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Effects of Antipsychotic Drugs on Neuropsychological Measures

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Book cover Antipsychotics

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 120))

Abstract

Numerous studies (see Levin et al. 1989b, for a review) have demonstrated that schizophrenia is often associated with deficits on a range of cognitive abilities including, but not limited to, attentional, memory, and executive cognitive functions. These deficits may have a profound impact on a schizophrenic individual - for some individuals they may, in fact, be more disabling than hallucinations or delusions. The cognitive impairments related to schizophrenia are present at the onset of the disorder (Hoff et al. 1992a; Saykin et al. 1994) and may vary in severity independently of psychotic features of the illness such as hallucinations and delusions (Faustman et al. 1988). Cognitive deficits in schizophrenia relate to the quality of life (e.g., interpersonal relationships, vocational functioning) in individuals with the disorder (Wagman et al. 1987). The exact reasons for cognitive dysfunction in schizophrenia are likely to be complex and may include both core structural pathology and neurochemical dysregulation.

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References

  • Andreasen N, Olsen S (1982) Negative vs. positive schizophrenia: definition and reliability. Arch Gen Psychiatry 39:789–794

    PubMed  CAS  Google Scholar 

  • Angrist B, van Kämmen DP (1984) CNS stimulants as tools in the study of schizophrenia. Trends Neurosci 7:388–390

    Article  Google Scholar 

  • Atkinson R, Shiffrin R (1968) A proposed system and its control processes. In: Spence K, Spence J (eds) Advances in the psychology of learning and motivation. Academic, New York

    Google Scholar 

  • Bigler ED (1987) The clinical significance of cortical atrophy and ventricular enlargement in schizophrenia. Arch Clin Neuropsychology 2:385–392

    CAS  Google Scholar 

  • Bilder RM, Lieberman JA, Kim Y, Alvir JM, Reiter G (1992a) Methylphenidate and neuroleptic effects on oral word production in schizophrenia. Neuropsychiatry Neuropsychol Behav Neurol 5:262–271

    Google Scholar 

  • Bilder RM, Türkei E, Lipschutz-Broch L, Lieberman JA (1992b) Antipsychotic medication effects on neuropsychological functions. Psychopharmacol Bull 28:353–366

    PubMed  CAS  Google Scholar 

  • Bogerts B, Meertz E, Schönfeldt-Bausch R (1985) Basal ganglia and limbic system pathology in schizophrenia. Arch Gen Psychiatry 42:784–791

    PubMed  CAS  Google Scholar 

  • Braff DL, Saccuzzo DP (1982) Effect of antipsychotic medication on speed of information processing in schizophrenic patients. Am J Psychiatry 139:1127–1130

    PubMed  CAS  Google Scholar 

  • Braff DL, Heaton R, Kuck J, Cullum M, Moranville J, Grant I, Zisook S (1991) The generalized pattern of neuropsychological deficits in outpatients with chronic schizophrenia with heterogeneous Wisconsin Card Sorting test results. Arch Gen Psychiatry 48:891–898

    PubMed  CAS  Google Scholar 

  • Broadbent D (1959) Perception and communication. Pergamon, London

    Google Scholar 

  • Calev A (1984) Recall and recognition in mildly disturbed schizophrenics: the use of matched tasks. Psychol Med 14:425–429

    Article  PubMed  CAS  Google Scholar 

  • Calev A, Berlin H, Lerer B (1987) Remote and recent memory in long-hospitalized chronic schizophrenics. Biol Psychiatry 22:79–85

    Article  PubMed  CAS  Google Scholar 

  • Caligiuri MP, Lohr JB, Jeste DV (1993) Parkinsonism in neuroleptic-naive schizophrenic patients. Am J Psychiatry 150:1343–1348

    PubMed  CAS  Google Scholar 

  • Cassens G, Inglis AK, Appelbaum PS, Gutheil TG (1990) Neuroleptics: effects on neuropsychological function in chronic schizophrenic patients. Schizophr Bull 16:477–499

    PubMed  CAS  Google Scholar 

  • Chapman LJ, Chapman JP (1973) Disordered thought in schizophrenia. Prentice-Hall, Englewood Cliffs

    Google Scholar 

  • Conrad AJ, Abebe T, Austin R, Forsythe S, Scheibel AB (1991) Hippocampal pyramidal cell disarray in schizophrenia as a bilateral phenomenon. Arch Gen Psychiatry 45:413–417

