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Molecular Biology, Pharmacology, and Genetics of the Serotonin Transporter: Psychobiological and Clinical Implications

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Serotoninergic Neurons and 5-HT Receptors in the CNS

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 129))

Abstract

Serotonin (5-HT), which acts at multiple pre- and postsynaptic receptor sites, fulfills the criteria for a neurotransmitter and modulator of synaptic signal transduction in many functional systems of the brain. As a consequence of this enormous versatility, brainstem 5-HT systems affect many diverse functions, such as mood, cognition, appetite and satiation, sleep, motor behavior, neuroendocrine and circadian rhythms, social and reproductive behavior. By determining the magnitude and duration of postsynaptic receptor-mediated signaling, carrier-facilitated 5-HT transport into and release from the presynaptic neuron plays a key role in the spatiotemporal fine-tuning of 5-HT neurotransmission (Fig. 1). Recent advances have resulted from the molecular and functional characterization of the serotonin transporter (5-HTT), from pharmacological and neurochemical studies relating the actions of psychoactive drugs (e.g., tricyclics, selective 5-HT reuptake inhibitors, psychostimulants) to discrete effects on 5-HT uptake and release, and from the molecular dissection of the complex changes in functional expression as a consequence of altered gene transcription. On the basis of its molecular structure and anatomical distribution, substrate specificity, electrophysiological properties, and drug-binding profiles the 5-HTT has been placed in the extended gene family of Na+/C1--dependent cell surface transport proteins.

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References

  • Altemus M, Murphy DL, Greenberg B, Lesch KP (1996) Intact coding region of the serotonin transporter in obsessive-compulsive disorder. Am J Med Genet 67: 409–411

    Article  PubMed  CAS  Google Scholar 

  • Amara S, Kuhar M (1993) Neurotransmitter transporters: recent progress. Annu Rev Neurosci 16: 73–93

    Article  PubMed  CAS  Google Scholar 

  • Andrews AM, Murphy DL (1993) 2’-NH2-MPTP in Swiss Webster mice: evidence for long-term (6-month) depletion in cortical and hippocampal serotonin and norepinephrine, differential protection by selective uptake inhibitors or clorgyline and functional changes in central serotonin transmission. J Pharmacol Exp Therap 267: 1432–1439

    CAS  Google Scholar 

  • Arora RC, Meltzer HY (1986) Effect of adrenalectomy and corticosterone on [3H]imipramine binding in rat blood platelets and brain. Eur J Pharmacol 123: 415–419

    Article  PubMed  CAS  Google Scholar 

  • Barker EL, Blakely RD (1995) Norepinephrine and serotonin transporters: molecular targets of antidepressant drugs. In: Bloom FE, Kupfer DJ (eds) Psychopharmacology: the fourth generation of progress. Raven, New York, pp 321–333

    Google Scholar 

  • Barker EL, Kimmel HL, Blakely RD (1994) Chimeric human and rat serotonin transporters reveal domains involved in recognition of transporter ligands. Mol Pharmacol 46: 799–807

    PubMed  CAS  Google Scholar 

  • Bengel D, Heils A, Petri S, Teufel A, Seemann M, Riederer P, Murphy DL, Lesch KP (1997) Gene structure and 5′-flanking regulatory region of the murine serotonin transporter. Brain Res Mol Brain Res 44: 286–293

    Article  PubMed  CAS  Google Scholar 

  • Bengel D, Murphy DL, Feltner D, Seemann M, Heils A, Grinberg A, Westphal H, Lesch KP (1997) Targeted disruption of the murine serotonin transporter gene. Proc Natl Acad Sci USA (submitted)

    Google Scholar 

  • Blakely RD, Berson HE, Fremeau RT, Caron MC, Peek MM, Prince HK, Bradley CC (1991) Cloning and expression of functional serotonin transporter from rat brain. Nature 354: 66–70

    Article  PubMed  CAS  Google Scholar 

  • Blakely R, De Felice LJ, Hartzell HC (1994) Molecular physiology of norepinephrine and serotonin transporters. J Exp Biol 196: 263–281

    PubMed  CAS  Google Scholar 

  • Blier P, De Montigny C, Chaput Y (1990) A role for the serotonin system in the mechanisms of action of antidepressant treatments: preclinical evidence. J Clin Psychiatry 51S: 14–20

    Google Scholar 

  • Bouchard TJ Jr (1994) Genes, environment and personality. Science 264: 1700–1701

