Adenoma and Carcinoma, Pancreatic Islets, Rat

  • James E. Heath
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)

Abstract

Adenomas of the pancreatic islets may not be visible grossly, or they may occur as pale to reddish, usually spherical nodules 3-5 mm or more in diameter within the pancreas. Carcinomas may appear grossly as round or irregular flesh-colored to dark red nodules up to 10 mm or more in diameter. Larger and more aggressive carcinomas on rare occasions may present as diffusely infiltrative masses which involve the duodenum or other abdominal organs.

Synonyms

Islet cell adenoma islet cell carcinoma islet cell tumor, benign and malignant pancreatic endocrine tumor, benign and malignant insulinoma gastrinoma apudoma alpha cell tumor beta cell tumor 

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References

  1. Berdjis CC (1963) Protracted effects of repeated doses of Xray irradiation in rats. Exp Mol Pathol 2:157–172PubMedCrossRefGoogle Scholar
  2. Burek JD (1978) Pathology of aging rats. CRC Press, West Palm Beach, pp 54–58Google Scholar
  3. Capen CC, Martin SL (1969) Hyperinsulinism in dogs with neoplasia of the pancreatic islets: a clinical, pathologic, and ultrastructural study. Pathol Vet 6()4):309–341PubMedCrossRefGoogle Scholar
  4. Caywood DD, Wilson JW, Hardy RM, Shull RM (1979) Pancreatic islet cell adenocarcinoma: clinical and diagnostic features of six cases. J Am Vet Med Assoc 174:714–717PubMedGoogle Scholar
  5. Chick WL, Warren S, Chute RN, Like AA, Lauris V, Kitchen KC (1977) A transplantable insulinoma in a rat. Proc Natl Acad Sci USA 74()2):628–632PubMedCrossRefGoogle Scholar
  6. DeLellis RA, Wolfe HJ (1981) The polypeptide hormoneproducing cells and their tumors: an immunohistochemical analysis. Methods Achiev Exp Pathol 10:190–220PubMedGoogle Scholar
  7. Drazner FH (1981) Canine gastrinoma: a condition analogous to the Zollinger-Ellison syndrome in man. Calif Vet 11: 6–11Google Scholar
  8. Friesen SR (1982) Tumors of the endocrine pancreas. N Engl J Med 306:580–590PubMedCrossRefGoogle Scholar
  9. Gilbert C, Gillman J (1958) Spontaneous neoplasms in the albino rat. S Afr J Med Sci 23:257–272Google Scholar
  10. Haseman JK, Arnold J, Eustis SL (1990) Tumor incidences in Fischer 344 rats: NTP historical data. In: Boorman GA Eustis SL Elwell MR Montgomery CA McKenzie WF(eds) Pathology of the Fischer rat: reference and atlas. Academic, San Diego, pp 555–564Google Scholar
  11. Hawkins KL, Summers BA, Kuhajda FP, Smith CA (1987) Immunocytochemistry of normal pancreatic islets and spontaneous islet cell tumors in dogs. Vet Pathol 24:170–177PubMedGoogle Scholar
  12. Hayashi Y, Furukawa H, Hasegawa T (1972) Pancreatic tumors in rats induced by 4-nitroquinoline 1-oxide. In: Nakahara W Takayama S Sugimura T Odashima S(eds) Topics in chemical carcinogenesis. University Park Press, Baltimore, pp 53–72Google Scholar
  13. Jones EE (1964) Spontaneous hyperplasia of the pancreatic islets associated with glucosuria in hybrid mice. Wenner Gren Cent Int Symp Ser 3:189–191Google Scholar
  14. Jones TC, Hunt RD (1983) Veterinary pathology, 5th edn. Lea and Febiger, Philadelphia, pp 1633–1635Google Scholar
  15. Longnecker DS, Wilson GL (1991) Pancreas. In: Haschek WM Rousseaux CG(eds) Handbook of toxicologic pathology. Academic, San Diego, pp 253–278Google Scholar
  16. McMartin DN, Sahota PS, Gunson DE, Hsu HH, Spaet RH (1992) Neoplasms and related proliferative lesions in control Sprague-Dawley rats from carcinogenicity studies. Historical data and diagnostic considerations. Toxicol Pathol 20()2): 212–225PubMedCrossRefGoogle Scholar
  17. Njoku CO, Strafuss AC, Dennis SM (1972) Canine islet cell neoplasia: a review. J Am Anim Hosp Assoc 8:284–290Google Scholar
  18. Noltenius H (1988) Human oncology. Pathology and clinical characteristics, 2nd edition, vol I. Urban and Schwarzenberg, Baltimore, pp 425–449Google Scholar
  19. Pour PM, Rivenson A (1989) Induction of a mixed ductalsquamous-islet cell carcinoma in a rat treated with a tobaccospecific carcinogen. Am J Pathol 134()3):627–631PubMedGoogle Scholar
  20. Robbins SL, Cotran RS, Kumar V (1984) Pathologic basis of disease, 3rd edn. Saunders, Philadelphia, pp 986–989Google Scholar
  21. Sass B, Vernon ML, Peters RL, Kelloff GJ (1978) Mammary tumors, hepatocellular carcinomas and pancreatic islet changes in C3H-Avy mice. J Natl Cancer Inst 60:611–621PubMedGoogle Scholar
  22. Schoental R, Fowler ME, Coady A (1970) Islet cell tumors of the pancreas found in rats given pyrrolizidine alkaloids from Amsinckia intermedia Fisch and Mey and from Heliotropium supinum L. Cancer Res 30:2127–2131PubMedGoogle Scholar
  23. Seibold HR, Wolf RH (1973) Neoplasms and proliferative lesions in 1065 nonhuman primate necropsies. Lab Anim Sci 23:533–539PubMedGoogle Scholar
  24. Spencer AJ, Andreu M, Greaves P (1986) Neoplasia and hyperplasia of pancreatic endocrine tissue in the rat: an immunocytochemical study. Vet Pathol 23:11–15PubMedGoogle Scholar
  25. Strandberg JD (1987) Neoplastic diseases. In:Van Hoosier GL McPherson CW(eds) Laboratory hamsters. Academic, Orlando, pp 157–168Google Scholar
  26. Stromberg PC, Wilson F, Capen CC (1983) Immunocytochemical demonstration of insulin in spontaneous pancreatic islet cell tumors of Fischer rats. Vet Pathol 20:291–297PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • James E. Heath
    • 1
  1. 1.Southern Research InstituteBirminghamUSA

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