Peripheral Circulation: Fundamental Concepts, Comparative Aspects of Control in Specific Vascular Sections, and Lymph Flow

  • J. Holtz


W(illiam) H(arvey) shows by the way the heart is made that the blood is perpetually driven from the lungs into the aorta…. He shows by means of a ligature the passage of the blood from arteries to the veins. Hence it is demonstrated that the perpetual movement of the blood takes place in a circle, owing to the beat of the heart (Lumleian Lecture to the College of Physicians in London on April 17, 1616).


Central Venous Pressure Transmural Pressure Myogenic Response Sympathetic Nerve Ending Volume Receptor 
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  1. 1.
    Abboud FM (1982) Pathophysiology of hypotension and shock. In: Hurst JW (ed) The heart, arteries and veins. McGraw-Hill, New York, pp 452–463Google Scholar
  2. 2.
    Admiraal PJJ, Derkx FHM, Danser AHJ, Pieterman H, Schalekamp MADH (1990) Metabolism and production of angiotensin in subjects with renal artery stenosis. Hypertension 15:44–55PubMedGoogle Scholar
  3. 3.
    American Society of Hypertension (1992) Recommendation for routine blood pressure measurement by indirect cuff sphygmomanometry. Am J Hypertension 3:207–212Google Scholar
  4. 4.
    Anonymus (1993) Memorandum from a World Health Organization/International Society of Hypertension meeting: 1993 guidelines for the management of mild hypertension. Hypertension 22:392–405Google Scholar
  5. 5.
    Anrep G (1912) On local vascular reactions and their interpretation. J Physiol [Lond] 45:318–327Google Scholar
  6. 6.
    Aukland K (1994) Why don’t our feet swell in the upright position? News Physiol Sci 9:214–219Google Scholar
  7. 7.
    Aukland K, Reed RK (1993) Interstitial-lymphatic mechanisms in the control of extracellular fluid volume. Physiol Rev 73:1–78PubMedGoogle Scholar
  8. 8.
    Bauer RD, Busse R (1982) Biophysik des Kreislaufs. In: Busse R (ed) Kreislaufphysiologie. Thieme, Stuttgart, pp 3–40Google Scholar
  9. 9.
    Bayliss WM (1902) On the local reactions of the arterial wall to changes in internal pressure. J Physiol [Lond] 28:220–231Google Scholar
  10. 10.
    Berecek KH, Brody MJ (1992) Evidence for a neurotransmitter role for epinephrine derived from the adrenal medulla. Am] Physiol 242:H593-H601Google Scholar
  11. 11.
    Björnberg J, Albert U, Mellander S (1990) Resistance responses in proximal arterial vessels, arterioles and veins during reactive hyperemia in skeletal muscle and their underlying regulatory mechanisms. Acta Physiol Scand 139:535–550PubMedGoogle Scholar
  12. 12.
    Blair DA, Glover WE, Greenfield ADM, Roddie IC (1959) Excitation of cholinergic vasodilator nerves to human skeletal muscle during emotional stress. J Physiol 148:633–647PubMedGoogle Scholar
  13. 13.
    Brengelmann GL (1989) Body temperature regulation. In: Patton HD, Fuchs AF, Hille B, Scher AM, Steiner R (eds) Textbook of physiology. Saunders, Philadelphia, pp 1584–1596Google Scholar
  14. 14.
    Burnett JC, Kao PC, Hu DC (1986) Atrial natriuretic peptide elevation in congestive heart failure in the human. Science 231:1145–1150PubMedGoogle Scholar
  15. 15.
    Busse R (1995) Gefäßsytem und Kreislaufregulation (1995) In: Schmidt F, Thews G (eds) Physiologie des Menschen. Springer, Berlin, Heidelberg New York, pp 498–561Google Scholar
  16. 16.
    Busse R, Fleming I (1993) The endothelial organ. Curr Opinion Cardiol 8:719–727Google Scholar
  17. 17.
