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Pharmacotherapeutics of the Thyroid Gland pp 171–188Cite as

Iodine: Metabolism and Pharmacology

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 128))

Abstract

The synthesis of normal quantities of thyroid hormones containing iodine in the molecules depends on the availability of adequate quantities of exogenous iodine. Iodine participates not only in an essential substrate for thyroid hormone biosynthesis, but also in many pharmacological actions. Therefore, the effect of iodine on the thyroid is a combination of the effects of pharmacological action and the effects of iodine as a substrate for thyroid hormone.

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References

  • Becks GP, Eggo MC, Burrow GN (1988) Organic iodine inhibits deoxyribonucleic acid synthesis and growth in FRTL-5 thyroid cells. Endocrinology 123: 545–551

    Google Scholar 

  • Becks GP, Eggo MC, Burrow GN (1987) Regulation of differentiated thyroid function by iodide: preferential inhibitory effect of excess iodide on thyroid hormone secretion in sheep thyroid cell cultures. Endocrinology 120: 2569–2575

    Article  PubMed  CAS  Google Scholar 

  • Beere HM, Soden J, Tomlinson S, Bidey SP (1991) Insulin-like growth factor-I production and action in porcine thyroid follicular cells in monolayer: regulation by transforming growth factor-ß. J Endocrinol 130: 3–9

    Article  PubMed  CAS  Google Scholar 

  • Braverman LE, Ingbar SH (1963) Changes in thyroidal function during adaptation to large doses of iodide. J Clin Invest 42: 1216–1231

    Article  PubMed  CAS  Google Scholar 

  • Bray GA (1968) Increased sensitivity of the thyroid in iodine-depleted rats to the goitrogenic effect of thyrotropin. J Clin Invest 47: 1640–1647

    Article  PubMed  CAS  Google Scholar 

  • Burke G (1970) Effects of iodide on thyroid stimulation. J Clin Endocrinol 30: 76–84

    Article  CAS  Google Scholar 

  • Cabanillas AM, Masini-Repiso AM, Costamagna ME (1994) Thyroid iodide transport is reduced by administration of monoamine oxidase A inhibitors to rats. J End-ocrinol 143: 303–308

    Article  CAS  Google Scholar 

  • Carrasco N (1993) Iodine transport in the thyroid gland. Biochem Biophys Acta 1154: 65–82

    PubMed  CAS  Google Scholar 

  • Chapman A (1941) The relation of the thyroid and pituitary glands to iodine metabolism. J Endocrinol 29: 680–685

    Article  CAS  Google Scholar 

  • Chazenbalk GD, Valsecchi RM, Krawiec L, Burton G, Juvenal GJ, Monteagudo E, Chester HA, Pisalev MA (1988) Thyroid autoregulation: inhibitory effects of iodinated derivatives of arachidonic acid on iodine metabolism. Prostaglandins 36: 163

    Article  PubMed  CAS  Google Scholar 

  • Chazenbalk GD, Pisarev MA, Krawiec L, Juvenal GJ, Burton G, Vulsecchi RM (1984) In vitro inhibitory effects of an iodinated derivative of arachidonic acid on calf thyroid. Acta Physiol Pharmacol Latinoam 34: 367

    PubMed  CAS  Google Scholar 

  • Chow CC, Phillips DIW, Lazarus JH, Parkes AB (1991) Effect of low dose iodide supplementation on thyroid function in potentially susceptible subjects: are dietary iodide levels in Britain acceptable? Clin Endocrinol 34: 413–416

    Article  CAS  Google Scholar 

  • Corvilain B, Van Sande J, Laurent E, Dumont JE (1991) The H202-generating system modulates protein iodination and the activity of the pentose phosphate pathway in dog thyroid. Endocrinology 128: 779–785

    Article  PubMed  CAS  Google Scholar 

  • Corvilain B, Van Sande J, Dumont JE (1988) Inhibition by iodide of iodide binding to proteins: the “Wolff-Chaikoff” effect is caused by inhibition of H2O2 generation. Biochem Biophys Res Commun 154: 1287–1292

