The Constitutive Activation of MET, RON and SEA Genes Induces Different Biological Responses

  • Massimo Mattia Santoro
  • Giovanni Gaudino
Conference paper
Part of the NATO ASI Series book series (volume 102)

Abstract

The MET proto-oncogene, encoding the Hepatocyte Growth Factor receptor, is the prototype of a gene family encoding structurally homologous heterodimeric tyrosine kinase receptors, including human RON (19) and avian SEA (8). It can be converted into an oncogene by rearrangement of the kinase domain with a N-terminal unrelated sequence designated TPR (3). The kinase activity of the encoded hybrid protein (Tpr-Met) is deregulated, since two leucine-zipper motifs present in the Tpr moiety promote its constitutive dimerization (18). This conformation mimics receptor activation following ligand binding.

Keywords

Migration Tyrosine Sarcoma Leucine Polycarbonate 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Massimo Mattia Santoro
    • 1
  • Giovanni Gaudino
    • 1
  1. 1.Department of Science & Advanced TechnologiesUniversity of TorinoAlessandriaItaly

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