Frameshifting in Prokaryotes and Eukaryotes
Frameshifting has been observed in several systems to date. It is used to increase the genetic content of a stretch of DNA/RNA or to produce different proteins that have related regions towards their amino termini. The efficiency of these events also determines the dosage of the alternative gene products. In this article we will describe frameshifting systems from both prokaryotes and eukaryotes. The prokaryotic systems that will be described will emphasise those frameshifting events that are involved in cellular gene expression whereas the eukaryotic examples will be from retroviruses and retrotransposons where the molecular determinants of shifting have been studied in most detail (see Jacks,1989, for a full review).
KeywordsCodon Adenosine Sarcoma Polypeptide Tryptophan
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