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Mechanisms of Neuronal Migration

  • Conference paper
Normal and Abnormal Development of the Cortex

Part of the book series: Research and Perspectives in Neurosciences ((NEUROSCIENCE))

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Abstract

The migration of neuronal precursors from germinal zones to neuronal layers is critical to the establishment of functional neural circuitry in developing brain. Previous work has identified a protein, astrotactin (ASTN), as the neuronal ligand for locomotion along the radial glial fiber system. Molecular cloning of astrotactin reveals that the molecule is a membrane associated glycoprotein with three EGF motifs and two FNIII domains. As shown by in vitro studies, the expressed bacterial fusion protein functions in neuronal migration, suggesting that astrotactin provides a mechanism for glia-guided migration. Genetic analyses indicate that the gene is located on Chromosome 1 in the mouse, in a region syntenic with lq25-27 in humans. Mutations in this area of the human genome are associated with microcephaly and other developmental anomalies.

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Authors
  1. C. Zheng
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  2. E. Ross
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  3. J. Alder
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  4. M. Hofer
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  5. J. Millonig
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  6. K. Millen
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  7. P. Kofuji
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  8. N. Davidson
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  9. H. Lester
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  10. N. Heintz
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  11. M. E. Hatten
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Editor information

Editors and Affiliations

  1. Beth Israel Deaconess Medical Center, East Campus, 330 Brookline Avenue, 02215, Boston, MA, USA

    A. M. Galaburda M.D.

  2. Fondation IPSEN, 24 rue Erlanger, 75781, Paris Cédex 16, France

    Y. Christen Ph.D.

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© 1997 Springer Verlag Berlin Heidelberg

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Zheng, C. et al. (1997). Mechanisms of Neuronal Migration. In: Galaburda, A.M., Christen, Y. (eds) Normal and Abnormal Development of the Cortex. Research and Perspectives in Neurosciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60861-2_3

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  • DOI: https://doi.org/10.1007/978-3-642-60861-2_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64590-7

  • Online ISBN: 978-3-642-60861-2

  • eBook Packages: Springer Book Archive

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