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The Ovary

  • A. Helvacioglu
Conference paper

Abstract

In the words of Albert Schweitzer, the most precious thing about man, however creative he may be, is man himself. “Man” endures through the intricate reproductive process in which the ovary plays a lead role. The ovary is a multicompartmental structure with different and variable biologic properties. Responding to cyclic pituitary gonadotropin secretion, it secretes sex steroids and glycoproteins and produces the ovum. Current information suggests that the ovary is very instrumental in the activities of the hypothalamo-pituitary-ovarian axis.

Keywords

Luteinizing Hormone Granulosa Cell Follicle Stimulate Hormone Corpus Luteum Follicular Fluid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Simpson ER, Mahendroo MS, Means GD, Kilgore MW, Corbin CJ, Mendelson CR (1993) Tissue-specific promoters regulate aromatase cytochrome P450 expression. Clin Chem 39:317–324PubMedGoogle Scholar
  2. 2.
    Mason AJ, Niahll HD, Seeburgh PH (1986) Structure of two human ovarian inhibins. Biochem Biophys Res Commun 35:957–964CrossRefGoogle Scholar
  3. 3.
    Le Nestour E, Marraoui J, Lahlou M, Roger M Ziegler DE, Bouchard PH (1993) Role of estradiol in the rise in FSH levels during the luteal-follicular transition. J Clin Endocrinol Metab 77:439–442PubMedCrossRefGoogle Scholar
  4. 4.
    Hsueh AJW, Dahl KD, Vaughan J et al. (1987) Heterodimers and homodimers of inhibin subunits have different paracrine action in the modulation of luteinizing hormone-stimulated androgen biosynthesis. Proc Natl Acad Sci USA 84:5082–5086PubMedCrossRefGoogle Scholar
  5. 5.
    Roberts VJ, Barth S, El-Roeiy A, Yen SSC (1993) Expression of inhibin/activin subunits and follistatin messenger ribonucleic acids and proteins in ovarian follicles and the corpus luteum during the human menstrual cycle. J Clin Endocrinol Metab 77:1402–1410PubMedCrossRefGoogle Scholar
  6. 6.
    Yamoto M, Minami S, Nakano R (1993) Immunohistochemical localization of inhibin subunits in polycystic ovary. J Clin Endocrinol Metab 77:859–862PubMedCrossRefGoogle Scholar
  7. 7.
    Shimonaka M, Inouye S, Shimasaki S, Ling N (1991) Follistatin binds to both activin and inhibin through the common beta-subunit. Endocrinology 128:3313–3315PubMedCrossRefGoogle Scholar
  8. 8.
    Lobie PE, Breipohl W, Aragon JG, Waters MJ (1990) Cellular localization of the growth hormone receptor/binding protein in the male and female reproductive systems. Endocrinology 126:2214–2221PubMedCrossRefGoogle Scholar
  9. 9.
    Amit T, Dirnfeld M, Barkey RJ, Peleg I, Hacham H, Abramovici H, Blumenfeld Z (1993) Growth hormone-binding protein (GH-BP) levels in follicular fluid from human periovulatory follicles: correlation with serum GH-BP levels. J Clin Endocrinol Metab 77:33–39PubMedCrossRefGoogle Scholar
  10. 10.
    Barreca A, Artini PG, Del Monte P, Ponzani P, Pasquini P, Cariola G, Volpe A, Genazzani AR, Giordano G, Minuto F (1993) In vivo and in vitro effect of growth hormone on estradiol secretion by human granulosa cells. J Clin Endocrinol Metab 77:61–67PubMedCrossRefGoogle Scholar
  11. 11.
    Gomez E, Tarin JJ, Pellicer (1993) Oocyte maturation in humans: the role of gonadotropins and growth factors. Fertil Steril 60:40–46PubMedGoogle Scholar
  12. 12.
    Di Simone N, Castellani R, Lanzone A, Caruso A, Mancuso S (1993) Human GH enhances P production by human luteal cells in vitro. II. Evidence of a distinct effect of two luteal cell types. Fertil Steril 60:47–52PubMedGoogle Scholar
  13. 13.
    Nobels F, Dewailly D (1992) Puberty and polycystic ovarian syndrome: the insulin/ insulin-like growth factor I hypothesis. Fertil Steril 58:655PubMedGoogle Scholar
  14. 14.
    Tiitinen AE, Laatikainen TJ, Seppala MT (1993) Serum levels of insulin-like growth factor binding protein-1 and ovulatory responses to clomiphen citrate in women with polycystic ovarian disease. Fertil Steril 60:58–62PubMedGoogle Scholar
  15. 15.
    Acar B, Kadanali S (1993) Diminished growth hormone response to L-dopa in polycystic ovarian disease. Fertil Steril 60:984–987PubMedGoogle Scholar
  16. 16.
    McNatty KP, Smith DM, Makris A, Osathanondh R, Ryan KJ (1979) The microenvironment of the human antral follicle: interrelationships among the steroid levels in antral fluid, the population of granulosa cells, and the status of the oocyte in vivo and in vitro. J Clin Endocrinol Metab 49.851–860PubMedCrossRefGoogle Scholar
  17. 17.
    Horie K, Takakura K, Fujiwara H, Suginami H, Liao S, Mori T (1992) Immunohistochemical localization of androgen receptor in the human ovary throughout the menstrual cycle in relation to estrogen and progesterone receptor expression. Hum Reprod 7:184–190PubMedGoogle Scholar
  18. 18.
    Zelinski-Wooten MB, Hess DL, Baughman WL, Molskness TA, Wolf DP, Stouffer RL (1993) Administration of an aromatase inhibitor during the late follicular phase of gonadotropin treated cycles in rhesus monkeys: effects on follicle development, oocyte maturation, and subsequent luteal function. J Clin Endocrinol Metab 76:988PubMedCrossRefGoogle Scholar
  19. 19.
    Haning RV, Hackett Jr RJ, Flood CA, Loughlin JS, Zhao QY, Longcope C (1973) Testosterone, a follicular regulator: key to anovulation. J Clin Endocrinol Metab 77:710–715CrossRefGoogle Scholar
  20. 20.
    Palumbo A, Pourmotabbed G, Carcangiu ML, Andrade-Gordon P, Roa L, DeCherney A, Naftolin F (1993) Immunohistochemical localization of renin and angiotensin in the ovary: comparison between normal women and patients with histologically proven PCOD. Fertil Steril 60:280–284PubMedGoogle Scholar
  21. 21.
    International Federation of Fertility Societies (IFFS) (1993) Fertility drugs and ovarian cancer. Fertil Steril 60:406–408Google Scholar
  22. 22.
    Hylka VW, Dizerega GS (1991) Reproductive hormones and their mechansim of action. In: Mishell DR, Davajan V, Lobo RA (eds) Infertility, contraception and reproductive endocrinology. 3rd edn. Blackwell Scientific, Boston, p 47Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • A. Helvacioglu

There are no affiliations available

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