    Google Scholar 

  • Cooper JA, Sagar HJ, Doherty SM, Jordan N, Tidswell P, Sullivan EV (1992) Different effects of dopaminergic and anticholinergic therapies on cognitive and motor function in Parkinson‚s disease. A follow-up study of untreated patients. Brain 115:1701–1725

    Article  PubMed  Google Scholar 

  • Craft S, Yurgelin-Todd D, Kaplan E, Aizley H, Levin S (1988) Concurrent deficits of frontal and spatial tasks in schizophrenics without affective symptoms. J Clin Exp Neuropsychol 10:71

    Google Scholar 

  • Crow TJ (1980) Molecular pathology in schizophrenia: more than one disease process? Br Med J 280:66–68

    Article  PubMed  CAS  Google Scholar 

  • Crow TJ, Done DJ (1992) Prenatal exposure to influenza does not cause schizophrenia. Br J Psychiatry 161:390–393

    Article  PubMed  CAS  Google Scholar 

  • Csernansky JG, Murphy GM, Faustman WO (1991) Limbic/Mesolimbic connections and the pathogenesis of schizophrenia. Biol Psychiatry 30:383–400

    Article  PubMed  CAS  Google Scholar 

  • Daniel DG (1994) Comparison of risperidone and clozapine on clinical and cognitive functions in psychotic disorders. Biol Psychiatry 35:667[abstract]

    Article  Google Scholar 

  • Danion J-M, Peretti S, Grange D, Bilik M, Imbs J-L, Singer L (1992) Effects of chlorpromazine and lorazepam on explicit memory, repetition priming and cognitive skill learning in healthy volunteers. Psychopharmacology 108:345–351

    Article  PubMed  CAS  Google Scholar 

  • Daston PG (1959) Effects of two phenothiazine drugs on concentrative attention span of chronic schizophrenics. J Clin Psychol 15:106–109

    Article  PubMed  CAS  Google Scholar 

  • DeLisi LE, Stritzke P, Riordan H, Holan V, Boccio A, Kushner M, McClelland J, Van Eyl O, Anand A (1992) The timing of brain morphological changes in schizophrenia and their relationship to clinical outcome. Biol Psychiatry 31:241–25

    Article  PubMed  CAS  Google Scholar 

  • DeLisi LE, Tew W, Xie S-h, Hoff AL, Sakuma M, Kushner M, Lee G, Shedlack K, Smith AM, Grimson R (1995) A prospective follow-up study of brain morphology and cognition in first-episode schizophrenic patients: Preliminary finding. Biol Psychiatry 38:349–360

    Article  PubMed  CAS  Google Scholar 

  • DiMascio A, Havens L, Klerman GL (1963) The psychopharmacology of phenothiazine compounds: A comparative study of the effects of chlopromazine, promethazine, trifluoperazine, and perphenazine in normal males. II. Results and discussion. J Nerv Ment Dis 136:15–28

    Article  PubMed  CAS  Google Scholar 

  • Earle-Boyer EA, Serper MR, Davidson M, Harvey PD (1991) Continuous performance tests in schizophrenic patients: stimulus and medication effects on performance. Psychiatr Res 37:47–56

    Article  CAS  Google Scholar 

  • Eaton EM, Busk J, Maloney MP, Sloane RB, Whipple K, White K (1979) Hemispheric dysfunction in schizophrenia: assessment by visual perception tasks. Psychiatr Res 1:325–332

    Article  CAS  Google Scholar 

  • Eitan N, Levin Y, Ben-Artzi E, Levy A, Neumann M (1992) Effects of antipsychotic drugs on memory functions of schizophrenic patients. Acta Psychiatr Scand 85:74- 76

    Article  PubMed  CAS  Google Scholar 

  • Fahn S (1992) Parkinson‚s disease and other basal ganglion disorders. In: Asbury AK, McKhann GM, McDonald WI (eds) Diseases of the nervous system: clinical neurobiology, 2nd edn. Saunders, Philadelphia, p 1144

    Google Scholar 

  • Faustman WO, Fowler SC (1982) An examination of methodological refinements, clozapine and fluphenazine in the anhedonia paradigm. Pharmacol Biochem Behav 17:987–993

    Article  PubMed  CAS  Google Scholar 

  • Faustman WO, Moses JA Jr, Csernansky JG (1988) Luria-Nebraska performance and symptomatology in unmedicated schizophrenic patients. Psychiatry Res 26:29–34