    Article  PubMed  Google Scholar 

  • Briley MS, Langer SZ, Raiman R, Sechter D, Zarifian E (1980) Tritiated imipramine binding sites are decreased in platelets of untreated depressed patients. Science 209: 303–305

    Article  PubMed  CAS  Google Scholar 

  • Buckman TD, Chang R, Sutphin MS, Eiduson S (1988) Interaction of 1-methyl-4-phenylpyridinium ion with human platelets. Biochem Biophys Res Commun 151: 897–904

    Article  PubMed  CAS  Google Scholar 

  • Bustin, SA, McKay IA (1994) Transcription factors: targets for new designer drugs. Br J Biomed Sci 51: 157–157

    Google Scholar 

  • Chang AS, Chang S, Starnes DM (1993) Structure-activity relationships of serotonin transport: relevance to nontricyclic antidepressant interactions. Eur J Pharmacol 247: 239–248

    Article  PubMed  CAS  Google Scholar 

  • Cloninger CR (1987) Neurogenetic adaptive mechanisms in alcoholism. Science 236: 410–416

    Article  PubMed  CAS  Google Scholar 

  • Collier DA, Arranz MJ, Sham P, Battersby S, Wallada H, Gill P, Aitchison KJ, Sodhi M, Li T, Roberts GW, Smith B, Morton J, Murray RM, Smith D, Kirov G (1996a) The serotonin transporter is a potential susceptibility factor for bipolar affective disorder. Neuroreport 7: 1675–1679

    Article  PubMed  CAS  Google Scholar 

  • Collier DA, Stöber G, Li T, Heils A, Catalano M, Di Bella D, Arranz MJ, Murray RM, Vallada HP, Bengel D, Müller CR, Roberts GW, Smeraldi E, Kirov G, Pak S, Lesch KP (1996b) A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Mol Psychiatry 1: 453–460

    PubMed  CAS  Google Scholar 

  • Corey JL, Quick MW, Davidson N, Lester HA, Guastella J (1994) A cocaine-sensitive Drosophila serotonin transporter: cloning, expression, and electrophysiological characterization. Proc Natl Acad Sci USA 91: 1188–1192

    Article  PubMed  CAS  Google Scholar 

  • Cortes R, Soriano E, Pazos A, Probst A, Palacios JM (1988) Autoradiography of antidepressant binding sites in the human brain: localization using [3H]imipramine and [3H]paroxetine. Neuroscience 27: 473–496

    Article  PubMed  CAS  Google Scholar 

  • Dave V, Kimelberg HK (1994) Na+-dependent, fluoxetine-sensitive serotonin uptake by astrocytes tissue-printed from rat cerebral cortex. J Neurosci 14: 4972–4986

    PubMed  CAS  Google Scholar 

  • Davies, HML, Kuhn LA, Thornley C, Matasi JJ, Sexton T, Childers SR (1996) Synthesis of 3β-aryl-8-azabicyclo-(31)-octanes with high binding affinities and selectivities for the serotonin transporter site. J Med Chem 39: 2554–2558

    Article  PubMed  CAS  Google Scholar 

  • Demchyshyn LL, Pristupa B, Sugamori KS, Barker EL, Blakely RD, Wolfgang WJ, Forte MA, Niznik HB (1994) Cloning, expression, and localization of a chloride-facilitated, cocaine-sensitive serotonin transporter from Drosophila melanogaster. Proc Natl Acad Sci USA 91: 5158–5162

    Article  PubMed  CAS  Google Scholar 

  • Di Bella D, Catalano M, Balling U, Smeraldi E, Lesch KP (1996) Systematic screening for mutations in the coding region of the 5-HTT gene using PCR and DGGE. Am J Hum Genet 67: 541–545

    Google Scholar 

  • Ellis PM, Salmond C (1994) Imipramine binding in depression: a meta-analysis. Biol Psychiatry 36: 292–299

    Article  PubMed  CAS  Google Scholar 

  • Fumagalli F, Jones SR, Caron MG, Seidler FJ, Slotkin TA (1996) Expression of mRNA coding for the serotonin transporter in aged vs young rat brain: differential effects of glucocorticoids. Brain Res 719: 225–228

    Article  PubMed  CAS  Google Scholar 

  • Heils A, Teufel A, Petri S, Seemann M, Bengel D, Balling U, Riederer P, Lesch KP (1995) Functional promoter and polyadenylation site mapping of the human serotonin (5-HT) transporter gene. J Neural Transm 102: 247–254

