Skip to main content

Pulmonary Gas Exchange

  • Chapter
Comprehensive Human Physiology

Abstract

In the original sense of the latin word, “respiration” means repeated inhaling and exhaling of air with the associated movements of the thorax. Respiratory movements produce air flow for the transport of O2 into lungs, and of CO2, the end product of oxidative metabolism, out of the lungs. But respiration in today’s meaning includes all the processes involved in the transport of O2 and CO2 between the environment and body tissues, performed by pulmonary ventilation, pulmonary O2 and CO2 exchange, blood circulation, and O2 and CO2 exchange in tissues. Gas exchange in tissues is intimately related to the consumption of O2 and production of CO2 by oxidative tissue metabolism whose main purpose is provision of energy for life processes.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 349.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 449.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

General References

  • Comroe JH, Forster RE, Dubois AB, Briscoe WA, Carlsen E (1962) The lung: clinical physiology and pulmonary function tests. Medical Book Publishers, Chicago

    Google Scholar 

  • Cotes JE (1979) Lung function: assessment and application to medicine. Blackwell, Oxford

    Google Scholar 

  • Crystal RG, West JB, Barnes PJ, Cherniack NS, Weibel ER (eds) (1991) The lung: scientific foundations, 2 vols. Raven, New York

    Google Scholar 

  • Farhi LE, Tenney SM (eds) (1987) Handbook of physiology, section 3: the respiratory system, vol 3: gas exchange. American Physiological Society, Bethesda

    Google Scholar 

  • Fenn WO, Rahn H (eds) (1964/1965) Handbook of physiology, section 3: respiration, 2 vols. American Physiological Society, Washington DC

    Google Scholar 

  • Weibel ER (1984) The pathway for oxygen. Harvard University Press, Cambridge MA

    Google Scholar 

  • West JB (1985) Respiratory physiology, the essentials. Williams and Wilkins, Baltimore

    Google Scholar 

  • West JB (ed) (1980) Pulmonary gas exchange, 2 vols. Academic, New York

    Google Scholar 

Specific References

  1. Anthonisen NR, Fleetham JA (1987) Ventilation: total, alveolar, and dead space. In: Farhi LE, Tenney SM (eds) Handbook of physiology, section 3: respiratory system, vol 4: gas exchange. American Physiological Society, Bethesda, pp 113–129

    Google Scholar 

  2. Crapo JD, Crapo RO, Jensen RL, Mercer RR, Weibel ER (1988) Evaluation of lung diffusing capacity by physiological and morphometric techniques. J Appl Physiol 64:2083–2091

    PubMed  CAS  Google Scholar 

  3. Engel LA, Paiva M (eds) (1985) Gas mixing and distribution in the lung. Dekker, New York (Lung biology in health and disease, vol 25)

    Google Scholar 

  4. Farhi LE (1987) Ventilation-perfusion relationships. In: Farhi LE, Tenney SM (eds) Handbook of physiology, section 3: respiratory system, vol 4: gas exchange. American Physiological Society, Bethesda, pp 199–215

    Google Scholar 

  5. Farhi LE, Rahn H (1955) A theoretical analysis of the alveolar-arterial O2 difference with special reference to the distribution effect. J Appl Physiol 7:699–703

    PubMed  CAS  Google Scholar 

  6. Glenny RW, Polissar L, Robertson HT (1991) Relative contribution of gravity to pulmonary perfusion heterogeneity. J Appl Physiol 71:2449–2552

    PubMed  CAS  Google Scholar 

  7. Hakim TS, Lisbona R, Dean GW (1987) Gravity-independent inequality in pulmonary blood flow in humans. J Appl Physiol 63:1114–1121

    PubMed  CAS  Google Scholar 

  8. Heidelberger E, Reeves RB (1990) Factors affecting whole blood O2 transfer kinetics: implications for θ (O2). J Appl Physiol 68:1865–1874

    PubMed  CAS  Google Scholar 

  9. Hlastala MP (1987) Diffusing-capacity heterogeneity. In: Farhi LE, Tenney SM (eds) Handbook of physiology, section 3: respiratory system, vol 4: gas exchange. American Physiological Society, Bethesda, pp 217–232

    Google Scholar 

  10. Kellogg RH (1987) Laws of physics pertaining to gas exchange. In: Farhi LE, Tenney SM (eds) Handbook of physiology, section 3: respiratory system, vol 4: gas exchange. American Physiological Society, Bethesda, pp 13–31

    Google Scholar 

  11. Meyer M, Scheid P, Riepl G, Wagner HJ, Piiper J (1981) Pulmonary diffusing capacities for O2 and CO measured by a rebreathing technique. J Appl Physiol 51:1643–1650