    Article  PubMed  CAS  Google Scholar 

  • Cowin AJ, Bidey SP (1994) Transforming growth factor-/31 synthesis in human thyroid follicular cells: differential effects of iodide and plasminogen on the production of latent and active peptide forms. J Endocrinol 141: 183–190

    Article  PubMed  CAS  Google Scholar 

  • Cowin AJ, Davis JRE, Bidey SP (1992) Transforming growth factor-/31 production in porcine thyroid follicular cells: regulation by intrathyroidal organic iodine. J Mol Endocrinol 9: 197–205

    Article  Google Scholar 

  • Dai G, Levy O, Carrasco N (1996) Cloning and characterization of the thyroid iodide transporter. Nature 379: 458–460

    Article  PubMed  CAS  Google Scholar 

  • Dugrillion A, Bechtner G, Uedelhoven WM, Weber PC, Gärtner R (1990) Evidence that an iodolactone mediates the inhibitory effect of iodide on thyroid cell proliferation but not on adenosine 3’, 5’-monophosphate formation. Endocrinology 127: 337–343

    Article  Google Scholar 

  • Dumont JE, Vassart G (1995) Thyroid regulation. In: DeGroot LJ (ed) Endocrinology, 3rd edn. Saunders, Philadelphia, p 543

    Google Scholar 

  • Filetti S, Rapoport B (1984) Autoregulation by iodine of thyroid protein synthesis: influence of iodine on amino acid transport in cultured thyroid cells. Endocrinology 114: 1379–1385

    Article  PubMed  CAS  Google Scholar 

  • Galton VA, Pitt-Rivers R (1959) The effect of excessive iodine on the thyroid of the rat. Endocrinology 64: 835–839

    Article  PubMed  CAS  Google Scholar 

  • Gardner DF, Centor RM, Utiger RD (1988) Effects of low dose oral iodide supplementation on thyroid function in normal men. Clin Endocrinol 28: 283–288

    Article  CAS  Google Scholar 

  • Gerard C, Rigot V, Penel C (1994) Chloride channel blockers inhibit the Na’/Isymporter in thyroid follicles in culture. Biochem Biophys Res Comm 204: 1265–1271

    Article  Google Scholar 

  • Grollman E, Smolar A, Ommaya A, Tombaccini D, Santisteban P (1986) Iodine suppression of iodine uptake in FRTL-5 thyroid cells. Endocrinology 118: 2477–2482

    Google Scholar 

  • Halmi NS (1961) Thyroidal iodide transport. Vitam Horm 19: 133–163

    Article  CAS  Google Scholar 

  • Halmi NS, Spirtos BN (1955) Analysis of the modifying effect of dietary iodine levels on the thyroidal response of hypophysectomized rats to thyrotropin. Endocrinology 56: 157–160

    Article  PubMed  CAS  Google Scholar 

  • Heldin NE, Karlsson FA, Westermark B (1987) A growth stimulatory effect of iodide is suggested by its effect on c-myc messenger ribonucleic acid levels, [3H]thymidine incorporation, and mitotic activity of porcine follicular cells in suspension culture. Endocrinology 121: 757–764

    Article  PubMed  CAS  Google Scholar 

  • Ikeda H, Nagataki S (1976) Augmentation of thyrotropin responses to thyrotropin- releasing hormone following inorganic iodide. Endocrinol Jpn 23: 431–436

    Article  PubMed  CAS  Google Scholar 

  • Isozaki O, Tsushima T, Emoto N, Saji M, Tsuchiya Y, Demura H, Sato Y, Shizume K, Kimura S, Kohn LN (1991) Methimazole regulation of thyroglobulin biosynthesis and gene transcription in rat FRTL-5 thyroid cells. Endocrinology 128: 3113–3121

    Article  PubMed  CAS  Google Scholar 

  • Isozaki O, Tsushima T, Miyakawa M, Emoto N, Demura H, Sato Y, Shizume K, Arai M (1993) Iodine regulation of endothelin-1 gene expression in cultured porcine thyroid cells: possible involvement in autoregulation of the thyroid. Thyroid 3: 239–244