    Article  CAS  Google Scholar 

  • Heils A, Teufel A, Petri S, Stöber G, Riederer P, Bengel B, Lesch KP (1996) Allelic variation of human serotonin transporter gene expression. J Neurochem 6: 2621–2624

    Google Scholar 

  • Hensler JG, Ferry RC, Labow DM, Kovachich GB, Frazer A (1994) Quantitative autoradiography of the serotonin transporter to assess the distribution of serotonergic projections from the dorsal raphe nucleus. Synapse 17: 1–15

    Article  PubMed  CAS  Google Scholar 

  • Hoffman BJ, Mezey E, Brownstein M (1991) Cloning of a serotonin transporter affected by antidepressants. Science 254: 579–580

    Article  PubMed  CAS  Google Scholar 

  • Hrdina PD, Foy B, Hepner A, Summers RJ (1989) Antidepressant binding sites in brain: autoradiographic comparison of (3H)paroxetine and (3H)imipramine localization and relationship to serotonin transporter. J Pharmacol Exp Therap 252: 410–417

    Google Scholar 

  • Ivgy-May N, Tamir H, Gershon MD (1994) Synaptic properties of serotonergic growth cones in developing rat brain. J Neurosci 14: 1011–1029

    PubMed  CAS  Google Scholar 

  • Jagust WJ, Eberling JL, Biegon A, Taylor SE, Van Brocklin HF, Jordan S, Handrahan SM, Roberts JA, Brennan KM, Mathis CA (1996) [123I]5-Iodo-6-nitroquipazine: SPECT radiotracer to image the serotonin transporter. J Nuclear Med 37: 1207–1214

    CAS  Google Scholar 

  • Jayanthi LD, Ramamoorthy S, Mahesh VB, Leibach FH, Ganapathy V (1994) Calmodulin-dependent regulation of the catalytic function of the human serotonin transporter in placental choriocarcinoma cells. J Biol Chem 269: 14424–14429

    PubMed  CAS  Google Scholar 

  • Jess U, Betz H, Schloss P (1996) The membrane bound rat serotonin transporter, SERT1, is an oligomeric protein. FEBS Lett 394: 44–46

    Article  PubMed  CAS  Google Scholar 

  • Joyce JN, Shane A, Lexow N, Winokur A, Casanova MF, Kleinman JE (1993) Serotonin uptake sites and serotonin receptors are altered in the limbic system of schizophrenics. Neuropsychopharmacology 8: 315–336

    PubMed  CAS  Google Scholar 

  • Kelsoe JR, Remick RA, Sadovnick AD, Kristbjarnarson H, Flodman P, Spence MA, Morison M, Mroczkowskiparker Z, Bergesch P, Rapaport MH, Mirow AL, Blakely RD, Helgason T, Egeland J (1996) Genetic linkage study of bipolar disorder and the serotonin transporter. Am J Med Genet 67: 215–227

    Article  PubMed  CAS  Google Scholar 

  • Kia HK, Brisorgueil MJ, Daval G, Langlois X, Hamon M, Verge D (1996) Serotonin1A receptors are expressed by a subpopulation of cholinergic neurons in the rat medial septum and diagonal band of Broca-A double immunocytochemical study. Neurosci 74: 143–154

    Article  CAS  Google Scholar 

  • Lander ES, Schork NJ (1994) Genetic dissection of complex traits. Science 265: 2037–2048

    Article  PubMed  CAS  Google Scholar 

  • Laruelle M, Abi-Dargham A, Casanova MF, Toti R, Weinberger DR, Kleinman JE (1993) Selective abnormalities of serotonergic receptors in schizophrenia: a postmortem study. Arch Gen Psychiatry 50: 810–818

    Article  PubMed  CAS  Google Scholar 

  • Launay JM, Bonduox D, Oset-Gasque MJ, Emami S, Mutel K, Haimart M, Gespach C (1994) Increases in human platelet serotonin uptake by atypical histamine receptors. Am J Physiol 266: 526–536

    Google Scholar 

  • Lebrand C, Cases O, Adelbrecht C, Doye A, Alvarez C, Elmestikawy S, Seif I, Gaspar P (1996) Transient uptake and storage of serotonin in developing thalamic neurons. Neuron 17: 823–835

    Article  PubMed  CAS  Google Scholar 

  • Lesch KP, Wolozin BL, Estler HC, Murphy DL, Riederer P (1993a) Isolation of a cDNA encoding the human brain serotonin transporter. J Neural Transm 91: 67–73

