Abstract
Pulmonary blood flow is the denominator of the ventilation-perfusion ratio, V A/Q, and is of equal importance with breathing in determining the overall efficiency of pulmonary gas exchange (Table 104.1). A major hemodynamic difference between the systemic and pulmonary circulations [4,6] is that the entire cardiac output passes through the lungs — which has only about 1% of the body mass — and it does so with a mean pulmonary arterial-to-left atrial driving pressure that is less than one-tenth that of the systemic circulation. The difference is that in the pulmonary circulation the small muscular arteries and arterioles, both by their enormous number and their low basal smooth muscle tone, contribute much less to total flow resistance than their systemic counterparts.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bhattacharya J, Staub NC (1980) Direct measurement of microvascular pressures in the isolated perfused dog lung. Science 210:327–328
Deffenbach ME, Charan NB, Lakshminarayan S, Butler J (1987) The bronchial circulation: small, but a vital attribute of the lung. Am Rev Respir Dis 135:463–481
Gillis CN (1986) Pharmacological aspects of metabolic processes in the pulmonary microcirculation. Annu Rev Pharmacol Toxicol 26:183–200
Grover RF, Wagner WW Jr, McMurtry I, Reeves JT (1984) Pulmonary circulation. In: Shepherd JT, Abboud FM (eds) Handbook of physiology: the cardiovascular system. III. American Physiological Society, Bethesda, pp 103–136
Gunteroth WG, Luchtel DL, Kawabori I (1982) Pulmonary micro-circulation — tubules rather than sheet and post. J Appl physiol 53:510–515
Harris P, Heath D (1978) The human pulmonary circulation, 2nd edn. Livingston, Edinburgh
Hyman AL, Spannhake EW, Kadowitz PJ (1978) Prostaglandins and the lung. Am Rev Respir Dis 117:111–136
Mitzner W (1983) Resistance of the pulmonary circulation. Clin Chest Med 4:127–137
Staub NC (1984) Pathophysiology of pulmonary edema. In: Staub NC, Taylor AE (eds) Edema. Raven, New York
Staub NC (1990) Pathways for lung liquid clearance. In: Brigham KL, Stahlman MT (eds) Respiratory distress syndromes: molecules to man. Vanderbilt, Nashville, pp 33–43
West JB, Dollery CT, Naimark A (1964) Distribution of blood flow in isolated lung: relation to vascular and alveolar pressures. J Appl Physiol 19:713–724
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Staub, N.C., Dawson, C.A. (1996). Pulmonary and Bronchial Circulation. In: Greger, R., Windhorst, U. (eds) Comprehensive Human Physiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60946-6_105
Download citation
DOI: https://doi.org/10.1007/978-3-642-60946-6_105
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-64619-5
Online ISBN: 978-3-642-60946-6
eBook Packages: Springer Book Archive