    Busse R, Fleming I, Schini VB (1995) Nitric oxid formation in the vascular wall: regulation and functional implications. Curr Topics Microbiol Immunol 196:7–18Google Scholar
  18. 18.
    Calaresu FR, Yardley CP (1988) Medullary basal sympathetic tone. Ann Rev Physiol 50:511–524Google Scholar
  19. 19.
    Campbell DJ (1987) Circulating and tissue angiotensin systems. J Clin Invest 79:1–6PubMedGoogle Scholar
  20. 20.
    Campbell DJ, Kladis A (1991) Simultaneous radioimmunoassay of six angiotensin peptides in arterial and venous plasma of man. J Hypertens 9:265–274PubMedGoogle Scholar
  21. 21.
    Chien S, Jan KM (1973) Red cell aggregation by macromolecules: roles of surface adsorption and electrostatic repulsion. J Supramol Struct 1:185–231Google Scholar
  22. 22.
    Chien S, Usami S, Shalak R (1984) Blood flow in small tubes. In: Renkin EM, Michel CC (eds) Handbook of physiology, Section 2: The cardiovascular system, Vol. IV: Microcirculation, Pt. 1. Am Physiol Soc, Bethesda, Maryland, pp 217–249Google Scholar
  23. 23.
    Cohen RA, Weisbrod RM (1988) Endothelium inhibits norepinephrine release from adrenergic nerves of rabbit carotid artery. Am J Physiol 254:H871–H878PubMedGoogle Scholar
  24. 24.
    Cohn JN (1988) Current therapy of the failing heart. Circulation 18:1099–1118Google Scholar
  25. 25.
    Cohn JN (1995) Heart failure. In: Willerson JT, Cohn JN (eds) Cardiovascular medicine. Churchill Livingstone, New York, pp 947–979Google Scholar
  26. 26.
    Cohn JN, Levine TB, Olivari MT (1984) Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure. N Engl J Med 311:819–827PubMedGoogle Scholar
  27. 27.
    Cowley AW Jr, Liard JF, Guyton AC (1973) Role of the baroreceptor reflex in daily control of asterial blood pressure and other variables in dogs. Circ Res 32:564–578PubMedGoogle Scholar
  28. 28.
    Davies PF (1989) How do vascular endothelial cells respond to flow?. News Physiol Sci 4:22–25Google Scholar
  29. 29.
    Davis MJ (1991) Myogenic response gradient in an arteriolar network. In: Mulvany MJ, Alkjaer C, Heagerty AM, Nyborg NCB, Strandgaard S (eds) Proceedings of the 3rd International Symposium on Resistance Arteries. Elsevier, Amsterdam, pp 51–55Google Scholar
  30. 30.
    De Bold AJ, Borenstein AT, Veress AT (1981) A rapid and potent natriuretic response to intravenous atrial myocardial extract in rats. Life Sci 28:89–94PubMedGoogle Scholar
  31. 31.
    Dull RO, Davies PF (1991) Flow modulation of agonist (ATP)-response Ca2+-coupling in vascular endothelial cells. Am J Physiol 261:H149–H154PubMedGoogle Scholar
  32. 32.
    Dzau VJ, Burt DW, Pratt RE (1988) Molecular biology of the renin angiotensin system. Am J Physiol 255:F563-F573PubMedGoogle Scholar
  33. 33.
    Dzau VJ, Pratt RE (1992) Renin angiotensin system. In: Fozzard HA, Haber E, Jennings RB, Katz AM, Morgan HE (eds) The heart and the cardiovascular System. Raven, New York, pp 1817–1849Google Scholar
  34. 34.
    Eichna LW (1960) The George E. Brown Memorial Lecture: circulatory congestion and heart failure. Circulation 22:864–892PubMedGoogle Scholar
  35. 35.
    Engeset A, Olszewski W, Jaeger PM, Sokolowski J, Theodorsen L (1977) Twenty-four hour variation in flow and composition of leg lymph in normal men. Acta Physiol Scand 99:140–148PubMedGoogle Scholar
  36. 36.
