Nasal Neoplasia

  • Kevin T. Morgan
  • Jack R. Harkema
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)

Abstract

The pathological features of nasal neoplasia in rats, mice, and hamsters has been extensively reviewed (Brown et al. 1991; Feron and Bosland 1989; Feron et al. 1990; Reznik and Stinson 1983). Tumors have been recorded for each of the major nasal epithelial types and a number of accessory structures, and some of these neoplasms are the subject of recent research on mechanisms of carcinogenesis. Toxicological pathology may contribute in a major way to this research through (a) determination of the site of origin of nasal tumors, (b) identification of the tissue or cell type from which they were derived, and (c) characterization of tumor progression from the earliest stages of the process. This paper outlines diagnostic issues of importance for nasal tumors, using selected examples. More detailed information is available in the literature cited. Throughout this text the anatomical identifiers are derived from classic anatomical texts (Hebel and Stromberg 1976; Negus 1958; Reznik 1983; Sorokin 1983), while the classification of the nasal meatuses and ethmoid turbinates are those proposed by Morgan et al. (1991) and Mery et al. (1994), respectively

Keywords

Formaldehyde Adenocarcinoma Pyrene Osteosarcoma Neuroblastoma 

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References

  1. Belinsky SA, Walker VE, Maronpot RR, Swenberg JA, Anderson MW (1987) Molecular dosimetry of DNA adduct formation and cell toxicity in rat nasal mucosa following exposure to the tobacco specific nitrosamine 4-(N-methyl-nitrosamino)-1-(3-pyridyl)-1-butanone and their relationship to induction of neoplasia. Cancer Res 47:6058–6065PubMedGoogle Scholar
  2. Bogdanffy MS (1990) Biotransformation enzymes in the rodent nasal mucosa: the value of a histochemical approach. Environ Health Perspect 85:177–186PubMedCrossRefGoogle Scholar
  3. Brown HR (1990) Neoplastic and potentially preneoplastic changes in the upper respiratory tract of rats and mice. Environ Health Perspect 85:291–304PubMedCrossRefGoogle Scholar
  4. Brown HG, Monticello TM, Maronpot RR, Randall HW, Hotchkiss JR, Morgan KT (1991) Proliferative and neoplastic lesions in the rodent nasal cavity. Toxicol Pathol 19:358–372PubMedGoogle Scholar
  5. Dahl AR, Hadley WM (1991) Nasal cavity enzymes involved in xenobiotic metabolism: effects on the toxicity of inhalants. Crit Rev Toxicol 21:345–372PubMedCrossRefGoogle Scholar
  6. Feron VJ, Bosland MC (eds) (1989) Nasal carcinogenesis in rodents: relevence to human health risk. Proceedings of the TNO-CIVO/NYU Nose Symposium, Veldhoven, Netherlands, 24–28 Oct 1988: Pudoc WageningenGoogle Scholar
  7. Feron VJ, Woutersen RA (1989) Role of tissue damage in nasal carcinogenesis. In: FeronVJ,BoslandMC (eds) Nasal carcinogenesis in rodents: relevance to human health risk. Proceedings of the TNO-CIVO/NYU Nose Symposium, Veldhoven, Netherlands, 24–28 Oct 1988, Pudoc Wageningen, pp 76–84Google Scholar
  8. Feron VJ, Woutersen RA, Spit BJ (1986) Pathology of chronic nasal toxic responses including cancer. In: BarrowCS (ed) Toxicology of the nasal passages. Hemisphere, Washington DC, pp 67–89Google Scholar
  9. Feron VJ, Woutersen RA, Van Garderen-Hoetmer A, Dreefvan der Meulen HC (1990) Upper respiratory tract tumors in Cpb:WU (Wistar random) rats. Environ Health Perspect 85:305–315PubMedCrossRefGoogle Scholar
  10. Hebel R, Strombert MW (1976) Anatomy of the laboratory rat. Williams and Wilkins, BaltimoreGoogle Scholar
  11. Holmström M, Lund VJ (1991)Malignant melanomas of the nasal cavity after occupational exposure to formaldehyde. Br J Ind Med 48:9–11PubMedGoogle Scholar
  12. Kerns WD (1985) Polypoid adenoma of the nasal cavity in the laboratory rat. In: JonesTC,MohrU,HuntRD (eds) Monographs on pathology of laboratory animals, respiratory system. Springer, Berlin Heidelberg New York, pp 41–47Google Scholar
  13. Kerns WD, Pavkov KL, Donofrio DJ, Grafia EJ, Swenberg JA (1983) Carcinogenicity of formaldehyde in rats mice after long-term inhalation exposure. Cancer Res 43:4382–4392PubMedGoogle Scholar