    Article  PubMed  CAS  Google Scholar 

  • Fay en M, Goldman MB, Moulthrop MA, Luchins DJ (1988) Differential memory impairment with dopaminergic versus anticholinergic treatment of drug-induced extrapyramidal symptoms. Am J Psychiatry 145:483–486

    PubMed  CAS  Google Scholar 

  • Flicker C, Serby M, Ferris SH (1990) Scopolamine effects on memory, language visuospatial praxis and psychomotor speed. Psychopharmacology 100:243–250

    Article  PubMed  CAS  Google Scholar 

  • Fredericks RS, Finkel P (1978) Schizophrenic performance on the Halstead-Reitan Battery. J Clin Psychol 34:26–30

    Article  PubMed  CAS  Google Scholar 

  • Gold JM, Hurt SW (1990) The effects of haloperidol on thought disorder and IQ in schizophrenia. J Pers Assess 54:390–400

    Article  PubMed  CAS  Google Scholar 

  • Gold JM, Randolph C, Carpenter CJ, Goldberg TE, Weinberger DR (1992) the performance of patients with schizophrenia on the Wechsler Memory Scale-Revised. The Clinical Neuropsychologist 6:367–373

    Article  Google Scholar 

  • Gold JM, Randolph C, Carpenter CJ, Goldberg TE, Weinberger DR (1992) Forms of memory failure in schizophrenia. J Abn Psychology 101:487–494

    Article  CAS  Google Scholar 

  • Goldberg TE, Weinberger DR (1988) Probing prefrontal function in schizophrenia with neuropsychological paradigms. Schizophr Bull 14:179–183

    PubMed  CAS  Google Scholar 

  • Goldberg TE, Ragland JD, Torrey EF, Gold JM, Bigelow LB, Weinberger DR (1990) Neuropsychological assessment of monozygotic twins discordent for schizophrenia. Arch Gen Psychiatry 47:1066–1072

    PubMed  CAS  Google Scholar 

  • Goldberg TE, Bigelow LB, Weinberger DR, Daniel DG, Kleinman JE (1991) Cognitive and behavioral effects of the coadministration of dextroamphetamine and haloperidol in schizophrenia. Am J Psychiatry 148:78–84

    PubMed  CAS  Google Scholar 

  • Goldberg TE, Greenberg RD, Griffin SJ, Gold JM, Kleinman JE, Pickar D, Schultz SC, Weinberger DR (1993) The effect of clozapine on cognition and psychiatric symptoms in patients with schizophrenia. Br J Psychiatry 162:43–48

    Article  PubMed  CAS  Google Scholar 

  • Goldberg TE, Weinberger DR (1994) The effects of clozapine on neurocognition An overview J Clin Psychiatry 55 [Suppl B]:88–90

    Google Scholar 

  • Goldstein K (1959) Functional disturbances in brain damage. In: Arieti S (ed) American handbook of psychiatry. Basic Books, New York

    Google Scholar 

  • Goode DJ, Manning AA, Middleton JF, Williams B (1981) Fine motor performance before and after treatment in schizophrenic and schizoaffective patients. Psychiatry Res 5:247–255

    Article  PubMed  CAS  Google Scholar 

  • Hagger C, Buckley P, Kenny JT, Friedman L, Ubogy D, Meltzer HY (1993) Improvement in cognitive functions and psychiatric symptoms in treatment-refractory schizophrenic patients receiving clozapine. Biol Psychiatry 34:702–712

    Article  PubMed  CAS  Google Scholar 

  • Harvey PD, Pedley M (1989) Auditory and visual distractability in schizophrenia: clinical and medication status correlations. Schizophr Res 2:295–300

    Article  PubMed  CAS  Google Scholar 

  • Heaton R, Badde L, Johnson K (1978) Neuropsychological test results associated with psychiatric disorders in adults. Psychol Bull 85:141–162

    Article  PubMed  CAS  Google Scholar 

  • Heaton RK, Crowley TJ (1981) Effects of psychiatric disorders and their somatic treatments on neuropsychological test results. In: Filskov SB, Boll TJ (eds) Handbook of clinical neuropsychology. Wiley, New York

    Google Scholar 

  • Heaton R, Drexler M (1987) Clinical neuropsychological findings in schizophrenia and aging. In: Miller N, Cohen G (eds) Schizophrenia and aging. Guilford Press, New York

