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Regulation of p70s6k

  • Conference paper
Interacting Protein Domains

Part of the book series: NATO ASI Series ((ASIH,volume 102))

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Abstract

This manuscript represents the first of two lectures concerning the p70s6k and translation. It is presented as closely as possible to the actual talk.

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Key References

  1. Ferrari, S. and Thomas, G. 1994. S6 phosphorylation and the p70s6k/P85s6k. Critical Reviews in Biochem. and Mol. Biol. 29, 385 - 413.

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  2. Pearson, R. B., Dennis, P. B., Han, J-W., Williamson, N. A., Kozma, S. C., Wettenhall, R. E. H. and Thomas, G. 1995. The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain. EMBO J. 21, 5279 - 5287.

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  3. Weng, Q. P., Andrabi, K., Kozlowski, M. T., Grove, J. R. and Avruch, J. 1995. Multiple independent inputs are required for activation of the p70 S6 kinase. Mol. Cell. Biol. 15, 2333 - 2340.

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  4. Chou, M. M. and Blenis, J. 1996. The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins cdc42 and rac1. Cell 85, 573 - 583.

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  5. Dennis, P. B., Pollen, N., Kozma, S. C. and Thomas, G. 1996. The principal rapamycin- sensitive p70s6k phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases. Mol, and Cell. Biol. 16, 6242 - 6251.

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Author information

Authors and Affiliations

  1. Friedrich Miescher-Institut, Maulbeerstrasse 66, 4058, Basel, Switzerland

    Patrick B. Dennis & George Thomas

Authors
  1. Patrick B. Dennis
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  2. George Thomas
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Editor information

Editors and Affiliations

  1. Institut für Physiologische Chemie Abt. Biochemie Supramolekularer Systeme, Ruhr-Universität Bochum, D-44780, Bochum, Germany

    Ludwig Heilmeyer

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© 1997 Springer-Verlag Berlin Heidelberg

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Dennis, P.B., Thomas, G. (1997). Regulation of p70s6k . In: Heilmeyer, L. (eds) Interacting Protein Domains. NATO ASI Series, vol 102. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60848-3_27

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  • DOI: https://doi.org/10.1007/978-3-642-60848-3_27

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64583-9

  • Online ISBN: 978-3-642-60848-3

  • eBook Packages: Springer Book Archive

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