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Teratogenic Effects of Alcohol:Current Status of Animal Research and in vitro Models

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Toxicology - From Cells to Man

Part of the book series: Archives of Toxicology ((TOXICOLOGY,volume 18))

Abstract

Alcohol consumption during pregnancy induces in the offspring a wide spectrum of adverse effects, the extreme consequence of which is the fetal alcohol syndrome (FAS), characterized by growth deficiency, altered morphogenesis, and central nervous system dysfunctions (Jones and Smith 1973). The incidence of FAS is estimated to be 1.9 per 1000 live births, and in Western societies alcohol consumption during pregnancy is considered to be the most prevalent cause of preventable mental retardation (Abel and Sokol 1987). Although in 20 years of basic and clinical research a wealth of information has been accumulated, there is a need for further definition and characterization of the prenatal effects of alcohol on the developing organism.

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Authors and Affiliations

  1. Instituto Investigaciones Citológicas (FIB), Amadeo de Saboya 4, 46010, Valencia, Spain

    Consuelo Guerri

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  1. Consuelo Guerri
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Editors and Affiliations

  1. Interkantonale Kontrollstelle für Heilmittel, Erlachstrasse 8, CH-3000, Bern 9, Switzerland

    Jürg P. Seiler

  2. Department of Pharmacology, Charles University of Prague, 3rd Medical School, Ruská 87, Czech Republic

    Olga Kroftová

  3. Department of Pharmacology, Charles University, Faculty of Medicine, Karlovarská 48, CZ-30166, Pilsen, Czech Republic

    Vladislav Eybl

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© 1996 Springer-Verlag Berlin Heidelberg

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Guerri, C. (1996). Teratogenic Effects of Alcohol:Current Status of Animal Research and in vitro Models. In: Seiler, J.P., Kroftová, O., Eybl, V. (eds) Toxicology - From Cells to Man. Archives of Toxicology, vol 18. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61105-6_8

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  • DOI: https://doi.org/10.1007/978-3-642-61105-6_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64696-6

  • Online ISBN: 978-3-642-61105-6

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