    Ferrara N (1993) Vascular endothelial growth factor. Trends Cardiovasc Med 3:244–250PubMedGoogle Scholar
  37. 37.
    Folkow B (1964) Description of the myogenic hypothesis. Circ Res 15 [Suppl 1]: 279–287PubMedGoogle Scholar
  38. 38.
    Folkow B (1990) Salt and hypertension. News Physiol Sci 5:220–2224Google Scholar
  39. 39.
    Francis GS, Goldsmith SR, Levine TB (1984) The neurohumoral axis in congestive heart failure. Ann Intern Med 101:370–378PubMedGoogle Scholar
  40. 40.
    Frangos JA, Eskin SG, McIntire LV, Ives CL (1985) Flow effects on prostacyclin production by cultured human endothelial cells. Science 227:1477–1479PubMedGoogle Scholar
  41. 41.
    Furchgott RF (1983) Role of endothelium in response of vascular smooth muscle. Circ Res 53:557–573PubMedGoogle Scholar
  42. 42.
    Furchtgott RF, Zawadzki JV (1980) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288:373–376Google Scholar
  43. 43.
    Gaehtgens P (1982) Mikrozirkulation. In: Busse R (ed) Kreislaufphysiologie. Thieme, Stuttgart, pp 70–103Google Scholar
  44. 44.
    Gardner DG (1994) Molecular biology of the natriuretic peptides. Trends Cardiovasc Med 4:159–165PubMedGoogle Scholar
  45. 45.
    Gauer OH, Henry JP, Behn C (1970) The regulation of extracellular fluid volume. Ann Rev Physiol 32:547–589Google Scholar
  46. 46.
    Gewirtz H (1991) The coronary circulation: limitations of current concepts of metabolic control. News Physiol Sci 6:265–268Google Scholar
  47. 47.
    Gorman MW, Sparks HE (1991) The unanswered question. News Physiol Sci 6:191–193Google Scholar
  48. 48.
    Greenfield ADM (1966) Survey of the evidence for active neurogenic vasodilation in man. Fed Proc 25:1607–1610PubMedGoogle Scholar
  49. 49.
    Griffith TM, Edwards DH (1990) Myogenic autoregulation of flow may be inversely related to endothelium-derived relaxing factor activity. Am J Physiol 258:H1171–H1180PubMedGoogle Scholar
  50. 50.
    Griffith TM, Edwards DH, Davies RL, Harrison TJ, Evans KT (1987) EDRF coordinates the behaviour of vascular resistance vessels. Nature 329:442–445PubMedGoogle Scholar
  51. 51.
    Groves P, Kurz S, Drexler H (1994) The role of bradykinin in basal and flow-mediated endothelium-dependent vasodilation in the human coronary circulation (abstr.). Circulation 90:I36Google Scholar
  52. 52.
    Guyton AC (1986) Physiology and treatment of circulatory shock. In: Guyton AC (ed) Textbook of medical physiology. Saunders, Philadelphia, pp 326–335Google Scholar
  53. 53.
    Guyton AC, Coleman TG, Cowley AW Jr (1972) Arterial pressure regulation: overriding dominance of the kidney in the longterm regulation and in hypertension. Am J Med 52:584–694PubMedGoogle Scholar
  54. 54.
    Hagen G (1839) Über die Bewegungen des Wassers in engen zylindrischen Röhren. Ann Phys Chem Poggendorf 46:422–442Google Scholar
  55. 55.
    Hathaway DR, Adam LP, Wilensky RL, March KL (1995) Vascular muscle structure and function. In: Willersion JT, Cohn JN (eds) Cardiovascular medicine. Churchill Livingstone, New York pp 1042–1052Google Scholar
  56. 56.
    Henry JP, Gauer OH (1950) The influence of temperature upon venous pressure in the foot. J Clin Invest 29:855–862PubMedGoogle Scholar
  57. 57.