    Article  PubMed  CAS  Google Scholar 

  • Kaminsky SM, Levy O, Salvador C, Dai G, Carrasco N (1994) Na’/I- symport activity is present in membrane vesicles from thyrotropin-deprived non-L-transporting cultured thyroid cells. Proc Natl Acad Sci USA 91: 3789–3793

    Article  PubMed  CAS  Google Scholar 

  • Kasai K, Yamaguchi F, Hosoya T, Ichimura K, Banba N, Emoto T, Hiraiwa M, Hishinuma A, Hattori Y, Shimoda S (1992) Effects of inorganic iodide, epidermal growth factor and phorbol ester on hormone synthesis by porcine thyroid follicles cultured in suspension. Life Sci 51: 1095–1103

    Article  PubMed  CAS  Google Scholar 

  • Many MC, Mestdagh C, Van Den Hove MF, Denef JF (1992) In vitro study of acute toxic effects of high iodide doses in human thyroid follicles. Endocrinology 131: 621–630

    Article  PubMed  CAS  Google Scholar 

  • Morton ME, Chaikoff IL, Rosenfeld S (1944) Inhibiting effect of inorganic iodide on the formation in vitro of thyroxine and diiodotyrosine by surviving thyroid tissue. J Biol Chem 154: 381–387

    CAS  Google Scholar 

  • Nagataki S (1974) Effect of excess quantities of iodide. In: Greer MA, Solomon DH (eds) Handbook of physiology, Sect 7. Endocrinology 3. American Physiological Society, Washington DC, p 329

    Google Scholar 

  • Nagataki S (1993) Autoregulation of thyroid function by iodide. In: Delange F, Dunn JT, Glinoer D (eds) Iodine deficiency in Europe: a continuing concern. Plenum, New York, p 43

    Google Scholar 

  • Nagataki S, Ingbar SH (1964) Relation between qualitative and quantitative alterations in thyroid hormone synthesis induced by varying doses of iodide. Endocrinology 74: 731–736

    Article  PubMed  CAS  Google Scholar 

  • Nagataki S, Shizume K, Nakao K (1970a) Alternations in intrathyroidal iodine metabolism in response to chronic iodine administration. Endocrinology 87: 1218–1227

    Article  Google Scholar 

  • Nagataki S, Shizume K, Nakao K (1970b) Effect of iodide on thyroidal iodine turnover in hyperthyroid subjects. J Clin Endocrinol Metab 30: 469–478

    Article  PubMed  CAS  Google Scholar 

  • Nagataki S, Shizume K, Nakao K (1967) Thyroid function in chronic excess iodide ingestion: comparison of thyroidal absolute iodine uptake and degradation of thyroxine in euthyroid Japanese subjects. J Clin Endocrinol Metab 27: 638–647

    Article  PubMed  CAS  Google Scholar 

  • Namba H, Yamashita S, Kimura H, Yokoyama N, Usa T, Otsuru A, Izumi M, Nagataki S (1993) Evidence of thyroid volume increase in normal subjects receiving excess iodide. J Clin Endocrinol Metab 76: 605–608

    Article  PubMed  CAS  Google Scholar 

  • Nasu M, Sugawara M (1994) Exogenous free iodotyrosine inhibits iodide transport through the sequential intracellular events. Eur J Endocrinol 130: 601–607

    Article  PubMed  CAS  Google Scholar 

  • Pang X-P, Park M, Hershman JM (1992) Transforming growth factor-ß blocks protein kinase-A-mediated iodide transport and protein kinase-C-mediated DNA synthesis in FRTL-5 rat thyroid cells. Endocrinology 131: 45–50

    Article  PubMed  CAS  Google Scholar 

  • Penel C, Rognoni JB, Bastiani P (1987) Thyroid autoregulation: impact on thyroid structure and function in rats. Am J Physiol 253: 165–172

    Google Scholar 

  • Pisarev MA (1985) Thyroid autoregulation. J Endocrinol Invest 8: 475–484

    PubMed  CAS  Google Scholar 

  • Pisarev MA, Bocanera LV, Chester HA, Kleiman DL, Juvenal GJ, Pregliasco LB,Krawiec L (1992) Effect of iodoarachidonates on thyroid FRTL-5 cell growth.Horm Metab Res 24: 558–561

