The roles of PI3Ks in cellular regulation

  • A. Eguinoa
  • S. Krugmann
  • J. Coadwell
  • L. Stephens
  • P. Hawkins
Conference paper
Part of the NATO ASI Series book series (volume 101)

Abstract

The term phosphoinositide 30H kinase (PI3K) is given to a family of enzymes which can phosphorylate one or more of the conventional inositol phospholipids found in cells in the 3-position of their inositol headgroup (Fig. 1). It is now clear that these lipids act as regulators of intracellular metabolism and at least one of them, PtdIns(3,4,5)P3, shows all the credentials of being a major ‘second-messenger’ in signalling pathways used by cell-surface receptors for growth factors, inflammatory stimuli and antigens (Stephens et al., 1993; Cantley et al., 1991).

Keywords

Tyrosine Superoxide Serine Histamine Thrombin 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Arcaro A, Wymann MP (1993) Biochem J 296:297–301PubMedGoogle Scholar
  2. Akimoto K, Takahashi, Moriya S, Nishioka N et al. (1996) EMBO J 15:788–798PubMedGoogle Scholar
  3. Antonetti, Algenstaedt P, Kahn CR (1996) Mol Cell Biol 16:2195–2203PubMedGoogle Scholar
  4. Auger KR, Serunian LA, Soltoff SP, Libby P, Cantley LC (1989) Cell 57:167–175PubMedCrossRefGoogle Scholar
  5. Backer JM, Myers MG, Shelson SE, Chin DJ, Sun X-J, Miralpeix M, Hu P, Margolis B, Skolnik Y, Schlessinger J, White MF (1992) EMBO 11:3469–3479Google Scholar
  6. Bonser RW, Thompson NT, Randall RW, Tateson JE, Spacey GD, Hodson HF, Garland LG (1991) Br. J. Pharmacol. 103:1237–1241PubMedGoogle Scholar
  7. Burgering BMT, Coffer PJ (1995) Nature 376:599–602PubMedCrossRefGoogle Scholar
  8. Cantley LC, Auger KR, Carpenter C, Duckworth B, Graziani A, Kapeller R, Soltoff S (1991) Cell 64:281–302PubMedCrossRefGoogle Scholar
  9. Carpenter CL, Auger KR, Chaudhuri M, Yoakim M, Schaffhausen B, Schoelson S, Cantley LC (1993) J Biol Chem 268:9478–9483PubMedGoogle Scholar
  10. Cheatham B, Vlahos CJ, Cheatham L, Wang L, Blenis J, Kahn CR (1994) Mol Cell Biol 14:4902–4911PubMedGoogle Scholar
  11. Chou MM, Blenis J (1996) Cell 85:573–583PubMedCrossRefGoogle Scholar
  12. Chung J, Grammar TC, Lemon KP, Kazlanskas A, Blenis J (1994) Nature 370:71–75PubMedCrossRefGoogle Scholar
  13. Cross DAE, Alessi DR, Vandenheede JR, McDowell HE, Hundal HS, Cohen P (1994) Biochem J 303:21–26PubMedGoogle Scholar
  14. Cross DAE, Alessi DR, Cohen P, Andjelkonich M, Hemmings BGA (1995) Nature 378:785–789PubMedCrossRefGoogle Scholar
  15. Dhand R, Hiles I, Panayotou G, Roche S, Fry MJ, Gout I et al. (1994) EMBO J 13:522–533PubMedGoogle Scholar
  16. Escobedo J, Navankasattusas S, Kavanaugh WN, Milfay D, Fried VA, Williams LT (1991) Cell 65:75–82PubMedCrossRefGoogle Scholar
  17. Fantl W, Escobedo JA, Martin GA, Turck CW, del Rosario M, McCormick F et al. (1992) Cell 69:413–423PubMedCrossRefGoogle Scholar
  18. Franke TF, Yang S-I, Chan TO, Datta K, Kazlauskas A, Morrison DK, Kaplan DR, Tsichlis PN (1995) Cell 81:727–736PubMedCrossRefGoogle Scholar
  19. Hara K, Yonezawa K, Sakane H, Ando A, Kotanyk et al. (1994) Proc Natl Acad Sci 91:7415–7419PubMedCrossRefGoogle Scholar
  20. Hawkins PT, Jackson TR, Stephens LR (1992) Nature 358:157–159PubMedCrossRefGoogle Scholar