    Google Scholar 

  • Heilizer F (1959) The effects of chlorpromazine upon psychomotor and psychiatric behavior of chronic schizophrenic patients. J Nerv Ment Dis 128:358–364

    PubMed  CAS  Google Scholar 

  • Hitri A, Craft RB, Fallon J, Sethi R, Sinha D (1987) Serum neuroleptic and anticholinergic activity in relationship to cognitive toxicity of antiparkinsonian agents in schizophrenic patients. Psychopharmacol Bull 23:33–37

    PubMed  CAS  Google Scholar 

  • Hoff AL, Riordan H, O‚Donnell DW, Morris L, DeLisi LE (1992a) Neuropsychological functioning of first-episode schizophreniform patients. Am J Psychiatry 149:898–903

    PubMed  CAS  Google Scholar 

  • Hoff AL, Riordan H, O‚Donnell D, Stritzke P, Neale C, Boccio A, Anand AK, Delisi LE (1992) Anomalous lateral sulcus asymmetry and cognitive function in first- episode schizophrenia. Schizophr Bull 18:257–272

    PubMed  CAS  Google Scholar 

  • Wieneke M, DeVilliers D, Espinoza S, Gustafson M, Mone R (1993) Effects of clozapine on cognitive function. Presented at the annual meeting of the Amer Psychiatric Assoc, San Francisco

    Google Scholar 

  • Hollister LE, Csernansky JG (1990) Clinical pharmacology of psychotherapeutic drugs, 3rd edn. Churchill Livingstone, New York

    Google Scholar 

  • Janowsky DS, Huey L, Storms L, Judd LL (1977) Methylphenidate hydrochloride effects on psychological tests in acute schizophrenic and nonpsychotic patients. Arch Gen Psychiatry 34:189–194

    PubMed  CAS  Google Scholar 

  • Judson AJ, MacCasland BW (1960) The effects of chlorpromazine on psychological test scores. J Consult Psychology 24:192

    Article  Google Scholar 

  • Kahneman D (1973) Attention and effort. Prentice-Hall, Englewood Cliffs

    Google Scholar 

  • Killian GA, Holzman PS, Davis JM, Gibbons R (1984) Effects of psychotropic medication on selected cognitive perceptual measures. J Abn Psychology 93:58–70

    Article  CAS  Google Scholar 

  • King DJ (1990) The effect of neuroleptics on cognitive and psychomotor function. Br J Psychiatry 157:799–811

    Article  PubMed  CAS  Google Scholar 

  • King DJ, Henry G (1992) The effect of neuroleptics on cognitive and psychomotor function: a preliminary study in healthy volunteers. Br J Psychiatry 160:647- 653

    Article  PubMed  CAS  Google Scholar 

  • Klorman R, Bauer LO, Coons HW, Lewis JL, Peloquin LJ, Perlmutter RA, Ryan RM, Salzman LF, Strauss J (1984) Enhancing effects of methylphenidate on normal young adults cognitive processes. Psychopharmacol Bull 20:3–9

    PubMed  CAS  Google Scholar 

  • Koh S (1978) Remembering of verbal materials by schizophrenic adults. In: Schwartz S (ed) Language and cognition in schizophrenia. Erlbaum, Hillsdale, NJ, pp 59–99

    Google Scholar 

  • Kolb B, Whishaw I (1983) Performance of schizophrenic patients on tests sensitive to left or right frontal, temporal, or parietal function in neurological patients. J Nerv Ment Dis 171:435–443

    Article  PubMed  CAS  Google Scholar 

  • Kornetsky C, Humphries O, Evarts Ev (1957) Comparison of psychological effects of certain centrally acting drugs in man. A.M.A. Arch Neurol Psychiatr 77:318–324

    CAS  Google Scholar 

  • Kornetsky C, Pettit M, Wynne R, Evarts EV (1959) A comparison of the psychological effects of acute and chronic administration of chlorpromazine and secobarbitol in schizophrenic patients. J Mental Science 105:190–198

    CAS  Google Scholar 

  • Kornetsky C, Mirsky AF (1966) On certain psychopharmacological and physiological differences between schizophrenics and normals. Psychopharmacologia 8:309–318

    Article  PubMed  CAS  Google Scholar 

  • Kraepelin E (1913) Dementia praecox and paraphrenia. Livingston, Edinburgh.