    Article  CAS  Google Scholar 

  • Lesch KP, Aulakh CS, Wolozin BL, Tolliver TJ, Hill JL, Murphy DL (1993b) Regional brain expression of serotonin transporter mRNA and its regulation by reuptake inhibiting antidepressants. Mol Brain Res 17: 31–35

    Article  PubMed  CAS  Google Scholar 

  • Lesch KP, Balling U, Gross J, Strauss K, Wolozin BL, Murphy DL, Riederer P (1994) Organization of human serotonin transporter gene. J Neural Transm 95: 157–164

    Article  CAS  Google Scholar 

  • Lesch KP, Bengel D (1995) Neurotransmitter reuptake mechanisms: targets for drugs to study and treat psychiatric, neurological and neurodegenerative disorders. CNS Drugs 4: 302–322

    Article  CAS  Google Scholar 

  • Lesch KP, Franzek E, Gross J, Wolozin BL, Riederer P, Murphy DL (1995) Primary structure of the serotonin transporter in unipolar depression and bipolar disorder. Biol Psychiatry 37: 215–223

    Article  PubMed  CAS  Google Scholar 

  • Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Müller CR, Hamer DH, Murphy DL (1996a) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274: 1527–1531

    Article  PubMed  CAS  Google Scholar 

  • Lesch KP, Heils A, Riederer P (1996b) The role of neurotransporters in excitotoxicity, neuronal cell death and other neurodegenerative processes. J Mol Med 74: 365–378

    Article  PubMed  CAS  Google Scholar 

  • Levi G, Raiteri M (1993) Carrier-mediated release of neurotransmitters. Trends Neurosci 16: 415–419

    Article  PubMed  CAS  Google Scholar 

  • Li T, Holmes C, Sham PC, Vallada H, Birkett J, Kirov G, Lesch KP, Powell J, Lovestone S, Collier D (1997) Allelic functional variation of serotonin transporter expression is a susceptibility factor for late onset Alzheimer’s disease. Neuroreport 8: 683–686

    Article  PubMed  CAS  Google Scholar 

  • Linnet K, Koed K, Wiborg O, Gregersen N (1995) Serotonin depletion decreases serotonin transporter mRNA levels in rat brain. Brain Res 697: 251–253

    Article  PubMed  CAS  Google Scholar 

  • Mager S, Min C, Henry DJ, Chavkin C, Hoffman BJ, Davidson N, Lester HA (1994) Conducting states of a mammalian serotonin transporter. Neuron 12: 845–859

    Article  PubMed  CAS  Google Scholar 

  • Mayser W, Betz H, Schloss P (1991) Isolation of cDNA encoding a novel member of the neurotransmitter transporter gene family. FEBS Lett 295: 203–206

    Article  PubMed  CAS  Google Scholar 

  • McLaughlin DP, Little KY, Lopez JF, Watson SJ (1996) Expression of serotonin transporter mRNA in human brainstem raphe nuclei. Neuropsychopharmacology 15: 523–529

    Article  PubMed  CAS  Google Scholar 

  • Meltzer H, Arora RC (1988) Genetic control of serotonin uptake in blood platelets: a twin study. Psychiatry Res 24: 263–269

    Article  PubMed  CAS  Google Scholar 

  • Miller KJ, Hoffman BJ (1994) Adenosine A3 receptors regulate serotonin transport via nitric oxide and cGMP. J Biol Chem 269: 27351–27356

    PubMed  CAS  Google Scholar 

  • Murphy DL, Mitchell PB, Potter WZ (1995) Novel pharmacological approaches to the treatment of depression. In: Bloom FE, Kupfer DJ (eds) Psychopharmacology: the fourth generation of progress. Raven, New York

    Google Scholar 

  • Nelson PJ, Rudnick G (1979) Coupling between platelet 5-hydoxytryptamine and potassium transport. J Biol Chem 254: 10084–10089

    PubMed  CAS  Google Scholar 

  • Neumaier JF, Root DC, Hamblin MW (1996a) Chronic fluoxetine reduces serotonin transporter mRNA and 5 HT1B mRNA in a secuential manner in the rat dorsal raphe nucleus. Neuropsychopharmacology 15: 515–522

    Article  PubMed  CAS  Google Scholar 

  • Neumaier JF, Szot P, Peskind ER, Dorsa DM, Hamblin MW (1996b) Serotonergic lesioning differentially affects presynaptic and postsynaptic 5-HT1B receptor mRNA levels in rat brain. Brain Res 722: 50–58