    Article  PubMed  CAS  Google Scholar 

  • Price DJ, Sherwin JR (1986) Autoregulation of iodide transport in the rabbit: absence of autoregulation in fetal tissue and comparison of maternal and fetal thyroid iodination products. Endocrinology 119: 2547–2552

    Article  PubMed  CAS  Google Scholar 

  • Raben MS (1949) The paradoxical effects of thiocyanate and of thyrotropin on the organic binding of iodine by the thyroid in the presence of large amounts of iodide. Endocrinology 45: 296–304

    Article  PubMed  CAS  Google Scholar 

  • Rapoport B, Niepomniszcze H, Bigazze M, Hati R, DeGroot LJ (1972) Studies on the pathogenesis of poor thyroglobulin iodination in non-toxic multinodular goiter. J Clin Endocrinol Metab 34: 822–830

    Article  PubMed  CAS  Google Scholar 

  • Rapoport B, West MN, Ingbar SH (1975) Inhibitory effect of dietary iodine on the thyroid adenylate cyclase response to thyrotropin in the hypophysectomized rat. J Clin Invest 56: 516–519

    Article  PubMed  CAS  Google Scholar 

  • Saberi M, Utiger RD (1975) Augmentation of thyrotropin response to thyrotropinreleasing hormone following small decreases in serum thyroid hormone concentrations. J Clin Endocrinol Metab 46: 435–441

    Article  Google Scholar 

  • Saito K, Yamamoto K, Nagayama I, Uemura J, Kuzuya T (1989) Effect of internally loaded iodide, thiocyanate, and perchlorate on sodium-dependent iodide uptake by phospholipid vesicles reconstituted with thyroid plasma membranes: iodide counterflow mediated by the iodide transport carrier. J Biochem 105: 790–793

    PubMed  CAS  Google Scholar 

  • Saji M, Isozaki O, Tsushima T, Arai M, Miyakawa M, Ohba Y, Tsuchiya Y, Sano T, Shizume K (1988) The inhibitory effect of iodide on growth of rat thyroid (FRTL5) cells. Acta Endocrinol (Copenh) 119: 145–151

    CAS  Google Scholar 

  • Saji M, Moriarty J, Ban T, Singer DS, Kohn LD (1992) Major histocompatibility complex class I gene expression in rat thyroid cells is regulated by hormones, methimazole, and iodide as well as interferon. J Clin Endocrinol Metab 75: 871–878

    Article  PubMed  CAS  Google Scholar 

  • Sherwin JR, Prince DJ (1986) Autoregulation of thyroid iodide transport: evidence for the mediation of protein synthesis in iodide-induced suppression of iodide transport. Endocrinology 119: 2553–2559

    Article  PubMed  CAS  Google Scholar 

  • Takasu N, Honda Y, Kawaoi A, Shimizu Y, Yamada T (1985) Effects of iodide on thyroid follicle structure and electrophysiological potentials of culture thyroid cells. Endocrinology 117: 71–76

    Article  PubMed  CAS  Google Scholar 

  • Taton M, Lamy F, Roger PP, Dumont JE (1993) General inhibition by transforming growth factor /31 of thyrotropin and cAMP responses in human thyroid cells in primary culture. Mol Cel Endocrinol 95: 13–21

    Article  CAS  Google Scholar 

  • Taurog A (1970) Thyroid peroxidase and thyroxine biosynthesis. Recent Prog Horm Res 26: 189–247

    PubMed  CAS  Google Scholar 

  • Tramontano D, Veneziani BM, Lombardi A, Villone G, Ingbar SH (1989) Iodine inhibits the proliferation of rat thyroid cells in culture. Endocrinology 125: 984–992

    Article  PubMed  CAS  Google Scholar 

  • Uchimura H, Chiu SC, Kuzuya N, Ikeda H, Ito K, Nagataki S (1980) Effect of iodine enrichment in vitro on the adenylate cyclase-adenosine 3’, 5’ monophosphate system in thyroid glands from normal subjects and patients with Graves’ disease. J Clin Endocrinol Metab 50: 1066–1070

