Fatty Liver and Drugs

  • M. U. Dianzani
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 121)


Fatty infiltration of the liver is one of the most common responses of the liver to injury. The mechanisms, however, can differ according to the type of injury. To gain a good understanding of these mechanisms, the general scheme of triglyceride metabolism in the liver must be considered. Triglycerides (TGs), which are present in the hepatocytes, are synthesized locally from glycerol and fatty acids by TG synthetase. The liver uses TGs either to incorporate them in membranes, or to incorporate them in lipoproteins, which are “secreted” in the blood, or also, in restricted amounts, to hydrolyze them, usually within secondary lysosomes. The amount of TGs present inside a single hepatocyte therefore represents the balance between synthetic processes and removal.


Lipid Peroxidation Fatty Liver Carbon Tetrachloride Covalent Binding Smooth Endoplasmic Reticulum 
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© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • M. U. Dianzani

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