Abstract
Since function and dysfunction in the central nervous system are only expressed as a result of the activity of neurones, it is easy to overlook the contribution of other cell types. The specialised brain vasculature, ventricular system, and glial network make a vital contribution to brain function, and also represent additional targets for neurotoxic agents. Given the complex physiological relationships between these different cell types one should expect to find correspondingly complex toxicological relationships also. We set out to examine the extent to which functional changes in one cell type (neurones) could influence the susceptibility of another cell type (astrocytes) to toxic agents.
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© 1996 Springer-Verlag Berlin Heidelberg
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Ray, D.E., Holton, J.L., Lister, T., Nolan, C.C. (1996). The Glio-Vascular Toxicity of m -Dinitro- Benzene and Related Agents: Modulation of Toxicity by Neuronal Activation. In: Seiler, J.P., Kroftová, O., Eybl, V. (eds) Toxicology - From Cells to Man. Archives of Toxicology, vol 18. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61105-6_15
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DOI: https://doi.org/10.1007/978-3-642-61105-6_15
Publisher Name: Springer, Berlin, Heidelberg
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