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Molecular Mechanisms of Signalling and Membrane Transport pp 233–245Cite as

The structure, biosynthesis and function of GPI membrane anchors

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Part of the book series: NATO ASI Series ((ASIH,volume 101))

Abstract

Glycosyl-phosphatidylinositol (GPI) membrane anchors are present in organisms at most stages of eukaryotic evolution, including protozoa, yeast, slime moulds, invertebrates and vertebrates, and are found on a diverse range of proteins. They are primarily responsible for the anchoring of cell-surface proteins in the plasma membrane (or in some cases to the topologically equivalent lumenal surface of secretory vesicles) and may be considered as an alternative to the hydrophobic transmembrane polypeptide anchor of type-1 integral membrane proteins (Fig. 1).

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  1. Department of Biochemistry, University of Dundee, Dundee, DD1 4HN, UK

    Michael A. J. Ferguson

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  1. Centre for Biomembranes and Lipid Enzymology, Utrecht University, Padualaan 8, 3584 TB, Utrecht, The Netherlands

    Karel W. A. Wirtz

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Ferguson, M.A.J. (1997). The structure, biosynthesis and function of GPI membrane anchors. In: Wirtz, K.W.A. (eds) Molecular Mechanisms of Signalling and Membrane Transport. NATO ASI Series, vol 101. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60799-8_17

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