Abstract
Adhesion molecules are an essential prerequisite for the development of multicellular organisms (Edelman1983,1986;Yap et al. 1994). They are now known to guide morphogenesis and organogenesis and are involved in the maintenance of organ structures (Anderson 1990;Hynes 1992a; Knudson and Knudson 1993; Nathke et al. 1993). Adhesion molecules are of the utmost importance for most functional activities of the immune system (Springer 1990; Dustin and Springer 1991; Shimizu et al. 1992; Vestweber 1992; Ratner 1992; Clark et al. 1992; Pardi et al. 1992; Simmons et al. 1994) and are thought to be involved in tumor progression (Hemler 1990; Dedhar 1990; Johnson 1991; McCarthy et al. 1991; Rusciano and Burger 1992; Lester and McCarthy 1992; Evans 1992; Behrens 1993; Zetter 1993; Glinsky 1993; Miyasaka and Toyama-Sorimachi 1993; Giancotti and Mainiero 1994). The number of adhesion molecules discovered is still growing and at present they are grouped in five families: integrins, selectins, cadherins, the immunoglobulin (lg) superfamily, and hematopoetic cell adhesion molecules (HCAMM), the latter group including CD44 (Williams and Barclay 1988; Rutishauser et al. 1988; Yong and Khwaja 1990; Albelda and Buck 1990; Helmer 1990; Springer 1990; Geiger and Ayalan 1992; Postigo and Sanchez-Madrid 1993; Tuckwell et al. 1993; Carlos and Harlan 1994; Birchmeier and Behrens 1994;). Especially integrins, the lg superfamily, and HCAM consist of a multitude of members, a number which is increased by combinatorial variations of heterodimers and by changes in glycosylation and in the protein structure, frequently due to alternative splicing of pre-mRNA (Hoffman and Edelman 1983; Williams and Barclay 1998; Springer 1990; Haynes et al. 1991a;Haynes 1992b; Sonnenberg 1993; Lesley et al. 1993a;Screation et al. 1993).
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Zöller, M. (1996). Joint Features of Metastasis Formation and Lymphocyte Maturation and Activation. In: Günthert, U., Birchmeier, W. (eds) Attempts to Understand Metastasis Formation I. Current Topics in Microbiology 213/I and Immunology, vol 213/1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61107-0_14
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