  21. Hawkins PT, Eguinoa A, Qiu R-G, Stokoe D, Cooke FT, Walters R, Wennström S, Claesson-Welsh L, Evans T, Symons M, Stephens L (1995) Current Biology 5:393–403PubMedCrossRefGoogle Scholar
  22. Hiles I, Otsu M, Volinia S, Fry MJ, Gout I, Dhand R et al. (1992) Cell 70:419–429PubMedCrossRefGoogle Scholar
  23. Hu P, Mondino A, Skolnik EY, Schlessinger J (1993) Mol Cell Biol 13:7677–7688PubMedGoogle Scholar
  24. Inukai K, Anai M, Van Breda EV, Hosaka T, Katagiri H, Funaki M et al (1996) J Biol chem 271:5317–5320PubMedCrossRefGoogle Scholar
  25. Jackson TR, Blader IJ, Hammonds-Odie LP, Bunga CR, Cooke F et al (1996) J Cell Science 109:289–300PubMedGoogle Scholar
  26. James SR, Downes CP, Gigg R, Grove SJA, Holmes AB, Alessi DR (1996) Biochim J 315:709–713Google Scholar
  27. Joly M, Kazlauskas A, Fay FS, Corvera S (1994) Science 263:684–687PubMedCrossRefGoogle Scholar
  28. Kashishian A, Kazlauskas A, Cooper JA (1992) EMBO J 11:1373–1382PubMedGoogle Scholar
  29. Kimura K, Hattori S, Kakuyama Y, Shizawa Y, Takayanugi J et al (1994) J Biol Chem 269:18961–18967.PubMedGoogle Scholar
  30. Klippel A, Reinhard CW, Kavanaugh M, Apell G, Escobedo MA, Williams LT (1996) Mol Cell Biol 16:4117–4127PubMedGoogle Scholar
  31. Kotani K, Yonezawa K, Hara K, Ueda H, Kitamura Y, Sakaune H et al. (1994) EMBO J 13:2313–2321PubMedGoogle Scholar
  32. Kundra V, Escobedo J, Kazlauskas H, Lin K, Phee SG, Williams L, Zetter BR (1994) Nature 367:474–476PubMedCrossRefGoogle Scholar
  33. Li G, D’Souza-Schorey, Barbieri MA, Roberts RL, Klippel A, Williams L, Stahl PD (1995) Proc Natl Acad Sci 92:10207–10211PubMedCrossRefGoogle Scholar
  34. MacDougall LK, Domin J, Waterfield MD (1995) Current Biology 5:1405–1414CrossRefGoogle Scholar
  35. Molz L, Chen Y-W, Hirano M, Williams LT (1996) J Biol Chem 271: 13892–13899PubMedCrossRefGoogle Scholar
  36. Nakanishi H, Brewer KA, Exton JH (1993) J Biol Chem 268:13–16PubMedGoogle Scholar
  37. Okada T, Kawano Y, Sakakibara T, Hazeki O, Ui M (1994) J Biol Chem 269:3568–3573PubMedGoogle Scholar
  38. Otsu M, Hiles I, Gout I, Fry MJ, Ruiz-Larrea F, Panayotou G et al. (1991) Cell 65:91–104PubMedCrossRefGoogle Scholar
  39. Palmer RH, Dekker LV, Woscholski R, LeGood A, Gigg R, Parker PJ (1995) J Biol Chem 270:22412–22416PubMedCrossRefGoogle Scholar
  40. Pons S, Asano T, Glasheen E, Miralpeix M, Zhang Y, Fisher TL et al. (1995) Mol Cell Biol 15:4453–4465PubMedGoogle Scholar
  41. Price LS, Norman JC, Ridley AJ, Koffer A (1995) Current Biology 5:68–73PubMedCrossRefGoogle Scholar
  42. Qiu RG, Chen J, Kirn D, McCormick F, Symons M (1995) Nature 374:457–459PubMedCrossRefGoogle Scholar
  43. Rameh LE, Chen CS, Cantley LC (1995) Cell 83:821–830PubMedCrossRefGoogle Scholar
  44. Ridley A, Paterson HF, Johnston CL, Diekman D, Hall A (1992) Cell 70:401–410PubMedCrossRefGoogle Scholar
  45. Rodriguez-Viciana P, Warne PH, Dhand R, Vanhaesebroeck B, Gout I, Fry MJ, Waterfield M, Downward J (1994) Nature 370:527–532PubMedCrossRefGoogle Scholar
  46. Rodriguez-Viciana P, Warne PH, Vanhaesebroeck B, Waterfield MD, Downward J (1996) EMBO J 15:2442–2451PubMedGoogle Scholar
  47. Schlessinger J, Ullrich A (1992) Neuron 9:383–391PubMedCrossRefGoogle Scholar
  48. Schu PV, Takegawa K, Fry M, Stack JH, Waterfield MD, Emr SD (1993) Science 260:88–91PubMedCrossRefGoogle Scholar
  49. Segal AW, Abo A (1993) Trend Biochem Sci 18:43–47PubMedCrossRefGoogle Scholar