    PubMed  CAS  Google Scholar 

  12. Meyer M, Schuster KD, Schulz H, Mohr M, Piiper J (1990) Alveolar slope and dead space of He and SF6 in dogs: comparison of airway and venous loading. J Appl Physiol 69:937–944

    PubMed  CAS  Google Scholar 

  13. Neufeld GR, Gobran S, Baumgardner JE, Aukburg SF, Schreiner M, Scherer PW (1991) Diffusivity respiratory rate and tidal volume influence inert gas expirograms. Respir Physiol 84:31–47

    Article  PubMed  CAS  Google Scholar 

  14. Otis AB (1964) Quantitative relationships in steady-state gas exchange. In: Fenn WO, Rahn H (eds) Handbook of physiology, section 3: respiration, vol 1. American Physiological Society, Washington DC, pp 681–698

    Google Scholar 

  15. Paiva M, Engel LA (1981) The anatomical basis for the sloping alveolar plateau. Respir Physiol 44:325–337

    Article  PubMed  CAS  Google Scholar 

  16. Piiper J (1986) Blood-gas equilibrium of carbon dioxide in lungs: a continuing controversy. J Appl Physiol 60:1–8

    Article  PubMed  CAS  Google Scholar 

  17. Piiper J, Scheid P (1980) Blood-gas equilibration in lungs. In: West JB (ed) Pulmonary gas exchange, vol 1. Academic, New York, pp 131–171

    Google Scholar 

  18. Piiper J, Scheid P (1987) diffusion and convection in intrapulmonary gas mixing. In: Farhi LE, Tenney SM (eds) Handbook of physiology, section 3: respiratory system, vol 4: gas exchange. American Physiological Society, Bethesda, pp 51–69

    Google Scholar 

  19. Riley RL, Cournand A (1951) Analysis of factors affecting partial pressures of oxygen and carbon dioxide in gas and blood of the lungs: theory. J Appl Physiol 4:77–101

    PubMed  CAS  Google Scholar 

  20. Roughton FJW, Forster RE (1957) Relative importance of diffusion and chemical reaction rates in determining rate of exchange of gases in the human lung, with special reference to true differing capacity of pulmonary membrane and volume of blood in lung capillaries. J Appl Physiol 11:291–302

    Google Scholar 

  21. Scheid P, Piiper J (1989) Blood-gas equilibration in lungs and pulmonary diffusing capacity. In: Chang HK, Paiva M (eds) Respiratory physiology, an analytical approach. Dekker, New York, pp 453–497

    Google Scholar 

  22. Sheehan DW, Klocke RA, Farhi LE (1992) Pulmonary hypoxic vasoconstriction: how strong? How fast? Respir Physiol 87:357–372

    Article  PubMed  CAS  Google Scholar 

  23. Swenson ER, Maren TH (1978) A quantitative analysis of CO2 transport at rest and during maximal exercise. Respir Physiol 35:129–159

    Article  PubMed  CAS  Google Scholar 

  24. Thews G (1984) Theoretical analysis of pulmonary gas exchange at rest and during exercise. Int J Sports Med 5:113–119

    Article  PubMed  CAS  Google Scholar 

  25. Wagner PD (1977) Diffusion and chemical reaction in pulmonary gas exchange. Physiol Rev 57:257–312

    PubMed  CAS  Google Scholar 

  26. Wagner PD, Laravuso RB, Uhl RR, West JB (1974) Continuous distributions of ventilation-perfusion ratios in normal subjects breathing air and 100% O2. J Clin Invest 54:54–68

    Article  PubMed  CAS  Google Scholar 

  27. Wagner PD, Saltzman HA, West JB (1974) Measurement of continuous distributions of ventilation-perfusion ratios: theory. J Appl Physiol 36:588–599

    PubMed  CAS  Google Scholar 

  28. Weibel ER (1963) Morphometry of the human lung. Springer, Berlin Göttingen Heidelberg

    Google Scholar 

  29. Weibel ER (1973) Morphological basis of alveolar-capillary gas exchange. Physiol Rev 53:419–495

    PubMed  CAS  Google Scholar 

  30. West JB (1977) Ventilation/blood flow and gas exchange, 3rd edn. Blackwell, Oxford

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Piiper, J. (1996). Pulmonary Gas Exchange. In: Greger, R., Windhorst, U. (eds) Comprehensive Human Physiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60946-6_102

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-60946-6_102

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64619-5

  • Online ISBN: 978-3-642-60946-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics