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Tumor Biology pp 273–283Cite as

Role of Intracellular Interleukin-6 in Growth Factor-Induced Cell Proliferation

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Part of the book series: NATO ASI Series ((ASIH,volume 99))

Abstract

The tight control of cell proliferation is essential during embryogenesis, development, wound repair and maintenance of tissue structure. These control mechanisms involve the communication of each single cell with its neighbouring cells via interleukins and cytokines. These molecules exert their functions through specific membrane receptors which induce activation of intracellular signalling proteins upon activation by their specific agonists. Disturbance or disruption of this control mechanisms are believed to result in abnormal cell proliferation as observed in various diseases that correlate with proliferative disorders such as hyperdermia, fibrosis, atherosclerosis, glomerulonephritis, and tumorigenesis. Regardless whether the dividing cell is of transformed or non-transformed origin, the basic cellular events triggering cell proliferation are the same.

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Authors and Affiliations

  1. Laboratory of Pneumology, Department of Research, University Hospital Basel, Hebelstrasse 20, CH-4031, Basel, Switzerland

    Michael Roth

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  1. Michael Roth
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Editor information

Editors and Affiliations

  1. Laboratory of Pharmacology, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, 54006, Thessaloniki, Greece

    Asterios S. Tsiftsoglou

  2. Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, 06510, New Haven, CT, USA

    Alan C. Sartorelli

  3. Department of Biology, Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, E17-536, 02139, Cambridge, MA, USA

    David E. Housman

  4. Department of Experimental Hematology, Christie Hospital, NHS Trust Paterson Institute for Cancer Research, Wilmslow Road, M20 9BX, Manchester, UK

    T. Michael Dexter

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© 1996 Springer-Verlag Berlin Heidelberg

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Roth, M. (1996). Role of Intracellular Interleukin-6 in Growth Factor-Induced Cell Proliferation. In: Tsiftsoglou, A.S., Sartorelli, A.C., Housman, D.E., Dexter, T.M. (eds) Tumor Biology. NATO ASI Series, vol 99. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61180-3_25

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  • DOI: https://doi.org/10.1007/978-3-642-61180-3_25

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64735-2

  • Online ISBN: 978-3-642-61180-3

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