Urinary Trypsinogen-2 Test Strip — A New Rapid Test for Acute Pancreatitis
Early diagnosis of acute pancreatitis (AP) is important, as serious complications such as fulminant organ system failure and pancreatic necrosis or sepsis occur in 20%-30% of cases. Furthermore, intensive therapy of severe AP is more likely to be effective if it can be instituted at an early stage. However, the clinical features of AP can be atypical or hard to distinguish from other acute abdominal conditions, and the diagnosis may be overlooked at the initial examination. Therefore, there is a considerable need for a rapid and reliable test which can differentiate between AP and other abdominal conditions at an early stage. Earlier studies have suggested that there is a relationship between serum levels of the proteolytic enzyme trypsinogen-2 and pancreatic damage , while more recent work has demonstrated increased urine and serum levels of trypinogen-2 in AP . Based on promising results with a quantitative test for trypsinogen-2 in urine, which is markedly increased in patients with AP, we have developed a rapid test strip for detection of trypsinogen-2 in urine and evaluated its utility in the diagnosis of AP.