    PubMed  CAS  Google Scholar 

  8. Boecker BB, Hahn FF, Cuddihy RG, Snipes MB, McClellan RO (1986) Is the human nasal cavity at risk from inhaled radionuclides? In: Thompson RC, Mahaffey JA (eds) Life-span radiation effects studies in animals: What can they tell us? pp 564–577 Published by; Office of Scientific and Technical Information; United States Department of Energy

    Google Scholar 

  9. Schlesinger RB, Lippmann M (1978) Selective particle deposition and bronchogenic carcinoma. Environ Res 15:424–431

    Article  PubMed  CAS  Google Scholar 

  10. Lauweryns JM, Baert JH (1977) Alveolar clearance and the role of the pulmonary lymphatics. Am Rev Respir Dis 115:625–683

    PubMed  CAS  Google Scholar 

  11. Harmsen AG, Muggenburg BA, Snipes MB, Bice DE (1985) The role of macrophages in particle translocation from lungs to lymph nodes. Science 230:1277–1280

    Article  PubMed  CAS  Google Scholar 

  12. Vincent JH, Johnston AM, Jones AD, Balton RE, Addison J (1985) Kinetics of deposition and clearance of inhaled mineral dusts during chronic exposure. Br J Ind Med 42:707–715

    PubMed  CAS  Google Scholar 

  13. Morgan A, Holmes A, Davison W (1982) Clearance of sized glass fibres from the rat lung and their solubility in vivo. Ann Occup Hyg 25:317–331

    Article  PubMed  CAS  Google Scholar 

  14. Roggli VL, George MH, Brody AR (1987) Clearance and dimensional changes of crocidolite asbestos fibers isolated from the lungs of rats following short-term exposure. Environ Res 42:94–105

    Article  PubMed  CAS  Google Scholar 

  15. Proctor DF, Andersen I, Lundquist G (1977) Nasal mucociliary function in humans. In: Brain JD, Proctor DF, Reid LM (eds) Respiratory defense mechanisms, part 1. Dekker, New York, pp 427–452

    Google Scholar 

  16. Swift DL, Proctor DF (1977) Access of air to the respiratory tract. In: Brain JD, Proctor DF, Reid LM (eds) Respiratory defense mechanisms, part 1. Dekker, New York, pp. 63–93

    Google Scholar 

  17. Cuddihy RG, Ozog JA (1973) Nasal absorption of CsCl, SrCl2, BaCl2 and CeCl3 in Syrian hamsters. Health Phys 29:219–224

    Article  Google Scholar 

  18. Stather JW, Howden S (1975) The effect of chemical form on the clearance of 239-plutonium from the respiratory system of the rat. Health Phys 28:29–39

    Article  PubMed  CAS  Google Scholar 

  19. Lippmann M (1970) Deposition and clearance of inhaled particles in the human nose. Ann Otol Rhinol Larygnol 76:519–528

    Google Scholar 

  20. Fry FA, Black A (1973) Regional deposition and clearance of particles in the human nose. J Aerosol Sci 4:113–124

    Article  Google Scholar 

  21. Itoh H, Smaldone GC, Swift DL, Wagner HN (1985) Mechanisms of aerosol deposition in a nasal model. J Aerosol Sci 16:529–534

    Article  CAS  Google Scholar 

  22. van Ree JHL, van Dishoeck HAE (1962) Some investigations on nasal ciliary activity. Pract Ororhinolaryngol 24:383–390

    Google Scholar 

  23. Ewert G (1965) On the mucus flow rate in the human nose. Acta Otolaryngol [Suppl] (Stockh) 200:1–62

    Google Scholar 

  24. Quinlan MF, Salmon SD, Swift DL, Wagner HN, Proctor DF (1969) Measurement of mucociliary function in man. Am Rev Respir Dis 99:13–23

    PubMed  CAS  Google Scholar 

  25. Andersen I, Lundqvist GR, Proctor DF (1971) Human nasal mucosal function in a controlled climate. Arch Environ Health 23:408–420