    Article  PubMed  CAS  Google Scholar 

  • Ogilvie AD, Battersby B, Bubb VJ, Fink G, Harmar AJ, Goodwin GM, Smith CAD (1996) Polymorphism in serotonin transporter gene associated with susceptibility to major depression. Lancet 347: 731–733

    Article  PubMed  CAS  Google Scholar 

  • Owen MJ, Nemeroff CB (1994) The role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Clin Chem 40: 288–295

    Google Scholar 

  • Paul S, Rehavi N, Skolnick P, Ballenger J, Goodwin F (1981) Depressed patients have decreased binding of tritiated imipramine to platelet serotonin transporter. Arch Gen Psychiatry 38: 1315–1317

    Article  PubMed  CAS  Google Scholar 

  • Peiffer A, Veilleux S, Barden N (1991) Antidepressant and other centrally acting drugs regulate glucocorticoid receptor messenger RNA levels in rat brain. Psychoneuroendocrinology 16: 505–515

    Article  PubMed  CAS  Google Scholar 

  • Pepin M, Govindan M, Barden N (1991) Increased glucocorticoid receptor gene promoter activity after antidepressant treatment. Mol Pharmacol 41: 1016–1022

    Google Scholar 

  • Pineyro G, Blier P, Dennis T, De Montigny C (1994) Desensitization of the neuronal 5-HT carrier following its long-term blockade. J Neurosci 14: 3036–3047

    PubMed  CAS  Google Scholar 

  • Piven J, Tsai G, Nehme E, Coyle JT, Chase GA, Folstein SE (1991) Platelet serotonin, a possible marker for familial autism. J Autism Develop Disord 21: 51–59

    Article  CAS  Google Scholar 

  • Qian Y, Melikian HE, Rye DB, Levey AI, Blakely RD (1995) Identification and characterization of antidepressant-sensitive serotonin transporter proteins using site-specific antibodies. J Neurosci 15: 1261–1274

    PubMed  CAS  Google Scholar 

  • Ramamoorthy S, Bauman A, Moore K, Han H, Yang-Feng T, Chang A, Ganapathy V, Blakely R (1993) Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. Proc Natl Acad Sci USA 90: 2542–2546

    Article  PubMed  CAS  Google Scholar 

  • Ramamoorthy S, Ramamoorthy JD, Prasad PD, Bhat GK, Mahesh VB, Leibach FH, Ganapathy V (1995) Regulation of the human serotonin transporter by interleukin-1 beta. Biochem Biophys Res Commun 216: 560–567

    Article  PubMed  CAS  Google Scholar 

  • Rattray M, Wotherspoon G, Savery D, Baldessari S, Marden C, Priestley JV, Bendotti C (1994) Chronic D-fenfluramine decreases serotonin transporter messenger RNA expression in dorsal raphe nucleus. Eur J Pharmacol Mol Pharmacol 268: 439–442

    Article  CAS  Google Scholar 

  • Rattray M, Baldessari S, Gobbi M, Mennini T, Saminin R, Bendotti C (1996) p-Chlorphenylalanine changes serotonin transporter mRNA levels and expression of the gene product. J Neurochem 67: 463–472

    Article  PubMed  CAS  Google Scholar 

  • Routledge C, Middlemiss DN (1996) The 5-HT hypothesis of depression revisited. Mol Psychiatry 1: 437

    PubMed  CAS  Google Scholar 

  • Rudnick G, Wall SC (1993) Non-neurotoxic amphetamine derivatives release serotonin through serotonin transporters. Mol Pharmacol 43: 271–276

    PubMed  CAS  Google Scholar 

  • Sander T, Harms H, Dufeu P, Kuhn S, Hoehe M, Lesch KP, Schmidt LG (1997) Serotonin transporter gene variants and type-2 alcohol dependence. Biol Psychiatry (in press)

    Google Scholar 

  • Schloss P, Betz H (1995) Heterogeneity of antidepressant binding sites on the recombinant rat serotonin transporter SERT1. Biochemistry 34: 12590–12595

    Article  PubMed  CAS  Google Scholar 

  • Schuldiner S, Steiner-Mordoch S, Yelin R, Wall SC, Rudnick G (1993) Amphetamine derivatives interact with both plasma membrane and secretory vesicle biogenic amine transporters. Mol Pharmacol 44: 1227–1231