    Google Scholar 

  • Lee MA, Thompson PA, Meltzer HY (1994) Effects of clozapine on cognitive function in schizophrenia. J Clin Psychiatry 55 [Suppl B]:82—87

    PubMed  Google Scholar 

  • Levin BE, Liabre MM, Weiner WJ (1989a) Cognitive impairments associated with early Parkinson‚s disease. Neurology 39:557–561

    PubMed  CAS  Google Scholar 

  • Levin S, Yurgelun-Todd D, Craft S (1989b) Contributions of clinical neuropsyhology to the study of schizophrenia. J Abnorm Psychol 98:341–356

    Article  PubMed  CAS  Google Scholar 

  • Lieberman JA, Koreen AR (1993) Neurochemistry and neuroendocrinology of schizophrenia. Schizophr Bull 19:371–430

    PubMed  CAS  Google Scholar 

  • Magliozzi JR, Mungas D, Laubly JN, Blunden D (1989) Effect of haloperidol on a symbol digit substitution task in normal adult males. Neuropsychopharmacology 2:29–37

    Article  PubMed  CAS  Google Scholar 

  • Marder SR, Asarnow RF, Van Putten T (1984) Information processing and neuroleptic response in acute and stabilized schizophrenic patients. Psychiatry Res 13:41- 49

    Article  PubMed  CAS  Google Scholar 

  • Mattila MJ, Mattila ME (1990) Effects of remoxipride on psychomotor performance, alone and in combination with ethanol and diazepam. Acta Psychiatr Scand 82 [Suppl. 358]: 54–55

    Article  Google Scholar 

  • McGurk SR, Levin ED, Butcher LL (1992) Dopaminergic drugs reverse the impairment of radialarm maze performance caused by lesions involving the cholinergic medial pathway. Neuroscience 50:129–135

    Article  PubMed  CAS  Google Scholar 

  • Medalia A, Gold J, Merriam A (1988) The effects of neuroleptics on neuropsychological test results of schizophrenics Arch Clinical Neuropsychology 3:249–271

    CAS  Google Scholar 

  • Mednick SA, Machon RA, Huttunen MO, Bonett D (1988) Adult schizophrenia following prenatal exposure to an influenza epidemic. Arch Gen Psychiatry 45:189- 192

    PubMed  CAS  Google Scholar 

  • Meltzer HY, Matsubara S, Lee J-C (1989) The ratios of serotonin2and dopamine2affinities differentiate atypical and typical antipsychotic drugs. Psychopharmacol Bull 25:390–392

    PubMed  CAS  Google Scholar 

  • Miller LS, Faustman WO, Moses JA Jr (1993) Effect of medication status on neuropsychological performance in schizophrenic patients. Arch Clin Neuropsychol 8:250–251 [abstract]

    Google Scholar 

  • Molchan SE, Martinez RA, Hill JL, Weingartner HJ, Thompson K, Vitiello B, Sunderland T (1992) Increased cognitive sensitivity to scopolamine with age and a perspective on the scopolamine model. Brain Res Brain Res Rev 17:215–226

    Article  PubMed  CAS  Google Scholar 

  • Morice R, Ingram J (1983) Language complexity and age of onset of schizophrenia. Psychiatry Res 9:233–242

    Article  PubMed  CAS  Google Scholar 

  • Moses JA Jr (1984) The effect of presence or absence of neuroleptic medication treatment on Luria-Nebraska neuropsychological battery performance in a schizophrenic population. Int J Clin Neuropsychology 6:249–251

    Google Scholar 

  • Moses J A Jr, Maruish ME (1988) A critical review of the Luria-Nebraska neuropsychological battery literature: IV. Cognitive deficit in schizophrenia and related disorders. Int J Clin Neuropsychol 10:51–62

    Google Scholar 

  • Nakra BR, Margolis RB, Gfeller JD, Grossberg GT, Sata LS (1992) The effect of a single low dose of trihexyphenidyl on memory functioning in the healthy elderly. Int Psychoger 4:207–214

    Article  CAS  Google Scholar 

  • Nickols JE (1958) A controlled exploratory investigation into the effects of thorazine upon mental test scores of chronic hospitalized schizophrenics. The Psychological Record 8:67–76

    Google Scholar 

  • Nuechterlein K, Dawson M (1984) Information processing and attentional functioning in the developmental course of schizophrenic disorders. Schiz Bull 10:160–203

    CAS  Google Scholar 

  • Obiols JE, Marcos T, Salamero M (1987) Ventricular enlargement and neuropsychological testing in schizophrenia. Acta Psychiatr Scand 76:199–202

