Abstract
Cadmium occupies a special position among all toxic metals found in the environment and used in industry (Nordberg et al. 1985). It has a long biological half-life and is excreted very slowly from its soft tissue deposits. The ability to induce metallothionein (MT) and to form stable intracellular MT complexes makes the mobilization of Cadmium by chelation, particularly with regard to chronic exposure, extremely difficult.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Andersen O (1984) Chelation of cadmium. Environ. Health Perspect., 54 249
Bláha Jr K, Cikrt M, Kašparova L and Jones MM (1988) Synergistic enhancement of the biliary excretion of cadmium by the simultaneous administration of two dithiocarbamates. Toxicology Lett. 42: 207
Bláha K, Nerudová J, Jehlicková H, Cikrt M, Jones MM and Singh PK (1995) In vivo and in vitro efficacy of a new carbodithioate for the mobilization of cadmium. J. Tox.Environ. Health, 44: 87
Cantilena Jr LR, Irwin G, Preskorn S and Klaassen cadmium (1982) The effect of diethyldithiocarbamate on brain uptake of cadmium. Toxicol. Appl. Pharmacol. 63: 338
Cherian MG(1980) Chelation of cadmium with BAL and DTP A. Nature 287: 871
Cherian MG, Onosaka S, Carson GK and Dean PAW (1982) Biliary excretion of cadmium in rat V. Effects of structurally related mercaptans on chelation of cadmium from metallothionein, J. Toxicol. Environ. Health, 9: 389
Cikrt M, Basinger MA, Jones SG and Jones MM (1986) Structural effects in the dithiocarbamate enhanced biliary excretion of cadmium. J. Toxicol. Environ. Health 17: 429
Cikrt M, Bláha K, Nerudová J, Bittnerová D, Jehlicková H and Jones MM (1992) Distribution and excretion of cadmium and nickel after simultaneous exposure and the effect of N-Benzyl-D-Glucamine Dithiocarbamate od Their Biliary and urinary excretion. J.Tox. Environ. Health, 35: 211 – 220
Cikrt M, Lepsi P, Bittnerova D and Jones MM (1984) The effect of sodium diethaolamine dithiocarbamation distribution and excretion of cadmium in rats drinking cadmium-containing water. Res. Commun. Chem. Pathol. Pharmacol., 43: 497
Cikrt M, Lepši P, Horáková L, Bláha K, Jr, Bittnerová D and Jones MM (1986) Effects of dithiocarbamates on cadmium distribution and excretion in chronically exposed rats., J.Tox.Environ Health, 17: 419
Cherian MG (1980) Chelation of cadmium with BAL and DTP A. Nature 287: 871
Cherian MG, Onosaka S, Carson GK and Dean PAW (1982) Biliary excretion of cadmium in rat V. Effects of structurally related mercaptans on chelation of cadmium from metallothionein, J. Toxicol. Environ. Health, 9: 389
Dalhamn T and Friberg L (1955) Dimercaprol (2,3-dimercaptopropanol) in chronic cadmium poisoning. Acta Pharmacol. Toxicol.: 1168
Eybl V, Sykora J and Mertl F (1966) Einfluss der Chelatbildner auf die Ausscheidung des Cadmiums bei Cadmiumvergiftung. Nauyn Schmids Arch. Exp. Pathol. Pharmakol.: 252
Gilman A, Philips FS, Allen RP and Koelle ES (1946) The treatment of acute cadmium intoxication in rabbits with 2,3-dimercaptopropanol (BAL) and other mercaptans. J. Pharmacol Exp. Ther. 87, Suppl. No. 4: 85
Jones MM and Cherian MG (1990) The search for chelate antagonists for chronic cadmium intoxication. Toxicology 62: 1
Jones SG and Jones MM (1984) Structure activity relationship among dithiocarbamate antidotes for acute cadmium chloride intoxications. Environ. Hlth. Persp. 54: 285
Jones SG, Jones MM, Basinger MA, Burka LT and Shinobu LA (1983) Polarity and antidotal efficacy of dithiocarbamates in acute cadmium intoxication. Res. Comm. Chem. Pathol and Pharmacol. 40: 1
Jones MM, Singh PM, Jones SG (1990) Optimization of chelatating agent structure for the mobilization of aged renal and hepatic cadmium deposits: N-benzyl-4-0-(N- 0-galactopyranosyl)-D-glucamine-N-carbodithioate. Chem. Res. Toxicol 3: 248
Jones SG, Singh PK and Jones MM (1988) Use of the Topliss scheme for the design of more effective chelating agents for cadmium decorporation. Chem. Res. Toxicol. 1: 234
Kojima S, Kiyozumi M and Saito K (1981) Studies on poisonous metals. II Effect of chelating agents on excretion of cadmium through bile and gastrointestinal mucosa in rats. Chem. Pharm. Bull. 21: 16
Nordberg GF (1984) Chelating agents and cadmium toxicity, problems and prospects. Environ. Health Persp. 54: 213
Shimada H, Kamenosono T, Kawagoe M, Funakoshi T, Kiyozumi M, Takadate A and Kojima S (1991) Mobilization of Renal and Hepatic Cadmium by Dithiocarbamates in Rats. J. Pharmacobio-Dyn., 14: 555
Shinobu LA, Jones SG and Jones MM (1984) Sodium N-methyl-D-glucamine dithiocarbamate and cadmium intoxication. Acta Pharmacol. Toxicol. 54: 189#
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Bláha, K., Cikrt, M. (1996). Mobilizers of Stored Cadmium. In: Seiler, J.P., Kroftová, O., Eybl, V. (eds) Toxicology - From Cells to Man. Archives of Toxicology, vol 18. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61105-6_20
Download citation
DOI: https://doi.org/10.1007/978-3-642-61105-6_20
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-64696-6
Online ISBN: 978-3-642-61105-6
eBook Packages: Springer Book Archive