Abstract
Autoreactive T cells are part of the normal lymphocyte repertoire of healthy individuals [4]. In the immune system of healthy individuals, potent regulatory mechanisms control T and B cell tolerance to self antigens. While genetic factors influence susceptibility to autoimmunity in humans and experimental animals, environmental factors contribute to disease penetration. For autoimmune disease to occur, autoreactive lymphocytes have to be activated in vivo or in vitro. This process leads to the clonal expansion of autoreactive cells. In addition, during the initiation phase of demyelinating disease, only activated autoreactive lymphocytes migrate through the endothelial cell layer of the intact blood-brain barrier (BBB).
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© 1996 Springer-Verlag Berlin Heidelberg
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Brocke, S., Piercy, C., Steinman, L. (1996). Superantigens in demyelinating disease. In: Chofflon, M., Steinman, L. (eds) Immunoneurology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61191-9_13
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DOI: https://doi.org/10.1007/978-3-642-61191-9_13
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