    PubMed  CAS  Google Scholar 

  26. Black A, Evans JC, Hadfield EH, Macbeth RG, Morgan A, Walsh M (1974) Impairment of nasal mucociliary clearance in woodworkers in the furniture industry. Br J Ind Med 31:10–17

    PubMed  CAS  Google Scholar 

  27. Wood RE, Wanner A, Hirsch J, Farrell PM (1975) Tracheal mucociliary transport in patients with cystic fibrosis and its stimulation by terbutaline. Am Rev Respir Dis 111:733–738

    PubMed  CAS  Google Scholar 

  28. Santa Cruz R, Landa J, Hirsch J, Sackner MA (1974) Tracheal mucus velocity in normal man and patients with obstructive lung disease; effects of terbutaline. Am Rev Respir Dis 109:458–463

    PubMed  CAS  Google Scholar 

  29. Goodman RM, Yergin BM, Landa JF, Golinvaux MH, Sachner MA (1978) Relationship of smoking history and pulmonary function tests to tracheal mucus velocity in nonsmokers, young smokers, ex-smokers and patients with chronic bronchitis. Am Rev Respir Dis 117:205–214

    PubMed  CAS  Google Scholar 

  30. Chopra SK, Taplin GV, Elam D, Carson SA, Golde D (1979) Measurement of tracheal mucociliary transport velocity in humans—smokers versus nonsmokers (preliminary findings). Am Rev Respir Dis 119:205

    Google Scholar 

  31. Yeates DB, Aspin M, Levison H, Jones MT, Bryan AC (1975) Mucociliary tracheal transport rates in man. J Appl Physiol 39:487–495

    PubMed  CAS  Google Scholar 

  32. Foster WM, Langenback EG, Bergofsky EH (1982) Lung mucociliary function in man: Interdependence of bronchial and tracheal mucus transport velocities with lung clearance in bronchial asthma and healthy subjects. Ann Occup Hyg 26:227–244

    Article  PubMed  CAS  Google Scholar 

  33. Yeates DB, Aspin M (1978) A mathematical description of the airways of the human lungs. Respir Physiol 32:92–104

    Article  Google Scholar 

  34. Morrow PE, Gibb FR, Gazioglu KM (1967) A study of particulate clearance from the human lungs. Am Rev Respir Dis 96:1209–1221

    PubMed  CAS  Google Scholar 

  35. Yeates DB (1974) The clearance of soluble and particulate aerosols deposited in the human lung. Doctoral thesis, University of Toronto

    Google Scholar 

  36. Bair WJ, Willard H (1963) Plutonium inhalation studies. III. Effect of particle size and total dose on deposition, retention and translocation. Health Phys 9:253–266

    Article  PubMed  CAS  Google Scholar 

  37. Hatch TF, Gross P (1964) Pulmonary deposition and retention of inhaled aerosols. Academic, New York

    Google Scholar 

  38. Lippmann M, Albert R (1969) The effect of particle size on the regional deposition of inhaled aerosols in the human respiratory tract. Am Ind Hyg Assoc J 30:257–275

    PubMed  CAS  Google Scholar 

  39. Albert RE, Lippmann M, Briscoe W (1969) The characteristics of bronchial clearance in humans and the effect of cigarette smoking. Arch Environ Health 18:738–755

    PubMed  CAS  Google Scholar 

  40. Camner P, Philipson K (1978) Human alveolar deposition of 4 um teflon particles. Arch Environ Health 36:181–185

    Google Scholar 

  41. Clarke SW, Parvia D (1980) Lung mucus production and mucociliary clearance: Methods of assessment. Br J Clin Pharmacol 9:537–546

    PubMed  CAS  Google Scholar 

  42. Svartengren M, Widtskiold-Olsson K, Philipson K, Camner P (1981) Retention of particles on the first bifurcation and the trachea of rabbits. Bull Eur Physiopathol Respir 17:87–91

    PubMed  CAS  Google Scholar 

  43. Altshuler B, Nelson N, Kuschner M (1964) Estimation of lung tissue dose from the inhalation of radon and daughters. Health Phys 10:1137–1161

