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In Vitro Drug Interactions

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Book cover Mechanisms of Drug Interactions

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 122))

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Abstract

In vitro drug interactions may be defined as those interactions which occur outside the body. Drug interactions which will be discussed in this chapter are those which occur between drugs due to reasons of incompatibility (e.g., drug-drug interactions in an intravenous infusion), due to interaction of a drug with its packaging (e.g., drug binding to an infusion bag), due to loss of drugs during laboratory analyses (e.g., binding to laboratory equipment) or due to changes in the bioavailability of drugs when the formulation is altered (McElnay and D’Arcy 1980).

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References

  • Airaudo CB, Gaytesorbier A, Bianchi C, Verdier M (1993) Interactions between six psychotherapeutic drugs and containers: influence of plastic material and infusion solutions. Int J Clin Pharmacol Ther 31:261–266

    CAS  Google Scholar 

  • All wood MC (1986) The release of phthalate ester plasticizer from intravenous administrations sets into fat emulsion. Int J Pharm 29:233–236

    Article  CAS  Google Scholar 

  • Allwood MC (1994) Drug stability and intravenous administration, 2nd edn. Clinical pharmacy practice guide. UKCPA, University of Leeds Media Service, Leeds

    Google Scholar 

  • Altavela JL, Haas CE, Nowak DR, Powers J, Gacioch GM (1994) Clinical response to intravenous nitroglycerin infused through polyethylene or polyvinyl chloride tubing. Am J Hosp Pharm 51:490–494

    PubMed  CAS  Google Scholar 

  • Association of British Pharmaceutical Industry (ABPI) (19940 Data sheet compendium 1994/95. Datapharm, London

    Google Scholar 

  • Autain J (1963) Plastics in pharmaceutical practice and related fields, part I. J Pharm Sei 52:1–23

    Article  Google Scholar 

  • Baaske DM, Amann AH, Wagenknecht DM, Mooers, M, Carter JE, Hoyt HJ, Stoll RG (1980) Nitroglycerin compatibility with intravenous fluid filters, containers, and administration sets. Am J Hosp Pharm 37:201–205

    PubMed  CAS  Google Scholar 

  • Benvenuto JA, Anderson RW, Kerkof K, Smith RG, Loo TL (1981) Stability and compatibility of antitumor agents in glass and plastic containers. Am J Hosp Pharm 38:1914–1918

    PubMed  CAS  Google Scholar 

  • Birely AW, Scott M J (1982) Plastic materials, properties and applications. Blackie, Glasgow, pp 1–18

    Google Scholar 

  • Bonhomme L, Benhamou D, Beugre T (1992) Slow-release effect of pH-adjusted bupivacaine: in vitro demonstration. Int J Pharm 84:33–37

    Article  CAS  Google Scholar 

  • British National Formulary (1994) No 28. British Medical Association and Pharmaceutical Press, London

    Google Scholar 

  • British National Formulary (1995) No 29. British Medical Association and Pharmaceutical Press, London

    Google Scholar 

  • Brydson JA (1982) Plastics materials. Butterworth, London, pp 18 143

    Google Scholar 

  • Calne RY, White DRG, Thiru S (1978) Cyclosporin A in patients receiving renal allografts from cadaver donors. Lancet II:515–524

    Google Scholar 

  • Carter SJ (1975) Cooper and Gunn’s dispensing for pharmaceutical students, 12th edn. Pitman, London, pp 253–264

    Google Scholar 

  • Chen ML, Chiou WL (1982) Adsorption of methotrexate onto glassware and syringes. J Pharm Sei 71:129–131

    Article  CAS  Google Scholar 

  • Chiou WL, Moorhatch P (1973) Interaction between vitamin A and plastic intravenous bags. JAMA 223:328

    Google Scholar 

  • Chowhan ZT, Chi LH (1986a) Drug-excipient interactions resulting from powder mixing. IV. Role of lubricants and their effect on in vitro dissolution. J Pharm Sei 75:542–545

    Article  CAS  Google Scholar 

  • Chowhan ZT, Chi LH (1986b) Drug-excipient interactions resulting from powder mixing. III. Solid state properties and their effect on drug dissolution. J Pharm Sei 75:534–541

    Article  CAS  Google Scholar 

  • Collins JL, Lutz RJ (1991) In vitro study of simultaneous infusion of incompatible drugs in multilumen catheters. Heart Lung 20:271–277

    PubMed  CAS  Google Scholar 

  • Cooper J (1974) Plastic containers for pharmaceuticals testing and control. WHO, Geneva, pp 1–13

    Google Scholar 

  • Cossum PA, Roberts MS (1981) Availability of isosorbide dinitrate, diazepam and chlormethiazole from i v delivery systems. Eur J Clin Pharmacol 19:181–185

