Tumor Biology pp 295-307 | Cite as

Regulation of Murine Erythroleukemia Cell Differentiation

  • Asterios S. Tsiftsoglou
  • Ioannis S. Vizirianakis
  • Ioannis S. Pappas
Part of the NATO ASI Series book series (volume 99)

Abstract

It has been evident over the past three decades that virus-transformed hematopoietic cells represent progenitor cells unable to differentiate but capable to rapidly proliferate and give rise to leukemias. Such cells have been envisioned as cells deviated from the normal pathway of growth and differentiation and lost their responsiveness to physiological regulators (growth factors) (Sachs, 1980). In most cases leukemic cells appear to be less differentiated or undifferentiated, exhibit karyotypic abnormalities and fail to produce molecules characteristic of their differentiated phenotype.

Keywords

Leukemia Pyridine Nucleoside Homocysteine Hydrolase 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • Asterios S. Tsiftsoglou
    • 1
  • Ioannis S. Vizirianakis
    • 1
  • Ioannis S. Pappas
    • 1
  1. 1.Laboratory of Pharmacology, Department of Pharmaceutical SciencesAristotle University of ThessalonikiMacedoniaGreece

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