    Article  PubMed  CAS  Google Scholar 

  • Oltmanns TF, Ohayon J, Neale JM (1978) The effect of anti-psychotic medication and diagnostic criteria on distractibility in schizophrenia. J Psychiat Res 14:81–91

    Article  PubMed  CAS  Google Scholar 

  • Pearl D (1962) Phenothiazine effects in chronic schizophrenia. J Clin Psychology 18:86–89

    Article  CAS  Google Scholar 

  • Perlick D, Stastny P, Katz I, Mayer M, Mattis S (1986) Memory deficits and anticholinergic levels in chronic schizophrenia. Am J Psychiatry 143:230–232

    PubMed  CAS  Google Scholar 

  • Pfefferbaum A, Zipursky R, Lim KO, Zatz LM, Stah; SM, Jernigan TL (1988) Computed tomograpic evidence for generalized sulcal and ventricular enlargement in schizophrenia. Arch Gen Psychiatry 45:633–40

    CAS  Google Scholar 

  • Pugh LA (1968) Response time and electrodermal measures in chronic schizophrenia: the effects of chlorpromazine. J Nerv Ment Dis 146:62–70

    Article  PubMed  CAS  Google Scholar 

  • Pycock CJ, Kerwin RW, Carter CJ (1980) Effect of lesion of cortical dopamine terminals on subcortical dopamine in rats. Nature 286:74–77

    Article  PubMed  CAS  Google Scholar 

  • Richardson JS, Keegan DL, Bowen RC, Blackshaw SL, Cebrian-Perez S, Dayal N, Saleh S, Shrikhande S (1994) Verbal learning by major depressive disorder patients during treatment with fluoxetine or amitriptyline. Int Clin Psychopharma- cology 9:35–40

    Article  CAS  Google Scholar 

  • Roberts GW (1990) Schizophrenia: the cellular biology of a functional psychosis. Trends Neurosci 13:207–211

    CAS  Google Scholar 

  • Rosofsky I, Levin S, Holtzman P (1982) Psychomotility in the functional psychoses. J Abnorm Psychol 91:71–74

    CAS  Google Scholar 

  • Sala M, Braida D, Calcaterra P, Leone MP, Comotti FA, Gianola S, Gori E (1991) Effect of centrally administered atropine and pirenzepine on radial arm maze performance in the rat. Eur J Pharmacol 194:45–49

    Article  PubMed  CAS  Google Scholar 

  • Saykin A, Gur RC, Gur RE, Mozley D, Mozley L, Resnick SM, Kester B, Stafiniak P (1991) Neuropsychological function in schizophrenia: selective impairment in memory and learning. Arch Gen Psychiatry 48:618–624

    PubMed  CAS  Google Scholar 

  • Saykin AJ, Shtasel DL, Gur RE, Kester DB, Mozley LH, Stafiniak P, Gur RC (1994) Neuropsychological deficits in neuroleptic-native patients with first-episode schizophrenia. Arch Gen Psychiatry 51:124–131

    PubMed  CAS  Google Scholar 

  • Schultz SC, Koller MM, Kishore PR, Hamer RM, Gehl JJ, Friedel RO (1983) Ventricular enlargement in teenage patients with schizophrenia spectrum disorder. Am J Psychiatry 140:1592–1595

    Google Scholar 

  • Seidman L (1983) Schizophrenia and brain dysfunction: an integration of recent neurodiagnostic findings. Psychol Bull 94:195–238

    Article  PubMed  CAS  Google Scholar 

  • Seidman LJ, Pepple JR, Faraone SV, Kremen WS, Green AI, Brown WA, Tsuang MT (1993) Neuropsychological performance in chronic schizophrenia in response to neuroleptic dose reduction. Biol Psychiatry 33:575–584

    Article  PubMed  CAS  Google Scholar 

  • Shakow D (1962) Segmental set: a theory of formal psychological deficit in schizophrenia. Arch Gen Psychiatry 6:1–17 Shatin L, Rockmore L, Funk IC (1956) Response of psychiatric patients to massive doses of thorzine: II. Psychological test performance and comparative drug evaluation. Psychiatr Q 30:402–416

    Google Scholar 

  • Smet IC, Goldman RS, Red Cloud S, Gupta P, Kilaru S, Tandon R, Berent S (1994) Neuropsychological performance in schizophrenic inpatients as a function of medication status. Biol Psychiatry 35:666[Abstract]