    Article  PubMed  CAS  Google Scholar 

  44. Harley NH, Pasternack BS (1972) Experimental absorption measurements applied to lung dose from radon daughters. Health Phys 23:771–782

    Article  PubMed  CAS  Google Scholar 

  45. Albeit RE, Arnett LC (1955) Clearance of radioactive dust from the human lung. AMA Arch Ind Health 12:99–106

    Google Scholar 

  46. Lee PS, Gerrity TR, Hass FJ, Lourenco RV (1979) A model for tracheobronchial clearance of inhaled particles in man and a comparison with data. IEEE Trans Biomed Eng BME-26, 11:624–630

    Article  Google Scholar 

  47. Stahlhofen W, Gebhart J, Heyder J (1980) Experimental determination of the regional deposition of aerosol particles in the human respiratory tract. Am Ind Hyg Assoc J 41:385–398

    Article  PubMed  CAS  Google Scholar 

  48. Yeh HC, Schum GM (1980) Models of human lung airways and their application to inhaled particle deposition. Bull Math Biol 42:461–480

    PubMed  CAS  Google Scholar 

  49. Bailey MR, Fry FA, James AC (1985) Long-term retention of particles in the human respiratory tract. J Aerosol Sci 16:295–305

    Article  CAS  Google Scholar 

  50. Philipson K, Falk R, Camner P (1985) Long-term lung clearance in humans studied with teflon particles labeled with chromium-51. Exp Lung Res 9:31–42

    Article  PubMed  CAS  Google Scholar 

  51. Bohning DE, Atkins HL, Cohn SH (1982) Long-term particle clearance in man: Normal and impaired. Ann Occup Hyg 26:259–271

    Article  PubMed  CAS  Google Scholar 

  52. Newton D, Fry FA, Taylor BT, Eagle MC, Sharma RC (1978) Interlaboratory comparison of techniques for measuring lung burdens of low-energy photon-emitters. Health Phys 35:751–771

    Article  PubMed  CAS  Google Scholar 

  53. Thomas RG (1972) An interspecies model for retention of inhaled particles. In: Mercer TT, Morrow PE, Stöber W (eds) Assessment of airborne particulates. Thomas, Springfield, pp 405–419

    Google Scholar 

  54. Snipes MB, Boecker BB, McClellan RO (1984) Respiratory tract clearance of inhaled particles in laboratory animals. In: Smith H, Gerber G (eds) Lung modeling for inhalation of radioactive materials, pp 63–71

    Google Scholar 

  55. Cuddihy RG (1978) Deposition and retention of inhaled niobium in beagle dogs. Health Phys 34:167–176

    Article  PubMed  CAS  Google Scholar 

  56. Strom KA, Chan TL, Johnson JT (1985) Pulmonary retention of inhaled submicron particles in rats: Diesel exhaust exposures and lung retention model. Inhaled Particles VI, proceedings of an international symposium organized by the British Occupational Hygiene Society held in Cambridge, England, September 1985

    Google Scholar 

  57. Vostal JJ, Schreck RM, Lee PS, Chan TL, Soderholm SC (1982) Deposition and clearance of diesel particles from the lung. In: Lewtas J (ed) Toxicology of diesel exhaust emissions. Elsevier Biomedical, New York, pp 143–159

    Google Scholar 

  58. Wolff RK, Henderson RF, Snipes MB, Griffith WC, Mauderly JL, Cuddihy RG, McClellan RO (1987) Alterations in particle accumulation and clearance in lungs of rats chronically exposed to diesel exhaust. Fundam Appl Toxicol 9:154–166

    Article  PubMed  CAS  Google Scholar 

  59. Mercer TT (1967) On the role of particle size in the dissolution of lung burdens. Health Phys 13:1211–1221

    Article  PubMed  CAS  Google Scholar 

  60. Cuddihy RG, Boecker BB, Griffith WC (1979) Modeling the deposition and clearance of inhaled radionuclides. In: Proceedings of an international symposium on biological implications of radionuclides released from nuclear industries, 26–30 March 1979, Vienna. International Atomic Energy Agency, pp 77–90

