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Diabetes, the Kidney, and Hypertension

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Renovascular and Renal Parenchymatous Hypertension

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Abstract

It is a well-known phenomenon in most renal diseases that elevation of blood develops when some reduction in renal function is evident. This is also the case within the field of diabetic nephropathy, but a very special and characteristic feature is that some elevation of blood pressure is seen quite early in the course, in fact before the fall of glomerular filtration rate (GFR) is established. In patients with microalbuminuria, where GFR is quite well maintained or even supranormal, an elevation of blood pressure is seen, in the order of 10% [25]. Some controversy exists regarding genetic predisposition to hypertension and early elevation of blood pressure in the course of diabetes [30]. Late in the course it seems clear that progression of nephropathy, measured as a fall in GFR, is correlated to systemic blood pressure, and this concept was originally introduced into nephrology from diabetology [23]. However, it now appears that the same association betwenn high blood pressure and progression of renal disease also exists in a number of renal diseases, irrespective of their initial genesis [1].

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Authors
  1. C. E. Mogensen
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Editors and Affiliations

  1. Departement Innere Medizin, Kantonsspital Basel Petersgraben 4, CH-4031, Basel, Switzerland

    Thomas F. Lüscher

  2. University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, 75 235-8899, Dallas, TX, USA

    Norman Meyer Kaplan

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© 1992 Springer Verlag, Berlin Heidelberg

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Mogensen, C.E. (1992). Diabetes, the Kidney, and Hypertension. In: Lüscher, T.F., Kaplan, N.M. (eds) Renovascular and Renal Parenchymatous Hypertension. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61239-8_23

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  • DOI: https://doi.org/10.1007/978-3-642-61239-8_23

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64756-7

  • Online ISBN: 978-3-642-61239-8

  • eBook Packages: Springer Book Archive

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