Abstract
The recent success of perinatal medicine in protecting high-risk pregnacies and in saving the lives of very immature and injured fetuses/newborns is connected with a substantial increase in the use of drugs in obstetrics and neonatology. However, minimal attention has been paid so far to the potential teratogenic risk of these drugs for the developing fetal brain and immune system. After all, why care, when all drug information leaflets, and even textbooks of pharmacology, claim that the drug teratogenicity risk is restricted to the first trimester of gravidity. Is it really so?
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Benešová O, Pavlík A (1989) Perinatal treatment with glucocorticoids and the risk of maldevelopment of the brain. Neuropharmacology 28: 89–97
Benešová O, Pavlík A, Pìtová J (1984) Brain Maldevelopment and Drugs. Avicenum, Prague
Benešová O, Tejkalová H, Burešová M (1992) Accelerated brain aging in rats as a consequence of disturbed perinatal development induced by drugs. In: Trojan S, Lngmeier M (eds) Ontogenesis of the Brain. Vol. 5. Universitas Carolina Pragensis, Prague, pp 135–139
Benešová O, Tejkalová H, Krištofiková Z, Klaschka J, Dostál M (1994) Early postnatal diazepam treatment of rats and neuroimmunocompetence in adult-hood and senescence. Annals New York Academy of Sciences, 717: 89–101
Dobbing J (1970) Undernutrition and the developing brain. In: Himwich WA (ed) Developmental Neurobiology. Thomas, Springfield, pp 241–261
Dostal M, Benešová O., Tejkalová H, Soukupová D (1995) Immune response of adult rats is altered by administration of diazepam in the first postnatal week. Reproductive Toxicol. 9: 115–121
Jelínek R, Pavlik A, Peterka M (1983) Glucocorticoid receptor mediated terato-genesis in the chick embryo. Teratogenesis, Carcinogenesis and Mutagenesis 3: 1–7
Jelínek R, Rychter Z (1980) Morphogenetic systems and screening for embryo-toxicity. Arch. Toxicol. (Suppl.) 4: 267–273
Tejkalová H, Benešová O, Krištofiková Z, Binková B, Dlohozková N, Burešová M (1991) The assessment of the behavioural teratogenic risk of the tocolytic drug fenoterol. Homeostasis 33: 89–93
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Benešová, O. (1996). Drug Treatment in the Perinatal Period and the Risk of Functional Teratogenicity. In: Seiler, J.P., Kroftová, O., Eybl, V. (eds) Toxicology - From Cells to Man. Archives of Toxicology, vol 18. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61105-6_10
Download citation
DOI: https://doi.org/10.1007/978-3-642-61105-6_10
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-64696-6
Online ISBN: 978-3-642-61105-6
eBook Packages: Springer Book Archive