    Article  Google Scholar 

  • Spiegel DE, Keith-Spiegel P (1967) The effects of carphenazine, trifluoperazine, and chlorpromazine on ward behavior, physiological functioning and psychological test scores in chronic schizophrenic patients. J Nerv Ment Dis 144:111–116

    Article  PubMed  CAS  Google Scholar 

  • Spohn HE, Lacoursiere RB, Thompson K, Coyne L (1977) Phenothiazine effects on psychological and psychophysiological dysfunction in chronic schizophrenics. Arch Gen Psychiatry 34:633–644

    PubMed  CAS  Google Scholar 

  • Spohn Re, Coyne L, Lacoursiere R, Mazur D, Hayes K (1985) Relation of neuroleptic dose and tardive dyskinesia to attention, information-processing, and psycho- physiology in medicated schizophrenics. Arch Gen Psychiatry 42:849–859

    PubMed  CAS  Google Scholar 

  • Spohn HE, Strauss ME (1989) Relation of neuroleptic and anticholinergic medication to cognitive functions in schizophrenia. J Abnorm Psychol 98:367–380

    Article  PubMed  CAS  Google Scholar 

  • Stern RG, Kahn RS, Davidson M (1993a) Predictors of response to neuroleptic treatment in schizophrenia. Psychiatr Clin North Am 16:313–338

    PubMed  CAS  Google Scholar 

  • Stern Y, Richards M, Sano M, Mayeux (1993b) Comparison of cognitive changes in patients with Alzheimer‚s and Parkinson‚s disease. Arch Neurol 50:1040–1045

    PubMed  CAS  Google Scholar 

  • Strauss ME, Lew MF, Coyle JT, Tune LE (1985) Psychopharmacologic and clinical correlates of attenion in chronic schizophrenia. Am J Psychiatry 142:497–499

    PubMed  CAS  Google Scholar 

  • Strauss ME, Reynolds KS, Jayaram G, Tune LE (1990) Effects of anticholinergic medication on memory in schizophrenia. Schizophr Res 3:127–129

    Article  PubMed  CAS  Google Scholar 

  • Strauss WH, Klieser E (1990) Cognitive disturbances in neuroleptic therapy. Acta Psychiatr Scand 82 [Suppl 358]:56–57

    Article  Google Scholar 

  • Stuss DT, Benson DK (1984) Neuropsychological studies of the frontal lobes. Psychol Bull 95:3–28

    Article  PubMed  CAS  Google Scholar 

  • Sullivan EV, Sagar HJ, Gabrieli JDE, Corkin S, Growdon JH (1989) Different cognitive profiles on standard behavioral tests in Parkinson‚s disease and Alzheimer‚s disease. J Clin Exper Neuropsychol 11:799–820

    Article  CAS  Google Scholar 

  • Sweeney JA, Keilp JG, Haas GL, Hill J, Weiden PJ (1991) Relationships between medication treatments and neuropsychological test performance in schizophrenia. Psychiatr Res 37:297–308

    Article  CAS  Google Scholar 

  • Syndulko K, Gilden ER, Hansch EC, Potvin AR, Tourtellotte WW, Potvin JH (1981) Decreased verbal memory associated with anticholinergic treatment in Parkinson‚s disease patients. Int J Neurosci 14:61–66

    Article  PubMed  CAS  Google Scholar 

  • Takei N, Sham P, O‚callaghan E, Murray GK, Glover G, Murray RM (1994) Prenatal exposure to influenze and the development of schizophrenia: is the effect confined to females? Am J Psychiatry 151:117–119

    PubMed  CAS  Google Scholar 

  • Tamlyn D, McKenna PJ, Mortimer AM, Lund CE, Hammond S, Baddeley AD (1992) Memory impairment in schizophrenia: its extent, affiliations and neuropsychological character. Psychol Med 22:101–115

    Article  PubMed  CAS  Google Scholar 

  • Taylor M, Abrams R (1984) Cognitive impairment in schizophrenia. Am J Psychiatry 141:196–201

    PubMed  CAS  Google Scholar 

  • Tomer R (1989) Asymmetrical effects of neuroleptics on psychotic patients‚ performance on a tactile discrimination task. J Nerv Ment Dis 177:699–700

    Article  PubMed  CAS  Google Scholar 

  • Tomer R, Flor-Henry P (1989) Neuroleptics reverse attention asymmetries in schizophrenic patients. Biol Psychiatry 25:852–860