    PubMed  CAS  Google Scholar 

  • Semple-Rowland SL, Mahatme A, Rowland NE (1996) Effects of dexfenfluramine or 5, 7-dihydroxytryptamine on tryptophan hydroxylase and serotonin transporter mRNAs in rat dorsal raphe. Mol Brain Res 41: 121–127

    Article  PubMed  CAS  Google Scholar 

  • Slotkin TA, Barnes GA, McCook EC, Seidler FJ (1996a) Programming of brainstem serotonin transporter development by prenatal glucocorticoids. Dev Brain Res 93: 155–161

    Article  CAS  Google Scholar 

  • Slotkin TA, McCook EC, Ritchie JC, Seidler FJ (1996b) Do glucocorticoids contribute to the abnormalities in serotonin transporter expression and function seen in depression: an animal model. Biol Psychiatry 40: 576–584

    Article  PubMed  CAS  Google Scholar 

  • Sonders MS, Amara SG (1996) Channels in transporters. Curr Opin Neurobiol 6: 294–302

    Article  PubMed  CAS  Google Scholar 

  • Staley JK, Basile M, Flynn DD, Mash DC (1994) Visualizing dopamine and serotonin transporters in the human brain with the potent cocaine analogue. J Neurochem 62: 549–556

    Article  PubMed  CAS  Google Scholar 

  • Stanley M, Virgilio J, Gershon S (1982) Tritiated imipramine binding sites are decreased in the frontal cortex of suicides. Science 216: 1337–1339

    Article  PubMed  CAS  Google Scholar 

  • Stöber G, Heils A, Lesch KP (1996) Serotonin transporter gene polymorphism and affective disorder. Lancet 347: 1340–1341

    Article  PubMed  Google Scholar 

  • Stockmeier CA, Shapiro LA, Haycock JW, Thompson PA, Lowy MT (1996) Quantitative subregional distribution of serotonin (1A) receptors and serotonin transporters in the human dorsal raphe. Brain Res 727: 1–12

    Article  PubMed  CAS  Google Scholar 

  • Sur C, Betz H, Schloss P (1996) Immunocytochemical detection of the serotonin transporter in rat brain. Neurosci 73: 217–231

    Article  CAS  Google Scholar 

  • Toth M, Shenk T (1994) Antagonist-mediated down-regulation of 5-hydroxytryptamine type 2 receptor gene expression: modulation of transcription. Mol Pharmacol 45: 1095–1100

    PubMed  CAS  Google Scholar 

  • Tukiainen E (1981) Effect of hypophysectomy and adrenalectomy on 5-hydroxytryptamine uptake by rat hypothalamic synaptosomes and blood platelets. Acta Pharmacol Toxicol 48: 139–143

    Article  CAS  Google Scholar 

  • Uhl GR, Johnson PS (1994) Neurotransmitter transporters: three important gene families for neuronal function. J Exp Biol 196: 229–236

    PubMed  CAS  Google Scholar 

  • Wall SC, Gu H, Rudnick G (1995) Biogenic amine flux mediated by cloned transporters stably expressed in cultured cell lines: amphetamine specificity for inhibition and efflux. Mol Pharmacol 47: 544–550

    PubMed  CAS  Google Scholar 

  • Yu A, Yang J, Pawlyk AC, Tejani-Butt SM (1995) Acute depletion of serotonin down-regulates serotonin transporter mRNA in raphe neurons. Brain Res 688: 209–212

    Article  PubMed  CAS  Google Scholar 

  • Zhou D, Huether G, Wiltfang J, Hajak G, Rüther E (1996) Serotonin transporters in the rat frontal cortex: lack of circadian rhythmicity but down-regulation by food restriction. J Neurochem 67: 656–661

    Article  PubMed  CAS  Google Scholar 

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  1. K.-P. Lesch
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Editors and Affiliations

  1. Freie Universität Berlin, Institut für Anatomie, Königin-Luise-Str. 15, 14195, Berlin, Germany

    H. G. Baumgarten M.D.

  2. Rheinische Friedrich-Wilhelms-Universität Bonn, Institut für Pharmakologie und Toxikologie, Reuterstr. 2b, 53113, Bonn, Germany

    M. Göthert

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Lesch, KP. (2000). Molecular Biology, Pharmacology, and Genetics of the Serotonin Transporter: Psychobiological and Clinical Implications. In: Baumgarten, H.G., Göthert, M. (eds) Serotoninergic Neurons and 5-HT Receptors in the CNS. Handbook of Experimental Pharmacology, vol 129. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60921-3_26

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  • DOI: https://doi.org/10.1007/978-3-642-60921-3_26

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