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Drug-Induced Hepatotoxicity pp 25–42Cite as

Clinical Studies and Role of Necrosis in Hepatotoxicity

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 121))

Abstract

Zonal hepatocellular necrosis, which is a response to chemicals including drugs and a phenomenon often seen in clinical pathology and the laboratory, is the subject of this short treatise. The critical analysis of the liver biopsies of over 40 patients with acetaminophen overdose has served as the basis of specific hypotheses concerning the responses of the liver to certain forms of injury namely: (1) zone 3 (perivenous) hepatocytes die as a unit, and this phenomenon is physiologic or adaptive: and (2) recovery is also a coordinated response involving removal of the dead hepatocytes (and toxic metabolites) and regeneration of new hepatocytes to reconstitute this zone 3 unit.Several important observations are also made concerning the profound negative effects of co-existing ethanol toxicity on the extent of hepatic necrosis and course of recovery in 20 patients with acetaminophen plus ethanol overdose. It was found that exposure to alcohol led to an extension of hepatocellular necrosis beyond the zone 3 unit, and that there was a delay of regeneration and recovery.

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Authors
  1. R. G. Cameron
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  2. L. M. Blendis
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Editor information

Editors and Affiliations

  1. Department of Pathology Division of Experimental Pathology, University of Toronto, Medical Sciences Building, 1 King’s College Circle, M5S 1A8, Toronto, Ontario, Canada

    Ross G. Cameron M.D., Ph.D.

  2. Department of Clinical Biochemistry Banting Institute, University of Toronto, Room 521, 100 College Street, M5G 1L5, Toronto, Ontario, Canada

    George Feuer Ph.D.

  3. Parke-Davis Pharmaceutical Research Division Department of Pathology and Experimental Toxicology, Warner Lambert Company, 2800 Plymouth Road, 48105, Ann Arbor, MI, USA

    Felix A. de la Iglesia M.D.

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© 1996 Springer-Verlag Berlin Heidelberg

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Cameron, R.G., Blendis, L.M. (1996). Clinical Studies and Role of Necrosis in Hepatotoxicity. In: Cameron, R.G., Feuer, G., de la Iglesia, F.A. (eds) Drug-Induced Hepatotoxicity. Handbook of Experimental Pharmacology, vol 121. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61013-4_2

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  • DOI: https://doi.org/10.1007/978-3-642-61013-4_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64657-7

  • Online ISBN: 978-3-642-61013-4

  • eBook Packages: Springer Book Archive

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