Abstract
Mice. Gross lung changes are not seen in mice naturally infected with pneumonia virus of mice (PVM). Pulmonary consolidation has been produced experimentally using tissue culture adapted virus (Harter and Choppin 1967; Tennant et al. 1965) or serially blind-passed PVM-infected lung tissue (Horsfall and Hahn 1940; Curnen and Horsfall 1947). Initially, consolidation is hilar in distribution with subsequent radiation along bronchioles. Consolidated foci are dark red and exude sanguinous fluid when cut. Later these foci become gray. Athymic mice, which are susceptible to persistent PVM infection, develop lobar consolidation or diffuse pulmonary edema (Weir et al. 1988).
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Keywords
- Respiratory Syncytial Virus
- Interstitial Pneumonia
- Respiratory Syncytial Virus Infection
- Athymic Mouse
- Sendai Virus
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© 1996 Springer-Verlag Berlin Heidelberg
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Brownstein, D.G. (1996). Pneumonia Virus of Mice Infection, Lung, Mouse, and Rat. In: Jones, T.C., Dungworth, D.L., Mohr, U. (eds) Respiratory System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61042-4_36
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