    Holtz J, Förstermann U, Pohl U, Giesler M, Bassenge E (1984) Flow dependent endothelium-mediated dilation of epicardial coronary arteries in conscious dogs: effect of cyclooxygenase inhibition. J Cardiovasc Pharmacol 6:1161–1169PubMedGoogle Scholar
  58. 58.
    Holtz J, Goetz RM (1994) Vascular renin-angiotensin -system, endothelial function and arteriosclerosis? Basic Res Cardiol 89:71–86PubMedGoogle Scholar
  59. 59.
    Holtz J, Höffler D (1993) Alpha-1-Rezeptorenblocker: Klinik und Pharmakologie. Aesopus, BaselGoogle Scholar
  60. 60.
    Holtz J, Münzel T, Bassenge E (1987) Atrial natriuretic factor in man. Z Kardiol 76:655–670PubMedGoogle Scholar
  61. 61.
    Hutcheson IR, Griffith TM (1991) Release of endothelium-derived relaxing factor is modulated both by frequency and amplitude of pulsatile flow. Am J Physiol 261:H257-H262PubMedGoogle Scholar
  62. 62.
    Jänig W (1988) Pre- and postganglionic vasoconstrictor neurons: differentiation, types, and discharge properties. Ann Rev Physiol 50:525–539Google Scholar
  63. 63.
    Järhult J, Meilander S (1974) Autoregulation of capillary hydrostatic pressure in skeletal musle during regional arterial hypo- and hypertension. Acta Physiol Scand 91:32–41PubMedGoogle Scholar
  64. 64.
    Johnson JM (1989) Circulation to the skin. In: Patton HD, Fuchs AF, Hille B, Scher AM, Steiner R (eds) Textbook of physiology. Saunders, Philadelphia, pp 898–910Google Scholar
  65. 65.
    Johnson PC (1980) The myogenic response. In: Bohr DF, Somlyo AP, Sparks HV (eds) Handbook of physiology, Sect. 2: the cardiovascular system, vol. II: Vascular smooth muscle. Am Physiol Soc, Bethesda, Maryland, pp 409–442Google Scholar
  66. 66.
    Kaley G, Altura BM (1977) Microcirculation, vol I. University Park Press, BaltimoreGoogle Scholar
  67. 67.
    Klagsbrun M, Dluz S (1993) Smooth muscle cell and endothelial cell growth factors. Trends Cardiovasc Med 3:213–217PubMedGoogle Scholar
  68. 68.
    Kubik S (1993) Anatomie des Lymphgefäßsystems. In: Foldi M, Kubik S (eds) Lehrbuch der Lymphologie. Fischer, Stuttgart pp 1–201Google Scholar
  69. 69.
    Kuchan MJ, Jo H, Frangos JA (1994) Role of G proteins in shear stress-mediated nitric oxide production by endothelial cells. Am J Physiol 267:C753-C758PubMedGoogle Scholar
  70. 70.
    Lansman JB, Hallam TJ, Rink TJ (1987) Single stretch-activated ion channels in vascular endothelial cells as mechanotransducers? Nature 235:811–813Google Scholar
  71. 71.
    Levick JR, Michel CC (1978) The effects of position and skin temperature on the capillary pressures in the fingers and the toes. J Physiol 274:97–109PubMedGoogle Scholar
  72. 72.
    Marrero MB, Schieffer B, Paxton WG, Heerdt L, Berk BC, Delafontaine P, Bernstein KE (1995) Direct stimulation of JAK/STAT pathway by the angiotensin II AT1 receptor. Nature 375:247–250PubMedGoogle Scholar
  73. 73.
    Mattson DL, Lu SH, Roman RJ, Cowley AW Jr (1993) Relationship between renal perfusion pressure and blood flow in different regions of the kidney. Am J Physiol 264:R578-R583PubMedGoogle Scholar
  74. 74.
    Meininger GA, Davis MJ (1992) Cellular mechanism involved in the vascular myogenic response (brief review). Am J Physiol 263:H647-H659PubMedGoogle Scholar
  75. 75.
    Mellander S, Johansen B (1968) Control of resistance, exchange and capacitance functions in the peripheral circulation. Pharmacol Rev 20:117–196PubMedGoogle Scholar
  76. 76.