    Article  PubMed  CAS  Google Scholar 

  • DiLuccio RC, Hussain MA, Coffin-Beach D, Torosian G, Shefter E, Hurwitz AR (1994) Sustained-release oral delivery of theophylline by use of polyvinyl alcohol and polyvinyl alcohol-methyl acrylate polymers. J Pharm Sei 83:104–106

    Article  CAS  Google Scholar 

  • Drott P, Meurling S, Meurling L (1991) Clinical adsorption and photodegradation of the fat-soluble vitamin A and vitamin E. Clin Nutr 10:348–351

    Article  CAS  Google Scholar 

  • Durig T, Fassihi AR (1993) Identification of stabilizing and destabilizing effects of excipient-drug interactions in solid dosage form design. Int J Pharm 97:161–170

    Article  CAS  Google Scholar 

  • Elshattawy HH, Ahmed EI, Bayomi MA, Abdelfatah IM (1994) Piroxicam synthetic polymers interactions. Pharm Ind 56:396–399

    CAS  Google Scholar 

  • Ferrebee JW, Johnson BB, Mithoefer JC, Gardella JW (1951) Insulin and adrenocor- ticotropin labelled with radio-iodine. Endocrinology 48:277–283

    Article  PubMed  CAS  Google Scholar 

  • Fletcher S, Summers RS (1980) Physical and dissolution characteristics and bioavailability of five brands of digoxin tablets. S Afr Med J 57:530–533

    PubMed  CAS  Google Scholar 

  • Fournier C, Hecquet B, Bastian G, Khayat D (1992) Modification of the physicochemical and pharmacological properties of anticancer platinum compounds by commercial 5-fluorouracil formulations — a comparative study using cisplatin and carboplatin. Cancer Chemother. Pharmacol 29:461–466

    CAS  Google Scholar 

  • Geary TG, Akood MA, Jensen JB (1983) Characteristics of chloroquine binding to glass and plastic. Am J Trop Med Hyg 32:19–23

    PubMed  CAS  Google Scholar 

  • Griffin JP D’Arcy PF 1988 Drug intera ctions in vitro. In: A manual of adverse drug interactions 4th edit. Wright, Bristol pp 6–16

    Google Scholar 

  • Gomez M, Alvarez A, Cid E (1993) Influence of cellulosic derivatives on in vitro stability and availability of diethylpropion in prescription orders. Rev Med Chile 121:1013–1016

    PubMed  CAS  Google Scholar 

  • Hansen HC, Spillum A (1991) Loss of nitroglycerin during passage through two different infusion sets. Acta Pharm Nord 3:131–136

    PubMed  CAS  Google Scholar 

  • Hendeles L Weinberger M Milavetz G Hill M Vaughan L 1985 Food-induced “dose-dumping” from a once-a-day theophylline product as a cause of theophylline toxicity. Chest 87:758–765

    Article  PubMed  CAS  Google Scholar 

  • Hendeles L, Breton AL, Beaty R, Harman E (1995) Therapeutic equivalence of a generic slow-release theophylline tablet. Pharmacotherapy 15:26–35

    PubMed  CAS  Google Scholar 

  • Hill JB (1959) Adsorption of insulin to glass. Proc Soc Exp Biol Med 102:75–77

    PubMed  CAS  Google Scholar 

  • Holmes SE, Aldous S (1991) Stability of miconazole in peritoneal dialysis fluid. Am J Hosp Pharm 48:286–290

    PubMed  CAS  Google Scholar 

  • Jenke DR (1993) Modelling of solute sorption by polyvinyl chloride plastic infusion bags. J Pharm Sei 82:1134–1139

    Article  CAS  Google Scholar 

  • Johnson BF, Fowle ASE, Lader S, Fox J, Munro-Faure AD (1973) Biological activity of digoxin from Lanoxin produced in the United Kingdom. Br Med J 4:323–326

    Article  PubMed  CAS  Google Scholar 

  • Kowaluk EA, Roberts MS, Blackburn HD, Polack AE (1981) Interactions between drugs and polyvinyl chloride infusion bags. Am J Hosp Pharm 38:1308–1314

    PubMed  CAS  Google Scholar 

  • Lee MG (1986) Reduced absorption of drugs onto polybutadiene administration sets. Am J Hosp Pharm 43:1945–1950

    PubMed  CAS  Google Scholar 

  • Li LC, Zhang H, Pecosky DA (1993) The effect of surfactant on drug-plastic sorption phenomenon in solution. J Pharm Pharmacol 45:748–749

    Article  PubMed  CAS  Google Scholar 

  • Loucas SP, Maager P, Mehl B, Loucas ER (1990) Effect of vehicle ionic strength on sorption of nitroglycerin to a polyvinyl chloride administration set. Am J Hosp Pharm 47:1559–1562

