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Neuroendocrinology pp 43–54Cite as

Components of the Neuroendocrine Exocytosis Apparatus

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Abstract

Exocytosis by neurons and permeabilized endocrine cells is inhibited by clostridial neurotoxins. This observation suggested that the mechanism of exocytosis is similar in both cell types although the process by which the neurotoxins gain access to the cell interior may be different. The present contribution summarizes the basic observations which led to the identification of the targets of the neurotoxins shared by neurons and endocrine cells. Furthermore, the probable function of the interaction of the identified membrane proteins synaptobrevin, synaptosome associated protein of 25 kDa (SNAP-25) and syntaxin in endocrine cells and the possible role of the calcium binding synaptotagmin and of the N-ethylmaleimide sensitive factor (NSF) and soluble NSF attachment proteins (SNAPs) is discussed.

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  1. Anatomisches Institut der Technischen, Universität München, Biedersteiner Straße 29, D-80802, München, Germany

    M. Gratzl & B. Höhne-Zell

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  1. M. Gratzl
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  2. B. Höhne-Zell
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  1. Dr. Senckenbergische Anatomie, Klinikum der J.W. Goethe-Universität, Theodor-Stern-Kai 7, D-60590, Frankfurt/Main, Germany

    Horst-Werner Korf

  2. Medizinische Klinik I, Klinikum der J.W. Goethe-Universität, Theodor-Stern-Kai 7, D-60590, Frankfurt/Main, Germany

    Klaus-Henning Usadel

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Gratzl, M., Höhne-Zell, B. (1997). Components of the Neuroendocrine Exocytosis Apparatus. In: Korf, HW., Usadel, KH. (eds) Neuroendocrinology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60915-2_4

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