    Meschia G (1983) Circulation to female reproductive organs: In: Shepherd JT, Abboud FM (eds) Handbook of physiology, Sect. 2: The cardiovascular system, vol. III: Peripheral circulation and organ blood flow. Am Physiol Soc, Bethesda, pp 241–269Google Scholar
  77. 77.
    Miller VM (1991) Interactions between neural and endothelial mechanisms in control of vascular tone. News Physiol Sci 6:60–63Google Scholar
  78. 78.
    Mo M, Eskin SG, Schilling WP (1991) Flow-induced changes in Ca2+-signalling of vascular endothelial cells: effect of shear stress and ATP. Am J Physiol 260:H1698-H1707PubMedGoogle Scholar
  79. 79.
    Mulvany MJ (1991) Are vascular abnormalities a primary cause or secondary consequence of hypertension? Hypertension 18 [Suppl I]: 152–157Google Scholar
  80. 80.
    Mulvany MJ (1989) Structure and function of peripheral vascular smooth muscle in hypertension. J Cardiovasc Pharmacol 14 [Suppl 6]: S85-S89PubMedGoogle Scholar
  81. 81.
    Neil E (1984) Peripheral circulation: historical aspects. In: Shepherd JT, Abboud FM (eds) Handbook of physiology, Sect. 2: the cardiovascular system, vol III: peripheral circulation and organ blood flow, Pt. 1. Am Physiol Soc, Bethesda, Maryland, pp 1–19Google Scholar
  82. 82.
    Olesen SO, Clapham DE, Davies PF (1988) Haemodynamic shear stress activates a K+-current in vascular endothelial cells. Nature 331:168–170PubMedGoogle Scholar
  83. 83.
    Olszewski WL (1985) Peripheral lymph: formation and immune function. CRC Press, Boca RatonGoogle Scholar
  84. 84.
    Olszewski WL, Engeset A (1980) Intrinsic contractility of prenodal lymph vessels and lymph flow in human leg. Am J Physiol 239:H775-H783PubMedGoogle Scholar
  85. 85.
    Palmer RMJ, Ferrige FG, Moncada S (1987) Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327:524–526PubMedGoogle Scholar
  86. 86.
    Pohl U, Busse R, Kuon E, Bassenge E (1986) Pulsatile perfusion stimulates the release of endothelial autocoids. J Appl Cardiol 1:215–235Google Scholar
  87. 87.
    Roman RJ, Zou AP (1993) Influence of the renal medullary circulation on the control of sodium excretion. Am J Physiol 265:R963-R973PubMedGoogle Scholar
  88. 88.
    Rowell LB (1974) Human cardiovascular adjustments to exercise and thermal stress. Physiol Rev 54:75–159PubMedGoogle Scholar
  89. 89.
    Rubanyi GM, Romero JC, Vanhoutte PM (1986) Flow-induced release of endothelium-derived relaxing factor. Am J Physiol 250:H1145-H1149PubMedGoogle Scholar
  90. 90.
    Rushmer RF (1961) Peripheral vascular control. In: Rushmer RF (ed) Cardiovascular dynamics. Saunders, Philadelphia, pp 98–130Google Scholar
  91. 91.
    Rushmer RF (1961) Embryologie development and congenital malformations of the heart. In: Rushmer EF (ed) Cardiovascular dynamics. Saunders, Philadelphia, pp 390–434Google Scholar
  92. 92.
    Saito Y, Eraslan A, Lockard V, Hester RL (1994) Role of venular endothelium in control of arteriolar diameter during functional hyperemia. Am J Physiol 267:H1227–H1231PubMedGoogle Scholar
  93. 93.
    Saltin B (1985) Hemodynamic adaptations to exercise. Am J Cardiol 55:42D–47DPubMedGoogle Scholar
  94. 94.
    Scher AM (1989) Cardiovascular control. In: Patton HD, Fuchs AF, Hille B, Scher AM, Steiner R (eds) Textbook of physiology. Saunders, Philadelphia, pp 972–990Google Scholar
  95. 95.