  50. Shaw (1996) BioEssays 18:35–46PubMedCrossRefGoogle Scholar
  51. Shepherd PR, Nave BT, Siddle K (1995) Biochem J 305:25–28PubMedGoogle Scholar
  52. Skolnik EY, Margolis B, Mohammadi M, Lowenstein E, Fischer R, Drepps A et al. (1991) Cell 65:83–90PubMedCrossRefGoogle Scholar
  53. Songyang Z, Shoelson SE, Chaudhuri M, Gish G, Pawson T, Haswer WG et al. (1993) Cell 72:767–778PubMedCrossRefGoogle Scholar
  54. Stephens LR, Hughes KT, Irvine RF (1991) Nature 351:33–39PubMedCrossRefGoogle Scholar
  55. Stephens L (1995) Biochem Soc Trans 23:207–221PubMedGoogle Scholar
  56. Stephens LR, Eguinoa A, Erdjument-Bromage H, Lui M, Cooke F, Coadwell J, Smrcka A, Thelen M, Cadwallader K, Tempst P, Hawkins PT (1996) SubmittedGoogle Scholar
  57. Stephens L, Smrcka A, Cooke FT, Jackson TR, Sternweis PC, Hawkins PT (1994) Cell 77:83–93PubMedCrossRefGoogle Scholar
  58. Stephens L, Cooke FT, Walters R, Jackson T, Volinia S, Gout I, Waterfield MD, Hawkins PT (1994b) Curr Biol 4:203–214PubMedCrossRefGoogle Scholar
  59. Stephens L, Jackson TJ, Hawkins PT (1993) Biochim Biophys Acta 1179:27–75PubMedCrossRefGoogle Scholar
  60. Stephens L, Eguinoa A, Corey S, Jackson TJ, Hawkins PT (1993b) EMBO J 12:2265–2273PubMedGoogle Scholar
  61. Stoyanov B, Volinia S, Hanck T, Rubio I, Loubtchenkov M, Malek D et al. (1995) Science 269:690–693PubMedCrossRefGoogle Scholar
  62. Thomason PA, James SR, Casey PJ, Downes CP (1994) J Biol Chem 269:16525–16528PubMedGoogle Scholar
  63. Toker A, Meyer M, Reddy KK, Falck JR, Aneja R, Aneja S, Parra A, Burns DJ, Ballas LM, Cantley LC (1994) J Biol Chem 269:32358–32367PubMedGoogle Scholar
  64. Traynor-Kaplan AE, Thompson BL, Harris AL, Taylor P, Omann GM, Sklar LA (1989) J Biol Chem. 264:15668–157673PubMedGoogle Scholar
  65. Valius M, Kazlaukas A (1993) Cell 73:321–334PubMedCrossRefGoogle Scholar
  66. Virbasius JV, Guilherme A, Czech MP (1996) J Biol Chem 271:13304–13307PubMedCrossRefGoogle Scholar
  67. Vlahos CJ, Matter WF, Hui KY, Brown RF (1994) J Biol Chem 269:5241–5248PubMedGoogle Scholar
  68. Volinia S, Dhand R, Vanhaesebroeck B, MacDougall LK, Stein R, Zvelebil MJ et al. (1995) EMBO J 14:3339–3348PubMedGoogle Scholar
  69. Wennström S, Hawkins P, Cooke F, Hara K, Yonezawa K, Kasuga M, Jackson T, Claesson-Welsh L, Stephens L (1994) Current Biology 4:385–393PubMedCrossRefGoogle Scholar
  70. Whitman M, Downes CP, Keeler M, Keller T, Cantley L (1988) Nature 332:644–646PubMedCrossRefGoogle Scholar
  71. Yamamoto-Honda R, Tobe K, Kaburagi Y, Ueki K et al. (1995) J Biol Chem 270:2729–2734PubMedCrossRefGoogle Scholar
  72. Yamauchi K, Holt K, Pessin JE (1993) J Biol Chem 268:14597–14600PubMedGoogle Scholar
  73. Yan H, Nakanishi S, Kimura K, Hanni N, Saitoh Y, Fukui Y, Novomura Y, Matsuda Y (1993) J Biol Chem 268:25846–25856Google Scholar
  74. Zhang J, Falck JR, Reddy KK, Abrams CS, Zhao W, Rittenhouse SE (1995) J Biol Chem 270:22807–22810PubMedCrossRefGoogle Scholar
  75. Zhang J, Zhang J, Shattil SJ, Cunningham MC, Rittenhouse SE (1996) J Biol Chem 271:6265–6272PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • A. Eguinoa
    • 1
  • S. Krugmann
    • 1
  • J. Coadwell
    • 1
  • L. Stephens
    • 1
  • P. Hawkins
    • 1
  1. 1.Signalling DepartmentThe Babraham InstituteBabraham CambridgeUK

Personalised recommendations