Abstract
The MAPK cascade has emerged as an evolutionarily conserved element in the transduction of a wide variety of extracellular signals. In mammals, at least three distinct pathways have been identified. These include p42 and p44 ERKs, activated by growth factors and many other mitogenic stimuli; p54 and p46 ERKs, strongly activated by stressful stimuli such as cytokines, UV radiation, and protein synthesis inhibitors; and p38 MAPKs, which are also responsive to stress-related stimuli (1).
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© 1997 Springer-Verlag Berlin Heidelberg
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Holland, P.M., Cooper, J.A. (1997). Identification and Characterization of MKKX, a novel mammalian MAP kinase kinase. In: Heilmeyer, L. (eds) Interacting Protein Domains. NATO ASI Series, vol 102. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60848-3_24
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DOI: https://doi.org/10.1007/978-3-642-60848-3_24
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