    Schretzenmayr A (1933) Über regulatorische Vorgänge an Muskelarterien. Pfluegers Arch 232:743–748Google Scholar
  96. 96.
    Selkurt EE, Womack I, Dailey WN (1965) Mechanisms of natriuresis and diuresis during elevated renal arterial pressure. Am J Physiol 209:95–99PubMedGoogle Scholar
  97. 97.
    Shen J, Luscinskas FW, Connolly A, Dewey CF, Gimbrone MA (1992) Fluid shear stress modulates cytosolic free calcium in vascular endothelial cells. Am J Physiol 262:C384-C390PubMedGoogle Scholar
  98. 98.
    Somylo AP, Somylo AV (1991) Smooth muscle structure and function. In: Fozzard HA, Jennings RB, Haber E, Katz AM, Morgan HE (eds) The Heart and the cardiovascular system. Raven, New York, pp 1295–1324Google Scholar
  99. 99.
    Staessen J, Amery A, Fragard R (1990) Isolated systolic hypertension in the elderly. J Hypertens 8:393–403PubMedGoogle Scholar
  100. 100.
    Starke K (1987) Presynaptic alpha-autoreceptors. Rev Physiol Biochem Pharmacol 107:1–124Google Scholar
  101. 101.
    Starke K (1977) Regulation of noradrenalin release by presynaptic receptor systems. Rev Physiol Biochem Pharmacol 77:1–124PubMedGoogle Scholar
  102. 102.
    Stiles GL (1991) Adenosin receptors: physiological regulation and biochemical mechanism. News Physiol Sci 6:161–165Google Scholar
  103. 103.
    Task Force on Blood Pressure Control in Children (1988) Report on the second task force on blood pressure control in children 1987. Pediatrics 79:1–19Google Scholar
  104. 104.
    Timmermans PBWM, Wong PC, Chiu AT, Herblin WF, Benfield P, Carini DJ, Lee RL, Wexler RR, Saye JAM, Smith RD (1993) Angiotensin II receptors and angiotensin II receptor antagonists. Pharmacol Rev 45:205–251PubMedGoogle Scholar
  105. 105.
    Toda N, Okamura T (1992) Regulation by nitroxidergic nerves of arterial tone. News Physiol Sci 7:148–152Google Scholar
  106. 106.
    Tresfamariam B, Weisbrod RM, Cohen RA (1989) The endothelium inhibits activation by calcium of vascular neurotransmission. Am J Physiol 257:H1871-H1877Google Scholar
  107. 107.
    Urata H, Kinoshita A, Perez DM, Misono KS, Bumpus FM, Graham RM, Husain A (1991) Cloning of the gene and cDNA for human heart chymase. J Biol Chem 266:17173–17179PubMedGoogle Scholar
  108. 108.
    Valentin JP, Humphrey M (1993) Urodilatin A paracrine renal natriuretic peptide. Semin Nephrol 13:61–70PubMedGoogle Scholar
  109. 109.
    Vizi ES, Kiss J, Elenkov IJ (1991) Presynaptic modulation of cholinergic and noradrenergic neurotransmission: interaction between them. News Physiol Sci 6:119–123Google Scholar
  110. 110.
    Von Euler US (1951) The nature of adrenergic nerve mediators. Pharmacol Rev 3:247–277Google Scholar
  111. 111.
    Von Kügelen I, Starke K (1991) Noradrenalin-ATP co-transmission in the sympathetic nervous system. Trends Pharmacol Sci 12:319–324Google Scholar
  112. 112.
    Walker P, Grouzmann E, Burnier M, Waeber B (1991) The role of neuropeptide Y in cardiovascular regulation. Trends Pharmacol Sci 12:111–115PubMedGoogle Scholar
  113. 113.
    Wallin G, Elam M (1994) Insights from intraneural recordings of sympathetic nerve traffic in humans. News Physiol Sci 9:203–207Google Scholar

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