New Concepts of Schizophrenia Derived from Epidemiological Research

  • H. Häfner
Conference paper

Abstract

When I received the honourable invitation as one of the two indigenous speakers to present a lecture in honour of my friend Hanns Hippius for his 70th birthday at this holy place, I got the uneasy feeling that something remarkable was expected of me. Also worried by the fact that I had been included with an ambitious epidemiological topic in a purely psychopharmacological programme, I realised that I owed my friend at least a brief glimpse of the biological depths from the epidemiological surface - the more so since our great forerunner Sigmund Freud had tried in vain to fish for the causes of schizophrenia with his psychoanalytic hook, finding merely his own mirror image staring at him from the depths.

Keywords

Depression Estrogen Dopamine Dementia Income 

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References

  1. Angermeyer MC, Kühn L (1988) Gender differences in age at onset of schizophrenia. Eur Arch Psychiatr Neurol Sci 237: 351–364CrossRefGoogle Scholar
  2. Biehl H, Maurer K, Schubart C, Krumm B, Jung E (1986) Prediction of outcome and utilization of medical services in a prospective study of first onset schizophrenics - results of a prospective 5-year follow-up study. Eur Arch Psychiatry Neurol Sci 236: 139–147PubMedCrossRefGoogle Scholar
  3. Choquet M, Ledoux S (1994) Epidemiologie et adolescence. In: Confrontations psychiatriques, vol 27, (no 35 ). Rhone-Poulenc rorer specia, Paris, pp 287–309Google Scholar
  4. DiPaolo T, Falardeau P (1985) Modulation of brain and pituitary dopamine receptors by estrogens and prolactin. Prog Neuropsychopharmacol Biol Psychiatry 9: 473–480PubMedCrossRefGoogle Scholar
  5. Dohrenwend BP, Levav I, Shrout PE, Schwartz S, Naveh G, Link BG, Skodol AE, Stueve A (1992) Socioeconomic status and psychiatric disorders: the causation-selection issue. Science 255: 946–952PubMedCrossRefGoogle Scholar
  6. Fields JZ, Gordon JH (1982) Estrogen inhibits the dopaminergic supersensitivity induced by neuroleptics. Life Sci 30: 229–234PubMedCrossRefGoogle Scholar
  7. Häfner H, Riecher A, Maurer K, Löffler W, Munk-Jøgensen P (1989) How does gender influence age at first hospitalization for schizophrenia? A transnational case register study. Psychol Med 19: 903–918PubMedCrossRefGoogle Scholar
  8. Häfner H, Riecher A, Maurer K, Meissner S, Schmidtke A, Fätkenheuer B, Löffler W, an der Heiden W (1990) Ein Instrument zur retrospektiven Einschätzung des Erkrankungsbeginns bei Schizophrenie (instrument for the retrospective assessment of the onset of schizophrenia) - „IRAOS“- Entwicklung und Ergebnisse. Z Klin Psychol 19: 230–255Google Scholar
  9. Häfner H, Behrens S, De Vry J, Gattaz WF (1991a) An animal model for the effects of estradiol on dopamine-mediated behavior: implications for sex differences in schizophrenia. Psychiatry Res 38: 125–134PubMedCrossRefGoogle Scholar
  10. Häfner H, Behrens S, de Vry J, Gattaz WF, Löffler W, Maurer K, Riecher-Rössler A (1991b) Warum erkranken Frauen später an Schizophrenie? Nervenheilkunde 10: 154–163Google Scholar
  11. Häfner H, Riecher-Rössler A, Hambrecht M, Maurer K, Meissner S, Schmidtke A, Fätkenheuer B, Löffler W, an der Heiden W (1992) IRAOS: an instrument for the assessment of onset and early course of schizophrenia. Schizophr Res 6: 209–223PubMedCrossRefGoogle Scholar
  12. Häfner H, Riecher-Rössler A, Hambrecht M, Maurer K, Meissner S, Schmidtke A, Fätkenheuer B, Löffler W, an der Heiden W (1992) IRAOS: an instrument for the assessment of onset and early course of schizophrenia. Schizophr Res 6: 209–223PubMedCrossRefGoogle Scholar
  13. Hambrecht M, Maurer K, Sartorius N, Häfner H (1992) Transnational stability of gender differences in schizophrenia? An analysis based on the WHO study on determinants of outcome of severe mental disorders. Eur Arch Psychiatry Clin Neurosci 242: 6–12PubMedCrossRefGoogle Scholar
  14. Harrer S (1987) Über das Zusammenwirken von Ostradiol und Dopamin bei der Verhaltenssteuerung von Säugern. Thesis, University of StuttgartGoogle Scholar
  15. Henn FA, McKinney WT (1987) Animal models in psychiatry. In: Meitzer HY (ed) Psychopharmacology: the third generation of progress. Raven, New York, pp 687–695Google Scholar
  16. Jablensky A, Sartorius N, Ernberg G, Anker M, Korten A, Cooper JE, Day R, Bertelsen A (1992) Schizophrenia: manifestations, incidence and course in different cultures. A World Health Organization ten-country study. Psychol Med Monogr Suppl 20Google Scholar
  17. Kraepelin E (1909–1915) Psychiatrie, 8th edn, vols 1–4. Barth, LeipzigGoogle Scholar
  18. Lindelius R (1970) A study of schizophrenia. Acta Psychiatr Scand Suppl 216Google Scholar
  19. Riecher-Rössler A, Häfner H, Stumbaum M, Maurer K, Schmidt R (1994) Can estradiol modulate schizophrenic symptomatology? Schizophr Bull 20: 203–214PubMedGoogle Scholar
  20. Salokangas RKR, Stengard E, Räkköläinen v, Kaijonen IHA (1987) New schizophrenic patients and their families ( English summary ). Psychiatr Fenn 78: 119–216Google Scholar
  21. Shepherd M, Watt D, Falloon I, Smeeton N (1989) The natural history of schizophrenia: a five- year follow-up study of outcome and prediction in a representative sample of schizophrenics. Psychol Med Monogr Suppl 15Google Scholar
  22. Strömgren E (1935) Zum Ersatz des Weinbergschen „abgekürzten Verfahrens“. Zugleich ein Beitrag zur Frage von der Erheblichkeit des Erkrankungsalters bei der Schizophrenie. Zeitschr Gesamte Neurol Psychiatr 153: 784–797CrossRefGoogle Scholar
  23. Sumner BEH, Fink G (1995) Oestradiol-i7ß in its positive feedback mode significantly increases 5-HT2a receptor density in the frontal, cingulate and piriform cortex of the female rat. J Physiol (Lond) 483: 52Google Scholar
  24. Tsuang MT, Fleming JA (1987) Long-term outcome of schizophrenia and other psychoses. In: Häfner H, Gattaz WF, Janzarik W (eds) Search for the causes of schizophrenia. Springer, Berlin Heidelberg New York pp 88–97Google Scholar
  25. Woolley CS, McEwen BS (1994) Estradiol regulates hippocampal dendritic spine density via an N-Methyl-D-aspartate receptor-dependent mechanism. J Neurosci 14: 7680–7687PubMedGoogle Scholar

Copyright information

© Springer Verlag, Berlin Heidelberg 1996

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  • H. Häfner

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