Abstract
Numerous studies (see Levin et al. 1989b, for a review) have demonstrated that schizophrenia is often associated with deficits on a range of cognitive abilities including, but not limited to, attentional, memory, and executive cognitive functions. These deficits may have a profound impact on a schizophrenic individual - for some individuals they may, in fact, be more disabling than hallucinations or delusions. The cognitive impairments related to schizophrenia are present at the onset of the disorder (Hoff et al. 1992a; Saykin et al. 1994) and may vary in severity independently of psychotic features of the illness such as hallucinations and delusions (Faustman et al. 1988). Cognitive deficits in schizophrenia relate to the quality of life (e.g., interpersonal relationships, vocational functioning) in individuals with the disorder (Wagman et al. 1987). The exact reasons for cognitive dysfunction in schizophrenia are likely to be complex and may include both core structural pathology and neurochemical dysregulation.
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Faustman, W.O., Hoff, A.L. (1996). Effects of Antipsychotic Drugs on Neuropsychological Measures. In: Csernansky, J.G. (eds) Antipsychotics. Handbook of Experimental Pharmacology, vol 120. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61007-3_15
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