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Guillain-Barré syndrome: clinical and immunological aspects

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Immunoneurology

Abstract

Guillain-Barré syndrome (GBS), as we recognize it today, was first described by Landry in 1859 [32] and for years was known as Landry’s ascending paralysis. In 1916, Guillain, Barré and Strohl [23], using the newly developed technique of lumbar puncture, described albuminocytological dissociation, i.e., increased albumin with very few or no cells, in the cerebrospinal fluid of patients with Landry’s ascending paralysis and helped to distinguish the disorder from other paralytic disorders especially poliomyelitis. Over the next several years, Landry’s ascending paralysis with new diagnostic features in the cerebrospinal fluid (CSF) became kown as Guillain-Barré syndrome.

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  1. Department of Neurology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PN, 19104, USA

    A. M. Rostami

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  1. Clinique de Neurologie, Hôpital Cantonal Universitaire, CH-1211, Genève 14, Switzerland

    Michel Chofflon

  2. Department of Neurology, Stanford University, Stanford, California, 94305-5235, USA

    Lawrence Steinman

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Rostami, A.M. (1996). Guillain-Barré syndrome: clinical and immunological aspects. In: Chofflon, M., Steinman, L. (eds) Immunoneurology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61191-9_4

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