    PubMed  CAS  Google Scholar 

  • Lund W (ed) (1994) British pharmaceutical codex. Pharmaceutical Press, London, pp 311–322

    Google Scholar 

  • Lyons RW (1979) Orange contact lenses from rifampicin. N Engl J Med 300:372–373

    PubMed  CAS  Google Scholar 

  • Malick AW, Amann AH, Baaske DM, Stoll RG (1981) Loss of nitroglycerin from solutions to intravenous plastic containers: a theoretical treatment. J Pharm Sei 70:798–800

    Article  CAS  Google Scholar 

  • McElnay JC D’Arcy PF 1980 Sites and mechanisms of drug interactions. I. In vitro intestinal and metabolic reactions. Int J Pharm 5:167–185

    Article  CAS  Google Scholar 

  • McElnay JC, Nichol AC (1984) The comparison of a novel continuous flow dissolution apparatus for suppositories with the rotating basket technique. Int J Pharm 19:89–96

    Article  CAS  Google Scholar 

  • McElnay JC, Taggart AJ, Kerr B, Passmore P (1986) Comparison of serum indomethacin profiles after rectal administration of two brands of indomethacin suppositories in healthy volunteer subjects. Int J Pharm 33:195–199

    Article  CAS  Google Scholar 

  • McElnay JC, Elliott DS, DArcy PF (1987) Binding of human insulin to burette administration sets. Int J Pharm 36:199–203

    Article  CAS  Google Scholar 

  • McElnay JC, Elliott DS, Cartwright-Shamoon J, D’Arcy PF (1988) Stability of methotrexate and vinblastine in burette administration sets. Int J Pharm 47:239–247

    Article  Google Scholar 

  • McGinity JW, Lach JL (1976) In vitro adsorption of various pharmaceuticals to montmorillonite. J Pharm Sei 65:896–902

    Article  CAS  Google Scholar 

  • McMillan M (1989) Clinical pharmacokinetics of cyclosporin. Pharmacol Ther 42:135–156

    Article  PubMed  CAS  Google Scholar 

  • Moorhatch P, Chiou WL (1974) Interactions between drugs and plastic intravenous fluid bags. II. Leaching of chemicals from bags containing various solvent media. Am J Hosp Pharm 31:149–152

    PubMed  CAS  Google Scholar 

  • Morgan DJ, McCormick Y, Cosolo W, Roller L, Zalcberg J (1992) Prolonged release of morphine alkaloid from a lipophilic suppository base in vitro and in vivo. Int J Clin Pharmacol Ther 30:576–581

    CAS  Google Scholar 

  • Newerly K, Berson SA (1957) Lack of specificity of insulin 1–131 binding by isolated rat diaphragm. Proc Soc Exp Biol Med 94:751–755

    PubMed  CAS  Google Scholar 

  • Parker WA, McCara ME (1980) Compatibility of diazepam with intravenous fluid containers and administration sets. Am J Hosp Pharm 37:496–500

    PubMed  CAS  Google Scholar 

  • Pearson SD, Trissel LA (1993) Leaching of diethylhexyl phthalate from polyvinyl chloride containers by selected drugs and formulation components. Am J Hosp Pharm 50:1405–1409

    PubMed  CAS  Google Scholar 

  • Petty C, Cunningham NL (1974) Insulin adsorption by glass infusion bottles, polyvinyl chloride infusion containers and intravenous tubing. Anesthesiology 40:400–404

    Article  PubMed  CAS  Google Scholar 

  • Riley SA, Flegg PJ, Mandal BK (1986) Contact lens staining due to sulphasalazine. Lancet I:972

    Article  PubMed  CAS  Google Scholar 

  • Roberts MS, Kowaluk EA, Polack AE (1991) Prediction of solute sorption by polyvinyl chloride plastic infusion bags. J Pharm Sci 80:449–455

    Article  PubMed  CAS  Google Scholar 

  • Salomies HEM, Heinonen RM, Toppila MAI (1994) Sorptive loss of diazepam, nitroglycerin and warfarin sodium to polypropylene-lined infusion bags (Softbags). Int J Pharm 110:197–201

    Article  CAS  Google Scholar 

  • Sautou V, Chopineau I, Gremeau R, Chevrier R, Bruneaux F (1994) Compatibility with medical plastics and stability of continuously and simultaneously infused isosorbide dinitrate and heparin. Int J Pharm 107:111–119

    Article  CAS  Google Scholar 

  • Schildt B, Ahlgren T, Bergham L, Wendt Y (1978) Adsorption of insulin by infusion materials. Acta Anaesth Scand 22:556–562

