Abstract
The atherogenic potential of elevated serum cholesterol levels is nowadays well established. Persons with hypercholesterolemia, usually in the form of elevated low density lipoprotein (LDL) levels, run a higher risk of developing atherosclerotic lesions than normocholesterolemic subjects of the same age. Patients with the autosomal dominant trait of familial hypercholesterolemia (FH) exhibit dramatically elevated LDL levels and are prone to massive and premature atherosclerosis. Untreated patients homozygous for FH frequently die of myocardial infarction in early childhood (Table 1).
The author is a recipient of grants from the Deutsche Forschungsgemeinschaft and from the Wissenschaftliches Herausgeberkollegium der Münchener Medizinischen Wochenschrift e. V.
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References
Basu SK, Goldstein JL, Anderson RGW, Brown MS (1976) Proc Natl Acad Sci USA 73:3178–3182
Brown MS, Goldstein JL (1986) Science 232:34–47
Brown MS, Basu SK, Falck RR, Ho YK, Goldstein JL (1980) J Supramol Struct 13:67–81
Cathcart MK, Morel DW, Chisolm GM (1985) J Leukocyte Biol 38:341–350
Clayman RV, Bilhartz LE, Spady DK, Buja LM, Dietschy JM (1986) FEBS Lett 196, 1:87–90
Dresel HA, Friedrich E, Via DP, Schettler G, Sinn H (1985) EMBO J 4,5:1157–1162
Fagiotto A, Ross R (1984) Arteriosclerosis 4:341–356
Fagiotto A, Ross R, Harker L (1984) Arteriosclerosis 4:323–340
Fogelmann AM, Schechter I, Seager J, Hokom J, Child JS, Edwards PA (1980) Proc Natl Acad Sci USA 76:2214–2218
Friedman M, Byers SO, St George S (1962) J Clin Invest 41:828–841
Gerrity RG (1981 a) Am J Pathol 103:181–190
Gerrity RG (1981 b) Am J Pathol 103:191–200
Goldstein JL, Ho YK, Basu SK, Brown MS (1979) Proc Natl Acad Sci USA 76:333–337
Goldstein JL, Hoff HF, Ho YK, Basu SK, Brown MS (1981) Arteriosclerosis 1:210–226
Harders-Spengel K, Wood CB, Thompson GR, Myant NB, Soutar AK (1982) Proc Natl Acad Sci USA 79:6355–6359
Heinecke J, Baker L, Rosen H, Chait A (1986) J Clin invest 77:757–761
Henricksen T, Mahoney EM, Steinberg D (1981) Proc Natl Acad Sci USA 78:6499–6503
Laemmli UK (1970) Nature 227:680–685
McFarlane AS (1958) Nature 182:53
Nagelkerke JF, Barto KP, van Berkel TJC (1983) J Biol Chem 258:12221–12227
Niehaus C, Nicoli A, Wootton R, Jamieson CW, Lewis J, Lewis B (1977) Lancet II:693–642
Parthasarathy S, Printz DJ, Boyd D, Joy L, Steinberg D (1986) Arteriosclerosis 6:505–510
Peterson C, Vitols S, Rudling M, Blongren H, Edsmyr S, Skoog L (1985) Med Oncol Tumor Pharmacother 2:143–147
Pitas RE, Boyles J, Mahley RW, Bissel DM (1985) J Cell Biol 100:103–117 Quinn MT, Parthasarathy S, Steinberg D (1985) Proc Natl Acad Sci USA 82:5949–5953
Ross R (1986) N Engl J Med 314:488–500
Smith EB (1974) Adv Lipid Res, 12:1–49
Smith EB (1977) Am J Pathol 86:665–674
Smith EB, Slater RS (1972) Lancet I:463–469
Smith EB, Staples EM (1980) Proc R Soc Lond [Biol] 217:59–75
Soutar AK, Harders-Spengel K, Wade DP, Knight BL (1986) J Biol Chem 261:17127–17133
Soutar AK, Knight BL (1982) Biochem J 204:549–556
Spengel FA, Jadhav A, Wood C, Thompson GR (1981) Lancet II:768–770
Steinberg D (1983) Arteriosclerosis 3:283–301
Stender S, Zilversmit DB (1982) Arteriosclerosis 2:493–499
Thompson GR, Soutar AK, Spengel FA, Jadhav A, Gavigan SJP, Myant NB (1981) Proc Natl Acad Sci USA 78:2591–2595
Towbin H, Staehelin T, Gordon J (1979) Proc Natl Acad Sci USA 76:4350–4354
Via DP, Dresel HA, Gotto AM (1986) Methods Enzymol 129:216–226
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This paper is dedicated to Professor Dr. Nepomuk Zöllner on the occasion of his 65th birthday. I am grateful for his continued encouragement and support over the last 10 years.
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© 1989 Springer-Verlag Berlin Heidelberg
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Harders-Spengel, K. (1989). Visualization and Characterization of the Scavenger Receptor in Human Liver. In: Wolfram, G. (eds) Genetic and Therapeutic Aspects of Lipid and Purine Metabolism. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61322-7_4
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DOI: https://doi.org/10.1007/978-3-642-61322-7_4
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