The roles of PI3Ks in cellular regulation
The term phosphoinositide 30H kinase (PI3K) is given to a family of enzymes which can phosphorylate one or more of the conventional inositol phospholipids found in cells in the 3-position of their inositol headgroup (Fig. 1). It is now clear that these lipids act as regulators of intracellular metabolism and at least one of them, PtdIns(3,4,5)P3, shows all the credentials of being a major ‘second-messenger’ in signalling pathways used by cell-surface receptors for growth factors, inflammatory stimuli and antigens (Stephens et al., 1993; Cantley et al., 1991).
KeywordsTyrosine Superoxide Serine Histamine Thrombin
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