Abstract
The recent discovery that certain antibiotics can specifically interfere with catalytic or functional RNAs, besides the well-known example of ribosomal RNA, led to a new aspect in studying RNA structure and function. Simple amino sugars were added to the list of components influencing catalytic RNAs. Although several experiments pointed to a direct interaction of antibiotics with the ribosomal RNA, the presence of ribosomal proteins excluded a safe and conclusive confirmation of this assumption. The discovery that the catalytic reaction of group I intron RNA is sensitive to aminoglycosides provided clear evidence for a direct interaction with RNA and led to the initial suggestion of a possible evolutionary relationship between these two molecules, rRNA, and group I intron RNA. It also initiated a search for other RNA targets of antibiotics. Antibiotics are commonly known as low molecular weight products encompassing a wide range of different chemical classes from the secondary metabolism of microorganisms, able to inhibit growth of other microorganisms. Most of the effects on RNA function that were found are caused by aminoglycoside antibiotics — more specifically, by the disubstituted 2-deoxystreptamines (Fig. 1) — and we will therefore focus here on those compounds. Additionally, streptomycin, an aminocyclitol which is structurally related to aminoglycosides and which causes similar effects on translation, will be discussed.
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Schroeder, R., von Ahsen, U. (1996). Interaction of Aminoglycoside Antibiotics with RNA. In: Eckstein, F., Lilley, D.M.J. (eds) Catalytic RNA. Nucleic Acids and Molecular Biology, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61202-2_4
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DOI: https://doi.org/10.1007/978-3-642-61202-2_4
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