  14. Mery S, Gross EA, Joyner DR, GodoM,MorganKT (1994) Nasal diagrams: a tool for recording the distribution of nasal lesions in rats and mice. Toxicol Pathol 22:353–372PubMedCrossRefGoogle Scholar
  15. Morgan KT (1994) Nasal dosimetry, lesion distribution, and the toxicologic pathologist: a brief review. Inhal Toxicol 6:41–57CrossRefGoogle Scholar
  16. Morgan KT, Monticello TM (1990) Formaldehyde toxicity: respiratory epithelial injury and repair. In: ThomassenDG,NettesheimP (eds) Biology, toxicology, and carcinogenesis of respiratory epithelium. Hemisphere, New York, pp 155–171Google Scholar
  17. Morgan KT, Jiang XZ, Starr TB, KernsWD (1986) More precise localization of nasal tumors associated with chronic exposure of F-344 rats to formaldehyde gas. Toxicol Appi Pharmacol 82:264–271CrossRefGoogle Scholar
  18. Morgan KT, Kimbell JS, Monticello TM, Patra AL, Fleishman A (1991) Studies of inspiratory airflow patterns in the nasal passages of the F344 rat and rhesus monkey using nasal molds: relevance to formaldehyde toxicity. Toxicol Appi Pharmacol 110:223–240CrossRefGoogle Scholar
  19. Moulton JE (1978) Tumors of the respiratory system. In: MoultonJE (ed) Tumors in domestic animals, 2nd edn. California Press, Berkeley, pp 205–239Google Scholar
  20. Negus V (1958) The comparative anatomy and physiology of the nose and paranasal sinuses. Livingstone, EdinburghGoogle Scholar
  21. Patnaik AK (1989) Canine sinonasal neoplasms: clinicopathological study of 285 cases. J Am An Hosp Assoc 25:103–114Google Scholar
  22. Recio L, Sisk S, Pluta L, BermudezE,GrossEA,ChenZ,MorganKT,WalkerC (1992) Mutations in formaldehyde-induced nasal squamous cell carcinomas in rats. Cancer Res 52:6113–6116PubMedGoogle Scholar
  23. Reed CJ (1993) Drug metabolism in the nasal cavity: relevance to toxicology. Drug Metab Rev 173–205Google Scholar
  24. Reznik G (1983) Comparative anatomy and histomorphology of the nasal and paranasal cavities in rodents. In: ReznikG,StinsonSF (eds) Nasal tumors in animals and man, vol 1. CRC, Boca Raton, pp 35–44Google Scholar
  25. Reznik G, Stinson SF (1983) Comparative anatomy and histomorphology of the nasal and paranasal cavities in rodents. In: ReznikG,StinsonSF (eds) Nasal tumors in animals and man, vol 1. CRC, Boca Raton pp. 35–44Google Scholar
  26. Schoevers EJ, Kuijpers MH, Woutersen RA, Feron VJ (1994) Spontaneous squamous cell carcinoma of nasal and paranasal structures in the Cpb: WU (Wistar random) rat: nasolachrymal duct as major site of origin. J Environ Pathol Toxicol Oncol 13:49–57PubMedGoogle Scholar
  27. Schüller HM (1989) Nitrosamine-induced nasal cavity carcinogenesis in rodents. In: FeronVJ, BoslandMC (eds) Nasal carcinogeneses in rodents: Relevance to human health risk. Proceedings of the TNO-CIVO/NYU nose symposium, Veldhoven, Netherlands, 24–28 Oct 1988, Pudoc Wageningen, pp 63–9Google Scholar
  28. Sills RC, Morgan KT, Boorman GA (1994) Accessory nasal structures in toxicology studies. Inhal Toxicol (in press)Google Scholar
  29. Sorokin SP (1983) The respiratory system. In: WeissL (ed) Histology, cell and tissue biology, 5th edn. Elsevier Biomedical, New York, pp 788–868Google Scholar
  30. Uraih LC, Morgan KT, Maronpot RR (1990) Symposium on toxicologic pathology of the upper respiratory system. Environ Health Perspect 85:161–352CrossRefGoogle Scholar
  31. Woutersen RA, Appelman LM, Van Garderen-Hoetmer A, Feron VJ (1986) Inhalation toxicity of acetaldehyde in rats. III. Carcinogenicity study. Toxicology 41:213–231PubMedCrossRefGoogle Scholar
  32. Woutersen RA, Van Garderen-Hoetmer A, BruijntjesJP,ZwartA,FeronJ (1989) Nasal tumors in rats after severe injury to the nasal mucosa and prolonged exposure to 10ppm formaldehyde. J Appi Toxicol 9:39–46CrossRefGoogle Scholar
  33. Yuspa SH (1994) The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis-thirty-third GH. Cancer Res 54:1178–1189PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • Kevin T. Morgan
  • Jack R. Harkema

There are no affiliations available

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