    Article  PubMed  CAS  Google Scholar 

  • Vagenakis AG, Rapoport B, Azizi F, Portnay GI, Braverman LE, Ingbar SH (1974) Hyperresponse to thyrotropin-releasing hormone accompanying small decreases in serum thyroid hormone concentrations. J Clin Invest 54: 913–918

    Article  PubMed  CAS  Google Scholar 

  • Van Sande J, Dumont JE (1973) Effects of thyrotropin, prostaglandin E, and iodide on cyclic 3’, 5’-AMP concentration in dog thyroid slices. Biochim Biophys Acta 313: 320–326

    PubMed  Google Scholar 

  • Van Sande J, Lefort A, Beebe S, Roger P, Parret J, Corbin J, Dumont JE (1989) Pairs of cyclic AMP analogs, that are specifically synergistic for type I and type II cAMP-dependent protein kinase, mimic thyrotropin effects on the function, differentiation expression and mitogenesis of dog thyroid cells. Eur J Biochem 183: 699–708

    Article  PubMed  Google Scholar 

  • Van Sande J, Grenier G, Willems C, Dumont JE (1975) Inhibition by iodide of the activation of the thyroid cyclic 3’, 5’-AMP system. Endocrinology 96: 781–786

    Article  PubMed  Google Scholar 

  • Vilijin F, Carrasco N (1989) Expression of the thyroid sodium/iodine symporter in Xenopus laevis oocytes. J Biol Chem 264: 11901–11903

    Google Scholar 

  • Westermark K, Karlsson FA, Westermark B (1983) Epidermal growth factor modu-lates thyroid growth and function in culture. Endocrinology 112:1680–1686

    Article  PubMed  CAS  Google Scholar 

  • Wolff J, Chaikoff IL (1948) Plasma inorganic iodide as a homeostatic regulator of thyroid function. J Biol Chem 174: 555–564

    Google Scholar 

  • Wolff J, Chaikoff IL, Goldberg RC, Meier JR (1949) The temporary nature of the inhibitory action of excess iodide on organic iodine synthesis in the normal thyroid. Endocrinology 45: 504–513

    Article  PubMed  CAS  Google Scholar 

  • Yamada T, Takasu N (1985) Effects of excess iodide on thyroid hormone synthesis and release. In: Hall R, Kobberling J (eds) Thyroid disorders associated with iodine deficiencies and excess. Raven, New York, p 319

    Google Scholar 

  • Yokoyama N, Tominaga T, Eishima K, Izumi M (1991) Effect of iodide on human thyroid peroxidase in thyroid cells. In: Gordon A, Gross J, Hennemann G (eds) Progress in thyroid research. Balkema, Rotterdam, p 483

    Google Scholar 

  • Young RL, Harvey WC, Mazzaferri EL, Reynolds JC, Hamilton CR Jr. (1975) Thyroid-stimulating hormone levels in idiopathic euthyroid goiter. J Clin Endocrinol Metab 41: 21–26

    Article  PubMed  CAS  Google Scholar 

  • Yuasa R, Eggo MC, Meinkoth J, Dillmann WH, Burrow GN (1992) Iodide induces transforming growth factor beta, ( TGF-ß,) mRNA in sheep thyroid cells. Thyroid 2: 141–145

    Google Scholar 

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Authors
  1. S. Nagataki
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  2. N. Yokoyama
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Editors and Affiliations

  1. Department of Medicine Clinical Sciences Centre Northern General Hospital, The University of Sheffield, Sheffield, S5 7AU, UK

    A. P. Weetman (Professor of Medicine) (Professor of Medicine)

  2. Department of Endocrinology, St. Bartholomew’s Hospital, West Smithfield, London, EC1A 7BE, UK

    A. Grossman

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© 1997 Springer-Verlag Berlin Heidelberg

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Nagataki, S., Yokoyama, N. (1997). Iodine: Metabolism and Pharmacology. In: Weetman, A.P., Grossman, A. (eds) Pharmacotherapeutics of the Thyroid Gland. Handbook of Experimental Pharmacology, vol 128. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60709-7_7

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  • DOI: https://doi.org/10.1007/978-3-642-60709-7_7

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  • Print ISBN: 978-3-642-64519-8

  • Online ISBN: 978-3-642-60709-7

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