    Article  PubMed  CAS  Google Scholar 

  • Shaw LM, Bowers LD, Demers L, Freeman DJ, Moyer T, Sarghvi A, Seltman H, Venkataramanan R (1987) Critical issues of cyclosporine monitoring: report of the Task Force on cyclosporine monitoring. Clin Chem 36:1841–1846

    Google Scholar 

  • Sugar J (1974) Adenochrome pigmentation of hydrophilic lenses. Arch Ophthalmol 91:11–12

    PubMed  CAS  Google Scholar 

  • Taormina D, Abdallah HY, Venkataramanan R, Logue L, Burckart GJ, Ptachcinski RJ, Todo S, Fung JJ, Starzl TE (1992) Stability and sorption of FK 506 in 5% dextrose and 0.9% sodium chloride injection in glass, polyvinyl chloride and polyolefin containers. Am J Hosp Pharm 49:119–122

    PubMed  CAS  Google Scholar 

  • Trissel LA, Xu Q, Kwan J, Martinez JF (1994) Compatibility of paclitaxel injection vehicle with intravenous administration and extension sets. Am J Hosp Pharm 51:2804–2810

    PubMed  CAS  Google Scholar 

  • Twardowski ZJ, Nolph KD, McGary TJ, Moore HL, Collin P, Ausman RK, Slimack WS (1983a) Insulin binding to plastic bags: a methodologic study. Am J Hosp Pharm 40:575–579

    PubMed  CAS  Google Scholar 

  • Twardowski ZJ, Nolph KD, McGary TJ, Moore HL (1983b) Nature of insulin binding to plastic bags. Am J Hosp Pharm 40:579–582

    PubMed  CAS  Google Scholar 

  • Twardowski ZJ, Nolph KD, McGary TJ, Moore HL (1983c) Influence of temperature and time on insulin adsorption to plastic bags. Am J Hosp Pharm 40:583–586

    PubMed  CAS  Google Scholar 

  • Tyrer JH, Eadie MJ, Sutherland JM, Hooper WD (1970) Outbreak of anticonvulsant intoxication in an Australian city. Br Med J 2:271–273

    Article  Google Scholar 

  • Venkataramanan R, Burckart GJ, Ptachcinski RJ, Blaha R, Logue LW, Bahnson A, Giam C-S, Brady JE (1986) Leaching of diethylhexyl phthalate from polyvinyl chloride bags into intravenous cyclosporine solution. Am J Hosp Pharm 43:2800–2802

    PubMed  CAS  Google Scholar 

  • Weinberger M, Hendeles L, Bighley L (1978) The relation of product formulation to absorption of oral theophylline. N Engl J Med 299:852–857

    Article  PubMed  CAS  Google Scholar 

  • Wideroe TE, Smeby LC, Berg KL, Jorstad S, Svartas TM (1983) Intraperitoneal (125I) insulin absorption during intermittent and continuous peritoneal dialysis. Kidney Int 23:22–28

    Article  PubMed  CAS  Google Scholar 

  • Yahya AM, McElnay JC, D’Arcy PF (1985) Binding of chloroquine to glass. Int J Pharm 25:217–223

    Article  CAS  Google Scholar 

  • Yahya AM, McElnay JC, D’Arcy PF (1986) Investigation of chloroquine binding to plastic materials. Int J Pharm 34:137–143

    Article  CAS  Google Scholar 

  • Yuen PH, Denman SL, Sokoloski TD, Burkman AM (1979) Loss of nitroglycerin from aqueous solution into plastic intravenous delivery systems. J Pharm Sci 68:1163–1166

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. J. C. McElnay
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  2. C. M. Hughes
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Editor information

Editors and Affiliations

  1. School of Pharmacy, The Queen’s University of Belfast, Medical Biology Centre, 97 Lisburn Road, BT9 7BL, Belfast, N. Ireland

    Patrick F. D’Arcy OBE, Ph.D., D.Sc.

  2. School of Pharmacy, The Queen’s University of Belfast, Medical Biology Centre, 97 Lisburn Road, BT9 7BL, Belfast, N. Ireland

    James C. McElnay Ph.D. (Director) (Director)

  3. Pharmacokinetics and Drug Metabolism, Parke-Davis Pharmaceutical Research, 2800 Plymouth Road, MI 48105, Ann Arbor, USA

    Peter G. Welling Ph.D., D.Sc. (Vice President) (Vice President)

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© 1996 Springer-Verlag Berlin Heidelberg

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McElnay, J.C., Hughes, C.M. (1996). In Vitro Drug Interactions. In: D’Arcy, P.F., McElnay, J.C., Welling, P.G. (eds) Mechanisms of Drug Interactions. Handbook of Experimental Pharmacology, vol 122. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61015-8_9

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  • DOI: https://doi.org/10.1007/978-3-642-61015-8_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64658-4

  • Online ISBN: 978-3-642-61015-8

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