    Google Scholar 

  61. Snipes MB, Boecker BB, McClellan RO (1983) Retention of monodisperse or poly-disperse aluminosilicate particles inhaled by dogs, rats and mice. Toxicol Appl Pharmacol 26:264–273

    Google Scholar 

  62. Bailey MR, Kreyling WG, Andre S, Batchelor A, Black A, Collier CG, Drosselmeyer E, Ferron GA, Foster P, Haider B, Hodgson A, Metivier H, Moores SR, Morgan A, Muller HL, Patrick G, Pearman I, Pickering S, Ramsden D, Stirling C, Talbot RG (1985) EULEP interspecies comparison of the lung clearance of inhaled cobalt oxide particles: interim summary of the results. Inhaled Particles VI, proceedings of an international symposium organized by the British Occupational Hygiene Society, Cambridge, England, September 1985

    Google Scholar 

  63. Bond JA, Sun JD, Mitchell CE, Dutcher JS, Wolff RK, McClellan RO (1986) Biological fate of inhaled organic compounds associated with particulate matter. In: Lee SD, Schneider T, Grant LD, Verkerk PJ (eds) Aerosols: Research, risk assessment and control strategies, Lewis, Chelsea, Michigan, pp 579–592

    Google Scholar 

  64. Bond JA, Baker SM, Bechtold WE (1985) Correlation of the octanol/water partition with clearance half-times of intratracheally instilled aromatic hydrocarbons in rats. Toxicology 36:285–295

    Article  PubMed  CAS  Google Scholar 

  65. Medinsky MA, Cheng YS, Kampcik SJ, Henderson RF, Dutcher JS (1986) Disposition and metabolism of 14C-solvent yellow and solvent green aerosols after inhalation. Fundam Appl Toxicol 7:170–178

    Article  PubMed  CAS  Google Scholar 

  66. Bond JA (1986) Factors modifying the disposition of inhaled organic compounds. Paper presented at the 4th Inhalation Toxicology Workshop held in Albuquerque, NM, October 1986

    Google Scholar 

  67. Mewhinney JA, Griffith WC (1982) Models of Am metabolism in beagles and humans. Health Phys 42:629–644

    Article  PubMed  CAS  Google Scholar 

  68. International Commission on Radiological Protection: Report of Committee 2 (1979) Limits for intakes of radionuclides by workers. Pergamon, Oxford

    Google Scholar 

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Author information

Authors and Affiliations

  1. Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute, P.O. Box 5890, Albuquerque, NM, 87185, USA

    R. G. Cuddihy & H. C. Yeh

Authors
  1. R. G. Cuddihy
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  2. H. C. Yeh
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Editor information

Editors and Affiliations

  1. Department of Veterinary Pathology, University of California, Davis, CA, 95616, USA

    Donald L. Dungworth Ph.D. M.R.C.V.S

  2. Bayer AG, Institute for Toxicology, 5600, Wuppertal-Elberfeld, Germany

    Georg Kimmerle Dr.med.

  3. Abbott Laboratories, Abbott Park, IL, 60064, USA

    James Lewkowski M.D.

  4. Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute, P.O. Box 5890, Albuquerque, NM, 87185, USA

    Roger O. McClellan D.V.M.

  5. Fraunhofer Institute of Toxicology and Aerosol Research, Nikolai-Fuchs-Strasse 1, 3000, Hannover 61, Germany

    Werner Stöber Dr.rer.nat.

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© 1988 Springer-Verlag New York Inc.

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Cuddihy, R.G., Yeh, H.C. (1988). Respiratory Tract Clearance of Particles and Substances Dissociated from Particles. In: Dungworth, D.L., Kimmerle, G., Lewkowski, J., McClellan, R.O., Stöber, W. (eds) Inhalation Toxicology. ILSI Monographs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61355-5_11

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  • DOI: https://doi.org/10.1007/978-3-642-61355-5_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64806-9

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