    Article  PubMed  CAS  Google Scholar 

  • Tomer R (1990) Neuroleptic effects on interhemispheric and intrahemispheric performance of tactile discrimination tasks by schizophrenic patients. Psychiatry Res 32:289–296

    Article  PubMed  CAS  Google Scholar 

  • Tsuang MT, Gilbertson MW, Faraone SV (1991) The genetics of schizophrenia: current knowledge and future directions. Schizophr Res 4:157–171

    Article  PubMed  CAS  Google Scholar 

  • Tune LE, Strauss ME, Lew MF, Breitlinger E, Coyle JT (1982) Serum levels of anticholinergic drugs and impaired recent memory in chronic schizophrenic patients. Am J Psychiatry 139:1460–1462

    PubMed  CAS  Google Scholar 

  • van Herwaarden G, Berger HJ, Horstink MW (1993) Short-term memory in Parkinson‚s disease after withdrawal of long-term anticholinergic therapy. Clin Neuropharmacology 16:438–443

    Article  Google Scholar 

  • van Spaendonck KPM, Berger HJC, Horstink MWI, Buytenhuijs EL, Cools AR (1993) Impaired cognitive shifting in parkinsonian patients on anticholinergic therapy. Neuropsychologia 31:407–411

    Article  PubMed  Google Scholar 

  • Wagman AMI, Heinrichs DW, Carpenter WT Jr. (1987) Deficit and nondeficit forms of schizophrenia: neuropsychological evaluation. Psychiatr Res 22:319–330

    Article  CAS  Google Scholar 

  • Wahba M, Donlon PT, Meadow A (1981) Cognitive changes in acute schizophrenia with brief neuroleptic treatment. Am J Psychiatry 138:1307–1310

    PubMed  CAS  Google Scholar 

  • Weinberger DR, DeLisi LE, Perman GP, Targum S, Wyatt RJ (1982) Computed tomography in schizophreniform disorder and other acute psychiatric disorders. Arch Gen Psychiatry 39:778–783

    PubMed  CAS  Google Scholar 

  • Weinberger DR, Berman K, Zee R (1986) Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia: I. Regional cerebral blood flow (rCBF) evidence. Arch Gen Psychiatry 43:114–125

    PubMed  CAS  Google Scholar 

  • Weinberger DR, Berman KF, Suddath R, Torrey EF (1992) Evidence of dysfunction of a prefrontal-limbic network in schizophrenia: a magnetic resonance imaging and regional cerebral blood flow study of discordent monozygotic twins. Am J Psychiatry 149:890–897

    PubMed  CAS  Google Scholar 

  • Wynne RD, Kornetsky C (1960) The effects of chlorpromazine and secobarbital on the reaction times of chronic schizophrenics. Psychopharmacologia 1:294–302

    Article  PubMed  CAS  Google Scholar 

  • Young AMJ, Joseph MH, Gray JA (1993) Latent inhibition of conditioned dopamine release in rat nucleus accumbens. Neuroscience 54:5–9

    Article  PubMed  CAS  Google Scholar 

  • Zee RF, Weinberger DR (1986) Relationship between CT scan findings and neuropsychological performance in chronic schizophrenia. Psychiat Clin North Am 9:49–61

    Google Scholar 

  • Zemishlany Z, Thorne AE (1991) Anticholinergic challenge and cognitive functions: a comparison between young and elderly normal subjects. Isr J Psychiatry Relat Sci 28:32–41

    PubMed  CAS  Google Scholar 

  • Zipursky RB, Lim KO, Sullivan EV, Browm BW, Pfefferbaum A (1992) Widespread cerebral gray matter volume deficits in schizophrenia. Arch Gen Psychiatry 49:195–205

    PubMed  CAS  Google Scholar 

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Authors
  1. William O. Faustman
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  2. Anne L. Hoff
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Editors and Affiliations

  1. Department of Psychiatry, Washington University, School of Medicine, 4940 Children’s Place, St. Louis, MO 63110-1093, USA

    John G. Csernansky (M.D.) (M.D.)

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© 1996 Springer-Verlag Berlin Heidelberg

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Faustman, W.O., Hoff, A.L. (1996). Effects of Antipsychotic Drugs on Neuropsychological Measures. In: Csernansky, J.G. (eds) Antipsychotics. Handbook of Experimental Pharmacology, vol 120. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61007-3_15

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  • DOI: https://doi.org/10.1007/978-3-642-61007-3_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64653-9

  • Online ISBN: 978-3-642-61007-3

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